Rchr
J-GLOBAL ID：200901074722765062
Update date: Apr. 02, 2024
MASAHIKO KURABAYASHI
クラバヤシ マサヒコ | MASAHIKO KURABAYASHI
Affiliation and department：
Job title：
Professor
Research field (4)：
Respiratory medicine
, Metabolism and endocrinology
, Cardiology
, Molecular biology
Research keywords (2)：
肺線維症上皮間葉転換肺胞マクロファージTGF-beta
, pulmonary fibrosisEpithelial-mesenchyman transitionalveolar macrophageTGF-beta
Research theme for competitive and other funds (66)：
- 2020 - 2023 次世代シークエンス及び電気生理学的手法を駆使した新規遺伝性不整脈の病態解明
- 2020 - 2023 非典型的肺動脈性肺高血圧症における脂肪酸代謝関連因子を用いた治療反応性の検討
- 2018 - 2023 心臓交感神経イメージング法を用いた右心不全に対する治療効果判定および予後評価
- 2020 - 2023 Regulatory mechanisms of fatty acids synthesis and breadown in pressure-overloaded heart
- 2019 - 2022 Cardiac energetics analysis using myocardial mitochondrial/cytoplasmic ATP visualization mice
- 2017 - 2020 Clarification of molecular mechanisms and establishment of appropriate therapies for atypical inherited arrhythmia syndromes
- 2016 - 2019 Temporal spatial analysis and physiological significance of ATP variability in myocardial infarction by ATP-visualized mice
- 2016 - 2019 Regulation of vascular smooth muscle cell differentiation by fatty acid composition
- 2015 - 2018 Analysis for alteration of fatty acid fraction in COPD and idiopathic pulmonary fibrosis
- 2015 - 2018 The role of PIAS1/SUMO1 on pulmonary hypertension
- 2016 - 2018 Mechanism of pulmonary fibrosis induced by deranged fatty acid composition
- 2014 - 2017 A energy shift from fatty acid to glucose is detrimental to pressure-overloaded heart
- 2014 - 2017 An examination of mutation-specific precipitation factors for ventricular tachyarrhythmias in concealed inherited arrhythmia syndromes
- 2014 - 2017 Study on Machine Learning of Health Big Data Based on Cloud Computing
- 2013 - 2016 Pathophysiological significance of fatty acid composition and catalytic enzyme in pulmonary diseases.
- 2013 - 2016 Cell Type-specific Role of TGFb Signaling in Cardiac Remodeling and Myocardial Energy Metabolism
- 2012 - 2015 The role of Notch1-TGFbeta-PIAS1 on pulmonary hypertension
- 2012 - 2015 Molecular mechanisms of the association between .t2DM and Tskotudo
- 2011 - 2013 Genetic background of ventricular tachyarrhythmias associated with acute myocardial ischemia
- 2011 - 2013 駆出率保持性心不全発症をもたらす心血管系因子の解明と治療法への応用
- 2011 - 2013 Exploration of the optimal biomarkers reflecting each stage of atherosclerotic progression in patients with diabetes mellitus
- 2011 - 2013 Cluster Analysis of Characteristics in the Nature of Personal Health with Healthcare-Data-Mining
- 2012 - 2012 脳エネルギー代謝と行動の制御における毛細血管内皮細胞PPARガンマの役割の解明
- 2010 - 2012 Role of interstitial sodium accumulation on inflammatory cytokines and lymphcapillary reconstruction in salt-sensitive hypertension.
- 2008 - 2010 Investigation of molecular mechanism in the development of chronic obstructive pulmonary disease using klotho mutant mice.
- 2008 - 2010 NOTCH-FABP PATHWAY REGULATES TRANS-ENDOTHELIAL FATTY ACID TRANSPORT IN HEART
- 2008 - 2010 Study on Development of Support System for Healthcare Against Metabolic-Syndrome
- 2008 - 2010 Molecular mechanism of vascular calcification in chronic kidney disease
- 2007 - 2008 Clarification of molecular mechanism regulating differentiation of peripheral blood mononuclear cell into vascular smooth muscle cell and development of new strategy for clinical application
- 2007 - 2007 結合組織増殖因子による心臓線維化・拡張不全発症機序の解明と診断法、治療法の開発
- 2006 - 2007 Investigation of molecular mechanism in the development of pulmonary emphysema and susceptibility to cigarette smoke-induced lung injury using transgenic animal models
- 2006 - 2007 Clarification of vascular smooth muscle cell differentiation by Notch signaling
- 2006 - 2007 Mechanisms of cardiac dysfunction in metabolic syndrome
- 2006 - 2007 Molecular Mechanism of Vascular Calcification
- 2005 - 2006 Role of Angiotension and CD36 Expression in Multiple Risk Factors for Atherosclerosis
- 2005 - 2006 Establishment of novel therapeutic strategy for heart failure by modulating the function of cardiac contractile and relaxation proteins
- 2005 - 2006 動脈硬化におけるNotch-HERP経路の役割の解明と新規治療法の開発
- 2004 - 2005 Investigation of molecular mechanism in the development of chronic obstructive pulmonary disease (COPD) and susceptibility to cigarette smoke-induced lung injury using transgenic animal models.
