Research field (2)：
Pharmacology
, Neuroscience - general
Research keywords (6)：
Development of therapeutics for neurodegerative diseases
, 応用薬理学・医療系薬学
, 神経化学・神経薬理学
, Applied Pharmacology and Medical Pharamacology
, Neurochemistry and Neuropharmacology
, Nitric Oxide
Research theme for competitive and other funds (27)：
2015 - 2018 micro RNA as the master key for protection of oxidative stress
2012 - 2016 A study on mice with hypoglycemia and high cognitive ability
2009 - 2011 A study on CNS oxidative stress-resistant mouse
2005 - 2006 Effect of an alpha-lb adrenoceptor antagonist on methamphetamine-induced neuronal toxicity
2002 - 2003 Rotenone-Induced Parkinsonism
2002 - 新規パーキンソン病治療薬の基礎研究
2000 - 2001 Implications of nitrocathecholamines in Parkinson's disease
2000 - New drugs for Pankinson's disease
1997 - 1998 Research on a novel endogenous catecholamine, 6-nitronorepinephrine
1997 - 1998 Regulation of Monoaminergic Neurons in the Brain through Both Nitiric Oxide and Superoxide Anion
1994 - 1994 血管平滑筋の新しい増殖促進機構:壁内外圧力差
1993 - 1993 血管平滑筋細胞における腫瘍壊死因子によるNO生成酵素誘導の特異性
1993 - 1993 血管における内皮依存性NO生成酵素誘導の機構
1992 - 1992 内皮からの新しいNO遊離調節機構:血管壁内外圧力差
1992 - 1992 アゴニストおよび張力刺激による血管内皮由来弛緩因子の生成増強機構
1991 - 1992 Development of antihypertensive drugs: L-arginine and its derivatives as a precursor of endothelium-derived relaxing factor
1991 - 1991 Lーアルギニンの血圧降下作用機序の解明
1991 - 1991 アゴニストおよび張力刺激による血管内皮由来弛緩因子の生成増強機構
1990 - 1990 血管収縮の内皮細胞依存性脱感作に関与する物質の解析
1989 - 1990 Simultaneous Monitoring of Intracellular Calcium Concentration and Catecholamine Release from Superfused PC 12 Cells and Adrenal Chromaffin Cells Cultured on Microcarrier Beads.
1987 - 1988 Menbrane phospholipase c activation and signal transduction in relation to change of receptor-linkage mechanism
1) Oxidative stress in the brain 2) Innovative drugs for Parkinson's disease
Role of NO in central nervous system
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Papers (211)：
Nobuko Matsumura, Chisato Kinoshita, Wattanaporn Bhadhprasit, Toshio Nakaki, Koji Aoyama. A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis. Journal of pharmacological sciences. 2023. 151. 1. 37-45
Chisato Kinoshita, Kazue Kikuchi-Utsumi, Koji Aoyama, Ryo Suzuki, Yayoi Okamoto, Nobuko Matsumura, Daiki Omata, Kazuo Maruyama, Toshio Nakaki. Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression. Communications biology. 2021. 4. 1. 182-182
Matsumura Nobuko, Kinoshita Chisato, Nakaki Toshio, Aoyama Koji. The development of miR-96-5p gene knock out technique by CRISPR/Cas9 system. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 0. 3-P1-37
Kinoshita Chisato, Matsumura Nobuko, Aoyama Koji, Nakaki Toshio. Increased glutathione via NOVA1 by administration of an inhibitor of the microRNA miR-96-5p. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 0. 1-P1-34
Chisato Kinoshita, Yayoi Okamoto, Koji Aoyama, Toshio Nakaki. MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases. Clocks & sleep. 2020. 2. 3. 282-307
Matsumura Nobuko, Aoyama Koji, Nakaki Toshio. Structure-dependent action of caffeine derivatives on cysteine uptake in mouse hippocampus slice. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 133. 3. S175-S175
Kikuchi-Utsumi Kazue, Matsumura Nobuko, Watabe Masahiko, Nakaki Toshio. Effect of nitric oxide synthase inhibitor on methamphetamine-induced dopaminergic neurotoxicity in rats. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2016. 130. 3. S232-S232
Matsumura Nobuko, Aoyama Koji, Nakaki Toshio. Effects of caffeine metabolites on the ability of cysteine uptake in brain slice. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2016. 130. 3. S193-S193
