Research theme for competitive and other funds (19)：
2017 - 2019 Drug discovery and research for regulation of chronic inflammation caused by microglial activation
2015 - 2018 Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange
2014 - 2018 Establishment of research foundation on "objective pain assessment" using animal models suffering from neuropathic pain
2013 - 2018 Synaptic regulation by intracerebral microglia and chronic pain
2011 - 2016 The role of glial cells in neuropathic pain
2010 - 2016 Comprehensive Brain Science Network
2011 - 2014 Study on the development of molecules for depressing neuropathic pain based on tertiary structure of human P2X4 receptor
2006 - 2010 Research for the mechanism of the expression of neuropathic pain
2003 - 2007 細胞外ATPを介したアストログリア-ニューロン相互調節機構の解明
2006 - 2006 ミクログリアを介する神経因性疼痛発症メカニズムの総合理解
2003 - 2005 The role of neuron-glia interaction in neuropathic pain
1999 - 2002 Neuronal and behavioral research on the function of ATP receptors in the signal trasnduction of pain.
1996 - 1998 A neuropharmacological Research for the Function of ATP Receptors in the Nociception
1997 - 1997 ATP受容体の生理機能と分子機構に関する総合的基礎研究
1995 - 1996 Chromaffin cells as a neuron model
1994 - 1995 Regulation of Exocytosis
1984 - 1984 クローン神経細胞を用いたレセプターアッセイによる抗うつ剤作用機序の検討
1983 - 1983 ラット胎仔中枢神経系の発達に及ぼすエチルアルコール母体投与の影響
グリア-ニューロン相互作用におけるATP受容体の生理機能、薬理作用の解明。
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Papers (244)：
Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, et al. Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. Scientific reports. 2023. 13. 1. 11177-11177
Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Kei-Ichiro Iida, Ken-Ichi Kawaguchi, Yoshihiro Matsumoto, et al. Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. Research square. 2023
Kazuhide Inoue. The Role of ATP Receptors in Pain Signaling. Neurochemical Research. 2022. 47. 9. 2454-2468
Keita Kohno, Ryoji Shirasaka, Kohei Yoshihara, Satsuki Mikuriya, Kaori Tanaka, Keiko Takanami, Kazuhide Inoue, Hirotaka Sakamoto, Yasuyuki Ohkawa, Takahiro Masuda, et al. A spinal microglia population involved in remitting and relapsing neuropathic pain. Science (New York, N.Y.). 2022. 376. 6588. 86-90
Hidetoshi Tozaki-Saitoh, Hiroshi Takeda, Kazuhide Inoue. The Role of Microglial Purinergic Receptors in Pain Signaling. Molecules. 2022. 27. 6
Kazuhide Inoue. Overview for the study of P2 receptors: From P2 receptor history to neuropathic pain studies. Journal of Pharmacological Sciences. 2022. 149. 3. 73-80
Kazuhide Inoue. Nociceptive signaling of P2X receptors in chronic pain states. Purinergic Signalling. 2021. 17. 1. 41-47
Kazuhide Inoue. Role of the P2X4 receptor in neuropathic pain. Current Opinion in Pharmacology. 2019. 47. 33-39
Kazuhide Inoue. A state-of-the-art perspective on microgliopathic pain. Open Biology. 2018. 8. 11
H. Saitoh, J. Masuda, R. Kawada, C. Kojima, S. Yoneda, T. Masuda, M. Tsuda, K. Inoue. Transcription factor MAFB mediates activation of spinal microglia relating to neuropathic pain after peripheral nerve injury. JOURNAL OF NEUROCHEMISTRY. 2017. 142. 85-85
