Rchr
J-GLOBAL ID：200901074135504892   Update date: Feb. 01, 2024

KINASHI TATSUO

キナシ タツオ | KINASHI TATSUO
Affiliation and department：
Kansai Medical University

About Kansai Medical University


Job title： Professor
Homepage URL  (1)： http://www3.kmu.ac.jp/molgent/index.html
Research field  (2)： Molecular biology ,  Immunology
Research theme for competitive and other funds  (37)：
  • 2022 - 2025 インテグリンによる細胞相互作用の可塑性と堅牢性の生成メカニズムと生体機能の解明
  • 2017 - 2019 Development of lymphocyte trafficking regulation using single-molecule measurement
  • 2017 - 2019 一分子計測によるリンパ球動態制御法の開発
  • 2015 - 2018 Analysis of spatio-temporal information processing in immune cells
  • 2013 - 2016 Coordinated regulation of cell adhesion and growth through Rap1 signaling and mammalian Hippo pathway.
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Papers (74)：
  • Yoshihiro Ueda, Koichiro Higasa, Yuji Kamioka, Naoyuki Kondo, Shunsuke Horitani, Yoshiki Ikeda, Wolfgang Bergmeier, Yoshinori Fukui, Tatsuo Kinashi. Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1. iScience. 2023. 26. 8. 107292-107292
  • Shunsuke Horitani, Yoshihiro Ueda, Yuji Kamioka, Naoyuki Kondo, Yoshiki Ikeda, Makoto Naganuma, Tatsuo Kinashi. The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes. Frontiers in Immunology. 2023. 14
  • Takataro Fukuhara, Yoshihiro Ueda, Sung-Il Lee, Tokifumi Odaka, Shinsuke Nakajima, Jun-Ichi Fujisawa, Kazu Okuma, Makoto Naganuma, Kazuichi Okazaki, Naoyuki Kondo, et al. Thymocyte Development of Humanized Mice Is Promoted by Interactions with Human-Derived Antigen Presenting Cells upon Immunization. International Journal of Molecular Sciences. 2023. 24. 14. 11705-11705
  • Yuji Kamioka, Yoshihiro Ueda, Naoyuki Kondo, Keizo Tokuhiro, Yoshiki Ikeda, Wolfgang Bergmeier, Tatsuo Kinashi. Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow. Cell Reports. 2023. 42. 6. 112580-112580
  • Naoyuki Kondo, Yoshihiro Ueda, Tatsuo Kinashi. LFA1 Activation: Insights from a Single-Molecule Approach. Cells. 2022. 11. 11. 1751-1751
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MISC (39)：
  • UEDA Yoshihiro, HIGASA Koichiro, KAMIOKA Yuji, KONDO Naoyuki, KINASHI Tatsuo. Rap1 facilitates T cell polarity via spatial regulation of MLC and ARAP1. 日本免疫学会総会・学術集会記録(CD-ROM). 2021. 50
  • KONDO Naoyuki, UEDA Yoshihiro, KINASHI Tatsuo. Kindlin-3 breaks of integrin LFA-1 inhibitory clasp to promote positive feedback activation of LFA-1 by talin1 and Rap1. 日本免疫学会総会・学術集会記録(CD-ROM). 2021. 50
  • 日笠 幸一郎, 植田 祥啓, 玉田 篤史, 上岡 裕治, 近藤 直幸, 福田 尚代, 徳弘 圭造, 六車 恵子, 木梨 達雄. 人工知能を活用した画像認識ニューラルネットワーク基盤の開発. 関西医科大学雑誌. 2020. 71. 33-34
  • 池田幸樹, 木梨達雄. インテグリン創薬から考える一回膜貫通型タンパク質における創薬ストラテジー. SAR News. 2020. 39. 17-23
  • 木梨 達雄. 【ジーンハンティングによる炎症・免疫研究の発展】IL-4およびIL-5の遺伝子クローニング. 炎症と免疫. 2020. 28. 3. 175-180
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Lectures and oral presentations  (27)：
  • 白血球インテグリン接着のメカニズムと炎症性腸疾患への応用
    (第56回日本消化器免疫学会総会 2019)
  • Roles of Rap1 signaling in immunodeficiency and autoimmunity.
    (The 9th Asian Congress of Pediatric Infectious Diseases (ACPID) 2018)
  • Rap1 signaling to NDR1 kinase regulate immune synapse formation and cell polarity.
    (The 9th Xiamen Winter Symposium, The Hippo Signaling Pathway in Development and Disease 2018)
  • Roles of Rap1 signaling in immune synapse formation and self-tolerance
    (The 6th Xiamen Winter Symposium 2015)
  • Regulation of Lymphocyte “Stop and Go” via LFA-1 and ICAM-1: Lymphocyte Trafficking Analysis using Live Imaging Techniques
    (第51回日本生物物理学会年会 2013)
ｍore...
Education (3)：
  • 1986 - 1988 京都大学 大学院(博士課程) 医学研究科
  • 1986 - 1988 Kyoto University
  • 1978 - 1984 Yamaguchi University School of Medicine Faculty of Medicine
Committee career (2)：
  • Japanee Society for Immunology
  • 日本免疫学会 評議員
Awards (1)：
  • 2005/12 - 日本免疫学 第8回日本免疫学会賞
Association Membership(s) (2)：
The molecular Biology Society of Japan ,  Japanee Society for Immunology
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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