Tsuda Leo

ツダレオ | Tsuda Leo

Affiliation and department：
Job title： Section of Physiology, Section chief
Homepage URL (1)： http://www.ncgg.go.jp/camd/department/ama/index.html

Research field (3)： Pathobiochemistry , Neuroscience - general , Molecular biology

Research keywords (17)：細胞増殖 , 転写制御 , シグナル伝達 , 神経機能低下 , 神経分化 , Mouse , Drosophila , drug discovery , deafness , Alzheimer's disease , 遺伝 , 発生 , 感覚器 , genetics , development , sensory organ , aging

Research theme for competitive and other funds (15)：

2018 - 2021 新規モデル系を用いたアルツハイマー病の神経変性の制御機構の解析
2017 - 2020 糖尿病および加齢はなぜ認知症の危険因子なのか?
2015 - 2018 F-box/WD40リピート蛋白質によるクロマチン制御機構
2010 - 2013 G1期抑制因子による感覚細胞の長期生存維持メカニズム解析
2010 - 2013 ケミカルジェネティックスを用いた加齢性感覚器障害の発症メカニズム解明

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Papers (14)：

Yasutoyo Yamasaki, Leo Tsuda, Akemi Suzuki, Katsuhiko Yanagisawa. Induction of ganglioside synthesis in Drosophila brain accelerates assembly of amyloid β protein. Scientific Reports. 2018. 8. 1. 8345
Tsuda L, Lim YM. Alzheimer's Disease Model System Using Drosophila. Advances in experimental medicine and biology. 2018. 1076. 25-40
Leo Tsuda, Yasuhiro Omata, Yasutoyo Yamasaki, Ryunosuke Minami, Young-Mi Lim. Pyroglutamate-amyloid-beta peptide expression in Drosophila leads to caspase-dependent and endoplasmic reticulum stress-related progressive neurodegeneration. HUMAN MOLECULAR GENETICS. 2017. 26. 23. 4642-4656
Oyinkan Sofola-Adesakin, Mobina Khericha, Inge Snoeren, Leo Tsuda, Linda Partridge. pGluA beta increases accumulation of A beta in vivo and exacerbates its toxicity. ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2016. 4. 1. 109
Omata Y, Tharasegaran S, Lim YM, Yamasaki Y, Ishigaki Y, Tatsuno T, Maruyama M, Tsuda L. Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception. Aging. 2016. 8. 3. 427-439

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Patents (6)：

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Books (9)：

An Alzheimer’s disease model system using Drosophila. (Drosophila Models for Human Disease, Chapter 3)
Springer Nature 2018
新規アルツハイマー病モデルマウス -加齢性感覚器障害とアルツハイマー病との関連-
基礎老化学会 2017
G1期抑制因子による感覚細胞の長期生存維持メカニズム解析、ヒトと医学のステージへ拡大する細胞周期.
羊土社 2013
ショウジョウバエを用いた老化研究 (第1編脳内老化のメカニズムと老化制御の基盤的研究、第2章) 脳内老化制御とバイオマーカー: 基礎研究と食品素材-、大澤俊彦、丸山和佳子監修
シーエムシー出版 2011
ショウジョウバエをモデルとした老化・加齢性神経疾患の研究-ケミカルジェネティックスによるアプローチ
基礎老化学会 2008

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Education (3)：

2001 - 2004 Kanazawa University Graduate School of Natural Science and Technology
1989 - 2001 Kanazawa University
1989 - Kanazawa University Faculty of Pharmaceutical Sciences

Professional career (1)：

理学博士 (金沢大学)

Work history (6)：

2016 - 現在 National Center for Geriatrics and Gerontology Laboratory for Animal Models of Aging Laboratory Head
2010 - 2016 National Center for Geriatrics and Gerontology
2005 - 2010 National Institute for Longevity Science (national Center for geriatrics and Gerontology)
2000 - 2005 RIKEN Center for Developmental Biology Researcher
1995 - 2000 University of California Los Angeles Howard Hughes Medical Institute Postdoctoral Researcher

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Association Membership(s) (5)：

米国遺伝学会 , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS , JAPAN SOCIETY FOR DEMENTIA RESEARCH , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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