- 2004 - 2005 Mechanisms of leptin receptor isoforms expression in heart diseases
- 2004 - 2005 Molecular Mechanisms of Vasa Vasorum Angiogenesis and Dysregulation of Vascular Smooth Muscle Cell Differentiation
- 2003 - 2004 血管内皮細胞におけるTNFα関連アポトーシス誘導因子TRALの機能の解明
- 2003 - 2004 Analysis of Inducers of Transformation From Monocytes to Macrophages and Their Application for vascular Protection Therapy
- 2003 - 2004 Development of novel therapeutic strategy for heart failure by improving Ca2+ transport function of sarcoplasmic reticulum
- 2002 - 2003 Hereditary Abnormalities of Multiple Risk Factors for Atherosclerosis ; Role of Endothelial Dysfunction and Aortic CD36 Expression in Diabetic Hyperlipidemic Rats
- 2002 - 2003 Regulation of the tumor necrosis factor-α promoter in the development of heart failure
- 2002 - 2003 Investigation of molecular mechanism in the development of chronic obstructive pulmonary disease (COPD) using transgenic animal models.
- 2002 - 2003 Functional Analysis of p53-Regulatory Protein CARP in Atherosclerosis
- 2001 - 2003 転写因子レベルでの血管狭窄病変の機序解明と遺伝子導入によるその治療戦略
- 2001 - 2002 マクロファージにおけるPPARγを介する動脈硬化関連遺伝子の発現抑制機構の解明
- 2001 - 2002 Development of novel heart failure therapy by using gene transfer into cardiac myocytes
- 2001 - 2002 Investigation of molecular mechanism in the development of lung and pulmonary emphysema in the aging mouse model "klotho" .
- 2000 - 2001 SUPPRESSION OF TUMOR GROWTH BY ANTIANGIOGENIC AGENT AND INDUCTION TO TUMOR DORMANCY IN BREAST CANCER
- 1999 - 2001 The role of Klotho in allograft vascular disease
- 2000 - 2000 血管壁細胞における代血管特異的因子CARPの機能解析
- 1999 - 2000 Transcriptional regulation of the SERCA2 gene during the development of heart failure
- 1999 - 2000 Klotho gene product may have a role to regulate VEGF and p21 and tightly linked to the endothelial function to release NO
- 1999 - 2000 Transcriptional Regulation of the cardiovaocular genes in respone to stress
- 1999 - 1999 成体における血管前駆細胞の固定と血管病態での役割の検討
- 1998 - 1999 Klotho欠損マウスにおける心筋細胞の分化異常に関する研究
- 1998 - 1999 転写因子による血管新生とその抑制の分子機構の解明
- 1997 - 1998 Molecular Mechanisms of Genetic Response of Myocardial Cells to Cytotoxic Stress
- 1997 - 1998 Physiological function of ageing suppression gene klotho and its role in development of adult disease
- 1997 - 1998 Molecular mechanisms of vascular aging : analysis of a newly developed aging mouse
- 1997 - 1997 血管平滑筋細胞における転写因子Idの機能と発現調節機序
- 1996 - 1997 Development of Strategy of Molecular Cloning of Cardiac-Specific-Gene by use of Adriamycin
- 1987 - 1989 Molecular analysis of the pathophysiology of heart disease
Show all
Papers (470)：
-
Ryo Kawakami, Hiroki Matsui, Miki Matsui, Tatsuya Iso, Tomoyuki Yokoyama, Hideki Ishii, Masahiko Kurabayashi. Empagliflozin induces the transcriptional program for nutrient homeostasis in skeletal muscle in normal mice. Scientific reports. 2023. 13. 1. 18025-18025
