2019 - 2022 Molecular cytological clarification of pathogenesis of male infertility by analyzing genetically modified animals and its clinical application
2013 - 2015 Approach for establishment of spermatogenic cells from Muse cells
2011 - 2012 Induction of spermatogenic cells from human multipotent stem cell by microinjection into the mouse testis
2010 - 2012 Analysis of the functions of the membrane protein basigin during spermatogenesis and in spermagozoa
Papers (35)：
Chizuru Ito, Tohru Mutoh, Kiyotaka Toshimori. Spermatozoa from male mice with infertility due to Odf4 deficiency can fertilize oocytes by in vitro fertilization. Reproductive medicine and biology. 2024. 23. 1. e12605
Chizuru Ito, Tsukasa Makino, Tohru Mutoh, Masahide Kikkawa, Kiyotaka Toshimori. The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape. Scientific Reports. 2023. 13. 1. 2969-2969
Saito T, Terajima M, Taga Y, Hayashi F, Oshima S, Kasamatsu A, Okubo Y, Ito C, Toshimori K, Sunohara M, et al. Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone. Bone. 2021. 154. 116242
Watanabe E, Akamatsu T, Omori M, Kato M, Takeuchi N, Ishiwada N, Nishimura R, Hishiki H, Fujimura L, Ito C, et al. Recombinant thrombomodulin attenuates hyper-inflammation and glycocalyx damage in a murine model of streptococcus pneumoniae-induced sepsis. Cytokine. 2021. 149. 155723
Yu Okitsu, Mamoru Nagano, Takahiro Yamagata, Chizuru Ito, Kiyotaka Toshimori, Hideo Dohra, Wataru Fujii, Keiichiro Yogo. Dlec1 is required for spermatogenesis and male fertility in mice. Scientific Reports. 2020. 10. 1. 18883-18883
Ito C, Akutsu H, Yao R, Yoshida K, Yamatoya K, Mutoh T, Makino M, Aoyama K, Ishikawa H, Kunimoto K, et al. Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice. 2021. 177
Sakai K, Ito C, Ito T, Takada S, Toshimori K, Sekita Y, Kimura T. Ubiquitin specific peptidase 26 (Usp26) regulates spermatogenesis in mice. MBSJ 2018 Program. 2018. 187-187
Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice
(Proceedings of the 126th Annual Meeting of The Japanese Association of Anatomists and the 98th Annual Meeting of The Physiological Society of Japan 2021)
