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J-GLOBAL ID：200901072288633974   Update date: Sep. 28, 2024

Nagatsu Toshiharu

ナガツ トシハル | Nagatsu Toshiharu
Affiliation and department：
Fujita Health University School of Medicine

About Fujita Health University School of Medicine


Job title： Adviser of School of Medicine
Research field  (1)： Neuroscience - general
Research keywords  (2)： 神経化学 ,  molecular neurobiochemistry
Research theme for competitive and other funds  (44)：
  • 2008 - 2010 Neuroscientific studies on the effect of moxibustion on chronic diseases
  • 2006 - 2007 The relationship between the intracellular stability of tyrosine hydroxylase and the neurodegeneration regulated by α-synuclein
  • 2000 - 2000 単一遺伝子異常による神経細胞死
  • 1998 - 2000 Association of genetic polymorphisms with drug-response and personality in mood disorders
  • 1997 - 2000 Molecular Mechanisms of Neuronal Death and Strategies for Neuroprotection
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Papers (458)：
  • Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu, Fabio A. Zucca, Luigi Zecca, Moussa Youdim, Maximilian Wulf, Peter Riederer, et al. The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson’s disease. Journal of Neural Transmission. 2023
  • Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu. Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase. International Journal of Molecular Sciences. 2022. 23. 8. 4176-4176
  • Johannes M Dijkstra, Toshiharu Nagatsu. Cognitive behavioral therapy (CBT), acceptance and commitment therapy (ACT), and Morita therapy (MT); comparison of three established psychotherapies and possible common neural mechanisms of psychotherapies. Journal of neural transmission (Vienna, Austria : 1996). 2021
  • Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Toshiharu Nagatsu, Kazunao Kondo. Salivary neopterin and related pterins: their comparison to those in plasma and changes in individuals. The Journal of Biochemistry. 2021
  • Akira Nakashima, Hisateru Yamaguchi, Mii Kondo, Takahiro Furumura, Yu Kodani, Yoko S Kaneko, Miho Kawata, Hiroshi Nagasaki, Toshiharu Nagatsu, Akira Ota. NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity. Journal of neural transmission (Vienna, Austria : 1996). 2020
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MISC (354)：
  • Toshiharu Nagatsu, Ikuko Nagatsu. Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects. JOURNAL OF NEURAL TRANSMISSION. 2016. 123. 11. 1255-1278
  • 金子葉子, 中島昭, 長崎弘, 小谷侑, 永津俊治, 太田明. リポポリサッカライドはUV照射によるBV-2細胞のアポトーシスを抑制する. 日本分子生物学会年会プログラム・要旨集(Web). 2014. 37th. WEB ONLY 1P-0704
  • Akira Nakashima, Yoko S. Kaneko, Keiji Mori, Hiroshi Nagasaki, Toshiharu Nagatsu, Akira Ota. Intracellular Stability of Tyrosine Hydroxylase: Phosphorylation and Proteasomal Digestion of the Enzyme. Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 2013. 11-12
  • Y. S. Kaneko, A. Nakashima, K. Mori, H. Nagasaki, Y. Kodani, I. Nagatsu, T. Nagatsu, A. Ota. Regulation of oxidative stress in long-lived lipopolysaccharide-activated microglia. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 64-64
  • A. Nakashima, Y. S. Kaneko, K. Mori, H. Nagasaki, T. Nagatsu, A. Ota. Phosphorylation and proteasomal digestion of tyrosine hydroxylase. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 117-117
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Books (22)：
  • Molecular genetics of dopa-responsive dystonia
    Advances in Neurology,Parkinson's Disease (Lippincott william & Wilkins, Philadelphia) 1999
  • Tetrahydroisoquinolines and neurodegeneration
    The role of catecholamine quinone species in cellular toxicity (Graham Publishing,Johnson Gty) 1999
  • Neurotrophins and cytokines in Parkinson's disease.
    Advances in Neurology, Parkinson's Disease (Lippincott Williams & Wilkins, Philadelphia) 1999
  • Gene therapy of a rodent model of Parkinson's disease using adeno-associated virus (AAV) vectors.
    Progress in Alzheimer's and Parkinson's Diseases (Plenum Press, New York) 1998
  • Cytokines in Parkinson's disease.
    Progress in Alzheimer's and Parkinson's diseases (Plenum Press, New York) 1998
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Education (4)：
  • - 1960 Nagoya University
  • - 1960 Nagoya University Graduate School, Division of Medicine
  • - 1955 Nagoya University School of Medicine
  • - 1955 Nagoya University Faculty of Medicine
Professional career (1)：
  • (BLANK)
Committee career (5)：
  • 2001 - 国際神経学連合(パーキンソン病と関連疾患研究)(The World Federation of Neurology's Research Committee on Parkinson's Disease and related Disordors) 委員会会員(Committee Member)
  • 1991 - 日本ビタミン学会 理事
  • 1991 - 日本神経科学学会 理事
  • 1990 - 日本神経化学会 理事
  • 1990 - 日本生化学会 会長,会頭
Awards (9)：
  • 1998 - NIH Fogarty Scholar
  • 1995 - 読売東海医学賞
  • 1995 - 紫綬褒章(生化学研究の功積)
  • 1994 - 日本医師会医学賞
  • 1994 - 上原賞
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Association Membership(s) (9)：
国際神経学連合(パーキンソン病と関連疾患研究)(The World Federation of Neurology's Research Committee on Parkinson's Disease and related Disordors) ,  日本分子生物学会 ,  国際神経化学会(ISN) ,  国際脳研究機構(IBRO) ,  英国生化学会 ,  日本ビタミン学会 ,  日本神経科学学会 ,  日本神経化学会 ,  日本生化学会
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