-
杉浦 有香, 松井 弘樹, 須永 浩章, 磯 達也, 松坂 賢, 島野 仁, 倉林 正彦, 石井 秀樹, 横山 知行. アセトアミノフェン誘導性急性腎障害におけるElovl6の病態生理的意義の解明. The Kitakanto Medical Journal. 2023. 73. 3. 244-244
-
横町 羽南, 松井 弘樹, 須永 浩章, 忠木 沙耶香, 古川 希, 川上 亮, 磯 達也, 小板橋 紀通, 松坂 賢, 島野 仁, et al. 心臓線維芽細胞における脂肪酸伸長酵素Elovl6が圧負荷に伴う心臓リモデリングに及ぼす役割. The Kitakanto Medical Journal. 2023. 73. 3. 244-245
-
佐藤 勇輝, 松井 弘樹, 須永 浩章, 川上 亮, 磯 達也, 石井 秀樹, 横山 知行, 倉林 正彦. Deletion of Fatty Acid Synthase in Vascular Smooth Muscle Cells Attenuates Neointima Formation after Vascular Injury in Mice(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. PJ071-2
-
Huong Nguyen-Thu, Yoshiaki Ohyama, Ayako Taketomi-Takahashi, Tien Nguyen-Cong, Hisako Sumiyoshi, Tetsuya Nakamura, Masahiko Kurabayashi, Yoshito Tsushima. Pulmonary Artery Diameter (PAD) and the Pulmonary Artery to Aorta Ratio (PAD/AAD) as Assessed by Non-contrast Cardiac CT: The Association with Left Ventricular (LV) Remodeling and the LV Function. Internal Medicine. 2022. 61. 12. 1809-1815
ｍore...
MISC (1,462)：
-
原田智成, 小保方優, 表和徳, 岩野弘幸, 吉田くに子, 加藤寿光, 永井利幸, 安斉俊久, 倉林正彦. Importance of Atrial Fibrillation and Right Atrial Remodeling in Functional Tricuspid Regurgitation in Heart Failure with Preserved Ejection Fraction. 日本循環器学会学術集会(Web). 2021. 85th
-
須永浩章, 倉林正彦, 松井弘樹, 横山知行, 松坂賢, 島野仁. INVESTIGATION OF A POTENTIAL MECHANISTIC LINK BETWEEN FATTY ACID COMPOSITION AND ONSET OR DEVELOPMENT OF HEART FAILURE. 日本心臓血圧研究振興会研究業績集. 2019. 34
-
原田智成, 反町秀美, 吉田くに子, 倉林正彦, 根岸一明. Regional Heterogeneity in the Effect of Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review and Meta-Analysis. 日本循環器学会学術集会(Web). 2019. 83rd
-
須永浩章, 倉林正彦, 松井弘樹, 横山知行, 松坂賢, 島野仁. 血管平滑筋細胞の脂肪酸代謝を標的とする新規の動脈硬化症予防・治療戦略. 医科学応用研究財団研究報告(CD-ROM). 2019. 36
-
須永浩章, 須永浩章, 齊藤美希, 松井弘樹, 前野敏孝, 増淵裕朗, 磯達也, 倉林正彦, 横山知行. 喫煙曝露肺気腫モデルにおける脂肪酸組成および脂肪酸伸長酵素Elovl6の病態意義. 日本呼吸器学会誌(Web). 2019. 8
ｍore...
Lectures and oral presentations (240)：
-
強皮症に合併した間質性肺炎の臨床的検討
(第55回日本呼吸器学会学術集会 2015)
-
Clinically amyopathic dermatomyositisに伴う間質性肺炎の臨床的検討
(第55回日本呼吸器学会学術集会 2015)
-
循環器疾患を合併したCOPD患者の治療に関する検討
(第55回日本呼吸器学会学術集会 2015)
-
呼吸器疾患患者における血清オステオプロテジェリン測定の有用性の検討
(第55回日本呼吸器学会学術集会 2015)
-
単結節型肺野病変を呈したサルコイドーシスの臨床的検討
(第55回日本呼吸器学会学術集会 2015)
ｍore...
Education (2)：
- - 1981 The University of Tokyo Faculty of Medicine School of Medicine
- - 1981 The University of Tokyo Faculty of Medicine School of Medicine
Professional career (1)：
- (BLANK) (The University of Tokyo)
Work history (8)：
Awards (6)：
- 1998 - ベルツ賞
- 1998 - Bertz Awrd
- 1992/11 - 米国心臓学会基礎科学部門 Katz Award
- 1992 - American Heart Association, Basic Science Lous N Katz Award
- 1990/03 - 日本循環器学会, Young Investigator's Award
- 1990/03 - Japanese Circulation Society, Young Investigator's Award
Show all
Return to Previous Page
