Mizushima Tsunehiro

ミズシマツネヒロ | Mizushima Tsunehiro

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.sci.u-hyogo.ac.jp/edu/kenkyuu/base41.html

Research field (2)： Biophysics , Structural biochemistry

Research keywords (7)：ユビキチン , プロテアソーム , タンパク質分解 , 構造生物学 , タンパク質 , X線結晶構造解析 , X-ray crystallography

Research theme for competitive and other funds (30)：

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Papers (67)：

Kazuya Nishio, Tomoyuki Kawarasaki, Yuki Sugiura, Shunsuke Matsumoto, Ayano Konoshima, Yuki Takano, Mayuko Hayashi, Fumihiko Okumura, Takumi Kamura, Tsunehiro Mizushima, et al. Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress. Science advances. 2023. 9. 15. eadf1956
Keito Hiragi, Akira Nishide, Kenji Takagi, Kazuhiro Iwai, Minsoo Kim, Tsunehiro Mizushima. Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.5. The Journal of Biochemistry. 2023. 173. 4. 317-326
Akira Nishide, Kenji Takagi, Minsoo Kim, Tsunehiro Mizushima. Active site structure of the Shigella flexneri effector OspI. 2022
Nobuo Kanazawa, Hiroaki Hemmi, Noriko Kinjo, Hidenori Ohnishi, Jun Hamazaki, Hiroyuki Mishima, Akira Kinoshita, Tsunehiro Mizushima, Satoru Hamada, Kazuya Hamada, et al. Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency. Nature communications. 2021. 12. 1. 6819-6819
Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W Moore, Tsunehiro Mizushima, Albena T Dinkova-Kostova, Takuma Kasai, Takashi Kamei, et al. Molecular basis for the disruption of Keap1-Nrf2 interaction via Hinge & Latch mechanism. Communications biology. 2021. 4. 1. 576-576

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MISC (16)：

佐伯泰, 水島恒裕. 【構造生命科学で何がわかるのか、何ができるのか最先端のタンパク質解析技術から構造情報の活用事例、創薬展開まで】 (第3章)巨大分子複合体の構造生物学プロテアソームの作動機構とダイナミクス. 実験医学. 2014. 32. 10. 1617-1622
高木賢治, 水島恒裕. プロテアソーム複合体形成シャペロンの構造と作用機構. 生化学. 2013. 85. 9. 789-794
水島恒裕, 西尾和也. 【細胞内のリノベーション機構タンパク質分解系による生体制御ユビキチン、プロテアソーム、オートファジー、調節性プロテアーゼによる恒常性維持・刷新の新機構と、疾患への関与から創薬戦略まで】 (第1章)細胞内タンパク質分解システム構造からみるプロテアソームの機能. 実験医学. 2011. 29. 12. 1875-1881
Sangwoo Kim, Yasushi Saeki, Keisuke Fukunaga, Atsuo Suzuki, Kenji Takagi, Takashi Yamane, Keiji Tanaka, Tsunehiro Mizushima, Koichi Kato. Crystal Structure of Yeast Rpn14, a Chaperone of the 19 S Regulatory Particle of the Proteasome. JOURNAL OF BIOLOGICAL CHEMISTRY. 2010. 285. 20. 15159-15166
T. Mizushima, Y. Yoshoda, T. Kumanomidou, Y. Hasegawa, A. Suzuki, T. Yamane, K. Tanaka. X-ray structure of the Skp1-Fbs1 glycoprotein complex. FEBS JOURNAL. 2008. 275. 184-184

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Professional career (1)：

Work history (7)：

2021/04 - 現在 University of Hyogo Graduate School of Science professor
2011/04 - 2021/03 University of Hyogo Graduate School of Life Science
2008/04 - 2011/03 Nagoya City University Graduate School of Pharmaceutical Sciences
2007/04 - 2008/03 Nagoya University Graduate School of Engineering
2003/04 - 2007/03 Nagoya University Graduate School of Engineering

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Association Membership(s) (3)：

THE JAPANESE BIOCHEMICAL SOCIETY , THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN , PROTEIN SCIENCE SOCIETY OF JAPAN

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