Ohshima Hayato

2021 - 2024 歯髄治癒過程における神経伝達物質と自然免疫制御による象牙質再生機構の解明

2021 - 2023 外的侵襲後の歯髄治癒過程における象牙芽細胞、歯髄幹細胞、免疫細胞間クロストーク

2020 - 2023 歯の発生過程における上皮間葉相互作用のプロテオミクスによる解明

2020 - 2023 外傷歯における神経伝達シグナルと人為的血流調節による歯髄静的幹細胞賦活化の試み

2021 - 2022 Cross-talk among odontoblasts, dental pulp stem cells, and immune cells after exogenous injuries

2020 - 2022 Clarification of the origin and maintenance mechanisms of junctional epithelium and identification of its stem cells using allogenic tooth germ transplantation

2019 - 2022 The clarification of the pulp generation mechanism to improve the odontoblast differentiation by the transporter of ascorbic acid.

2019 - 2022 Elucidation of relationship between lingual nerve three-dimensional corse and muscle gap by anatomical head CT.

2018 - 2021 Elucidation of crosstalk between macrophage and regenerative nerve in the process of dental pulp healing

2017 - 2020 Clarification of the homeostatic mechanism and activation of dental pulp progenitor/quiescent stem cells using proteomic approach

2017 - 2020 An investigation of factors that promote dental pulp regeneration and stem cell differentiation in a rat model of coronal pulp regeneration

2017 - 2020 Mechanisms maintaining quiescent stem cells by Shh signaling in the apical bud of incisors and developing molars in mice

2017 - 2020 Elucidation of mechanisms maintaining the homeostasis of quiescent periodontal stem cells demonstrated by tooth germ transplantation

2016 - 2020 Application of novel DDS strategies for induction and regeneration of periodontal tissues

2015 - 2018 Elucidation of the mechanism of dentin bridge formation after MTA direct pulp to the infected dental pulp and the relevance of OPN

2014 - 2018 Microbiota profiling of infected root canals using metagenomic analysis

2014 - 2018 Effects of root resection and antibacterial drugs on the pulpal and periodontal tissue healing following tooth replantation

2014 - 2017 Regeneration of rat molar pulp tissue by the implantation of stem cells from incisor pulp: development of a rat model of autologous pulp tissue engineering

2014 - 2017 Elucidation of construction mechanism of extracellular environment around tooth germs via proteoglycan

2014 - 2017 Paradigm shift of strategies for the control of oral biofilm and a novel antibiofilm chemotherapy targeting exopolysaccharide synthesis.

2013 - 2017 The tooth-format cellular differentiating regulation from iPSCs

2013 - 2016 Subpopulation of dental pulp stem/progenitor cells: Their implication in the differentiation capacity, origin, and microenvironment

2013 - 2016 The localization of putative dental pulp stem cells and the mechanisms regulating their maintenance demonstrated by the prenatal BrdU-labeling method

2013 - 2016 Multifaceted approach to the analyses of dental plaque biofilm targeting dental caries-associated bacteria, and its application to dental caries prevention

2013 - 2015 Novel roles of antimicrobials in the process of pulpal regeneration: its relationship with dendritic cells and dental pulp stem cells

2012 - 2015 Elucidation of new function of glycogen - The possibility as accelerating agent for odontogenesis and osteogenesis

2011 - 2015 Elucidation of the role of dental pulp stem cells and Wnt signaling during pulpal formation demonstrated by tooth germ transplantation

2011 - 2014 Dental pulp regeneration by stem cell transplantation: development of scaffolds and establishment of an animal experimental model

2011 - 2013 Imaging of the microvascular distribution in the mandibular bone marrow using Dual Energy Computed Tomography Imaging; a trial run

2011 - 2013 Diversified approaches for the control of mature oral biofilms targeting to the matrices

2010 - 2012 Interaction between dental pulp stem cells and bone-marrow-derived cells during pulpal regeneration and its clinical implication

2009 - 2011 The mechanism of signal transduction of perlecan in the tooth enamel organ morphogenesis

2008 - 2010 Pathogenic mechanisms in apical periodontitis : innate immunity, acquired immunity and dendritic cell maturation

2008 - 2010 Establishment of the method to induce periodontal tissue cells for the allogenic tooth transplantation in clinical dentistry

2008 - 2009 外傷歯の歯髄再生療法の基盤となる歯髄細胞の分化誘導法の確立

2007 - 2009 Elucidation of the localization and differentiation capacity of dental pulp stem cells

2007 - 2008 Cell dynamics in transition stage from crown to tooth root formation and effects of growth factors in development of Hertwig epithelial root sheath

2006 - 2007 Elucidation of the capacity of dental pulp differentiation as demonstrated by autogenic and allogenic tooth transplantation

2005 - 2007 Repair of dental pulps-Pathohistological evaluation of LSTR 3Mix-MP SavePulp therapy-

2005 - 2007 Immune defense mechanisms of the dentin/pulp complex: Immunohistochemical analysis on the heterogeneity and kinetics of dendritic cells

2004 - 2006 Research on Dental Pulp Stem Cells and Pulpal Healing Process

2004 - 2006 Regeneration of tooth germ using dental epithelial stem cells and dental papilla mesenchymal stem cells in rodent incisors

2003 - 2004 Localization and chronological changes of the adult stem cells in the pulpal regeneration process after tooth replantation and transplantation

2002 - 2004 Pathogenic mechanisms of apical periodontal diseases : Kinetics of dendritic cells and immure functional molecules

2002 - 2003 Possible role of immunocompetent cells and the expression of Hsp25 in the process of pulpal regeneration

2001 - 2002 Possible Roles of Msx2 in Ameloblast differentiation

2001 - 2002 The study on the role of heat shock protein (Hsp) 25 during dental and periodontal regeneration after tooth replantation

2000 - 2002 An attempt to promote formation of neural network on dental implants

2000 - 2001 A STUDY OF DEVELOPMENT/REGENERATION PROCESSES OF THE PERIODONTAL NERVES, WITH SPECIAL REFERENCE TO THE ROLE OF NEUROTROPHINS/NEUROTROPHIN RECEPTORS.

2000 - 2001 Study on the role of heat shock protein 27 in the process of development and regeneration of dental pulp

2000 - 2000 歯胚発生研究のための培養技術の向上を目的としたワークショップ開催

1998 - 1999 Epithelial-mesenchymal interaction during tooth morphogenesis

1998 - 1998 グリア系フィラメントの新たな役割-歯根膜における存在意義-

1996 - 1997 Immunocytochemical and Neurobiological study on Periodontal Nerve Fibers : A Developmental Approach and Experimental Model

1996 - 1996 ヒト歯髄における抗原提示細胞の役割に関する免疫組織化学的研究

1996 - 1996 神経栄養因子の歯周組織での存在意義 非神経要素が神経成長因子受容体をもつ

1995 - 1996 Immunohistochemical and Enzyme-histochemical studies on the cellular networks of antigen-presenting cells in the dental and periodontal tissues.

1995 - 1995 歯髄の免疫防御機構に関する免疫組織化学的研究:大食細胞と樹状細胞の異同について

1994 - 1994 歯髄の免疫防御機構に関する免疫組織化学的研究:特に抗原提示細胞について

1993 - 1994 Periodontal Ligament as a sensory apparaus : A morphological approach to functional property of periodontal nerve terminals

1993 - 1993 新しい乳歯齲蝕・感染根管治療法の確立-病巣無菌化療法-

1992 - 1993 Histochemical and Immunohistochemical Studies on the Mechanisms of Calcium Regulation by Dental and Periodontal Hard Tissue-Forming Cells (1993)