Rchr
J-GLOBAL ID：200901074513877180   Update date: Dec. 10, 2021

Sakaguchi Suehiro

サカグチ スエヒロ | Sakaguchi Suehiro
Affiliation and department：
The University of Tokushima Graduate School of Biomedical Sciences

About The University of Tokushima Graduate School of Biomedical Sciences


Research field  (1)： Virology
Research keywords  (5)： mad cow disease ,  Creutzfeldt-Jakob disease ,  neurodegeneration ,  prion disease ,  prion
Research theme for competitive and other funds  (22)：
  • 2017 - 2019 プリオン蛋白質は耐性ウイルスを誘導しない夢のインフルエンザ薬のターゲットである
  • 2017 - 2019 プリオン以外のプリオン病の病原体の同定とその病原性メカニズムの解明
  • 2015 - 2017 プリオンの増殖と病原性獲得に重要なプリオンの細胞内移動に関与する分子の同定
  • 2015 - 2017 Elucidation of our recent findings on the protective role of prion protein against lethal infection with influenza A viruses is useful for development of a new type of anti-influenza drugs
  • 2014 - 2017 Development of basic technology for therapy of prion diseases based on Sortilin function
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Papers (77)：
  • Hideyuki Hara, Junji Chida, Keiji Uchiyama, Agriani Dini Pasiana, Etsuhisa Takahashi, Hiroshi Kido, Suehiro Sakaguchi. Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells. Scientific Reports. 2021. 11. 1
  • Hara Hideyuki, Chida Junji, Pasiana Dini Agriani, Uchiyama Keiji, Kikuchi Yutaka, Naito Tomoko, Takahashi Yuichi, Yamamura Junji, Kuromatsu Hisashi, Sakaguchi Suehiro. Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire. International Journal of Molecular Sciences. 2021. Vol.22. No.6. 3268-3268
  • Uchiyama Keiji, Hironori Miyata, Yoshitaka Yamaguchi, Morikazu Imamura, Mariya Okazaki, Agriani Dini Pasiana, Chida Junji, Hara Hideyuki, Ryuichiro Atarashi, Hitomi Watanabe, et al. Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106. International Journal of Molecular Sciences. 2020. Vol.21. No.19. 7260-7260
  • Yasushi Kishimoto, Moritoshi Hirono, Ryuichiro Atarashi, Sakaguchi Suehiro, Tohru Yoshioka, Shigeru Katamine, Yutaka Kirino. Impairment of cerebellar long-term depression and GABAergic transmission in prion protein deficient mice ectopically expressing PrPLP/Dpl. Scientific Reports. 2020. Vol.10. No.1. 15900-15900
  • Hara Hideyuki, Sakaguchi Suehiro. N-terminal Regions of Prion Protein: Functions and Roles in Prion Diseases. International Journal of Molecular Sciences. 2020. Vol.21. No.17. E6233-E6233
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MISC (48)：
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Books (4)：
  • Prion Propagation, Its Neurotoxicity, and Protein Trafficking. Prions
    Caister Academic Press 2019
  • シンプル微生物学(編集:小熊恵二,堀田博,若宮伸隆)
    2018
  • Immunological strategies for the prevention and treatment of prion diseases.
    Caister Academic Press 2013
  • 44章スローウイルスとプリオン
    丸善出版 2012
Lectures and oral presentations  (77)：
  • ウイルス感染を用いたプリオン病発症機構の解明
    (第42回日本分子生物学会年会 2019)
  • プリオン蛋白質はインフルエンザ A ウイルス感染による重症化を軽減する
    (第42回日本分子生物学会年会 2019)
  • Influenza virus infection triggers de novo generation of prions in neuronal cells
    (第41回日本分子生物学会年会 2018)
  • Prion protein provides a protection against influenza A virus infection
    (第66回日本ウイルス学会学術集会 2018)
  • Prion protein protects mice from lethal infection with Influenza A virues
    (2017年度生命科学系学会合同年次大会 (ConBio2017) 第 40回日本分子生物学会年会/第90回日本 生化学会大会 2017)
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Education (1)：
  • 1994 - 長崎大学 大学院医学研究科博士課程 修了
Professional career (1)：
  • 博士(医学) (長崎大学)
Committee career (2)：
  • 2006/06/10 - 2016/03/31 中国四国ウイルス研究会 幹事
  • 2013/08 - 2015/07 アジア太平洋プリオン研究会 理事長
Awards (1)：
  • 2013/07/21 - Asian Pacific Prion Symposium 2013 best presentation prize Prions impair post-Golgi trafficking of membrane proteins
Association Membership(s) (2)：
中国四国ウイルス研究会 ,  Asian Pacific Society of Prion Research
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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