Rchr
J-GLOBAL ID:200901072639920185   Update date: Mar. 05, 2021

Matozaki Takashi

マトザキ タカシ | Matozaki Takashi
Affiliation and department:
Job title: Professor
Homepage URL  (2): https://www.med.kobe-u.ac.jp/tougou/signal/Home.htmlhttps://www.med.kobe-u.ac.jp/tougou/signal/Home.html
Research field  (5): Immunology ,  Functional biochemistry ,  Pathobiochemistry ,  Internal medicine - General ,  Medical biochemistry
Research keywords  (8): Immunology ,  Cancer ,  Cell adhesion ,  Cell-cell communication signals ,  免疫 ,  がん ,  細胞接着 ,  細胞間シグナル伝達機構
Research theme for competitive and other funds  (57):
  • 2018 - 2021 がん細胞の生存・維持の分子機構の解明
  • 2016 - 2018 Novel regulatory mechanisms of the intestinal immunity via the microvilli of intestinal epithelial cells
  • 2014 - 2017 Molecular basis of the CD47-SIRP alpha signaling system in the regulation of physiological function
  • 2017 - (AMED)貪食細胞-がん細胞相互作用を制御する新たながん免疫療法の開発
  • 2017 - (AMED)多機能幹細胞を用いた自然免疫再構築による新規肝炎/肝癌治療法の開発/CD34+肝細胞由来顆粒球・マクロファージ前駆細胞系の抗腫瘍機構の解明
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Papers (167):
  • Takashi Matozaki, Takenori Kotani, Yoji Murata, Yasuyuki Saito. Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis. Cancer science. 2021. 112. 1. 16-21
  • Taichi Nishimura, Yasuyuki Saito, Ken Washio, Satomi Komori, Datu Respatika, Takenori Kotani, Yoji Murata, Hiroshi Ohnishi, Satoshi Mizobuchi, Takashi Matozaki. SIRPα on CD11c+ cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis. European journal of immunology. 2020. 50. 10. 1560-1570
  • Yoji Murata, Yasuyuki Saito, Takenori Kotani, Takashi Matozaki. Blockade of CD47 or SIRPα: a new cancer immunotherapy. Expert opinion on therapeutic targets. 2020. 24. 10. 945-951
  • Daisuke Hazama, Yizhen Yin, Yoji Murata, Makoto Matsuda, Takeshi Okamoto, Daisuke Tanaka, Naohiro Terasaka, Jinxuan Zhao, Mariko Sakamoto, Yuka Kakuchi, et al. Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy. Cell chemical biology. 2020. 27. 9. 1181-1191
  • Takenori Kotani, Jajar Setiawan, Tasuku Konno, Noriko Ihara, Saki Okamoto, Yasuyuki Saito, Yoji Murata, Tetsuo Noda, Takashi Matozaki. Regulation of colonic epithelial cell homeostasis by mTORC1. Scientific reports. 2020. 10. 1. 13810-13810
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MISC (109):
Patents (5):
  • 動物種鑑別方法及び装置
  • マクロファージ活性化剤並びにその製造方法及びスクリーニング方法
  • Pharmaceuical Composition And Method For Acivating Macrophage Using The Same
  • CD47部分ペプチドと抗SHPS-1モノクロナール抗体
  • CD47 PARTIAL PEPTIDE AND ANTI-SHPS-1 MONOCLONAL ANTIBODY
Lectures and oral presentations  (257):
  • Antibodies to SIRPα/SIRPβ as a potential tool for immunotherapy of bladder cancer
    (14th International Conference on Protein Phosphatase 2020)
  • Blockade of the CD47-SIRPα interaction by SIRPα-binding macrocyclic peptides as a potential cancer immunotherapy
    (14th International Conference on Protein Phosphatase 2020)
  • Roles of Shp2-Ras, Src family kinases, and mTOR signaling in intestinal epithelial homeostasis
    (14th International Conference on Protein Phosphatase 2020)
  • Role of CD47 on the regulation of peripheral T cell survival by dendritic cells
    (14th International Conference on Protein Phosphatase 2020)
  • A novel humanized mouse model for assessing human macrophage-targeted cancer immunotherapy in vivo
    (14th International Conference on Protein Phosphatase 2020)
more...
Education (4):
  • - 1988 Kobe University
  • - 1988 Kobe University
  • - 1981 Kobe University Faculty of Medicine
  • - 1981 Kobe University
Professional career (1):
  • 医学博士 (神戸大学)
Committee career (3):
  • 2019/04 - 現在 Japanese Association For Protein Phosphatase Research 会長
  • 2018/04 - 現在 The Japanese Cancer Association 評議員
  • 2002/04 - 現在 Japan Society for Cell Biology 評議員
Awards (4):
  • 2021/03 - The Ichiro Kanehara Foundation for the Promotion of Medical Science & Medical Care Seitai-no-Kagaku Award Molecular basis of cancer cell survival by the regulation of innate immunity
  • 2019/12 - The Yasuda Medical Foundation 安田医学賞
  • 2019/11 - Hyogo prefecture 兵庫県科学賞
  • 1992 - 日本消化器病学会 日本消化器病学会奨励賞 英文
Association Membership(s) (12):
日本プロテインホスファターゼ研究会 ,  日本神経化学会 ,  Japan Society for Cell Biology ,  The Japanese Biochemical Society ,  日本内科学会 ,  米国生化学・分子生物学会 ,  日本免疫学会 ,  The Japanese Cancer Association ,  日本分子生物学会 ,  米国癌学会 ,  米国細胞生物学会 ,  北米神経科学会
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