Rchr

J-GLOBAL ID：200901074782040156 Update date: Mar. 09, 2026

Rakugi Hiromi

ラクギヒロミ | Rakugi Hiromi

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.med.osaka-u.ac.jp/pub/geriat/www/index.html

Research field (4)： Metabolism and endocrinology , Nephrology , Cardiology , Internal medicine - General

Research keywords (5)：高血圧学 , 老年医学 , Hypertensinology , Vascular Medicine , Geriatric Medicine

Research theme for competitive and other funds (54)：

2022 - 2025 高齢者のCOVID-19感染リスクを安全に低下し得る新規戦略の開発
2022 - 2025 高齢者糖尿病のオートファジー機能を反映するバイオマーカーの確立と標的治療法の開発
2021 - 2025 タウ病理の脳内進展過程を標的とした認知症の層別化・個別化治療に向けた基盤的研究
2021 - 2025 タウ病理の脳内進展過程を標的とした認知症の層別化・個別化治療に向けた基盤的研究
2020 - 2024 Translational research for regulation of senescence in association with tryptophan metabolism

2020 - 2023 ビタミンD補充によるサルコペニア治療の可能性を探る

2020 - 2023 Clarification of the role of Interleukin-15 for the efficacy of exercise on physiological conditions promoting sarcopenia

2018 - 2021 Development of novel immunotherapy for chronic inflammatory diseases

2018 - 2021 肥満に伴う脂肪炎症でのマクロファージのリソソーム関連分子myoferlinの機能

2018 - 2020 慢性炎症疾患におけるバイセクト糖鎖の役割

2017 - 2020 高齢者糖尿病における高血糖の是正が骨格筋に及ぼす影響に関する多面的検討

2016 - 2019 A comprehensive study related to the mechanism and usefulness of pre-operative intervention on physical frailty as a poor prognostic factor after surgery for gastrointestinal cancer in older adults

2016 - 2019 Exploratory research for biomarkers to diagnose and predict treatment effect in patients with obstructive sleep apnea

2015 - 2018 Translational research of therapeutic vaccine to improve the quality of anti-hypertensive therapy

2015 - 2018 Research about optimal target blood pressure in very old population

2015 - 2018 The development of the clinical course and the animal model of Alzheimer's disease dementia with cerebrovascular disease

2015 - 2018 Exploratory research for plasma biomarkers to predict a future exploratory research in patients with mild cognitive impairment

2015 - 2018 Functional analysis of macrophage CYLD in age-related atherogenesis

2014 - 2018 Basic research for the clinical application of drugs for a life style disease to treat Alzheimer's disease.

2014 - 2018 Prevention of Metabolic syndrome by Apop gene regulation

2014 - 2017 The elucidation of the mechanism for regulating gene expression in metabolic syndrome in the eldrly.

2014 - 2017 Functional screening for novel molecules related to endothelial dysfunction in the ubiquitin system and the potential of their clinical application.

2013 - 2016 Population studies regarding genetic background on progression of hypertension and antihypertensive drug effect based on self-measured home blood pressure

2013 - 2016 The significance of activation of muscle mitochondrial function in sarcopenic obesity

2013 - 2016 At the attempted suicides of secondary prevention effect of strengthening medical social worker intervention

2014 - 2015 Evaluation of hypertension vaccine using pig model

2012 - 2015 Epigenetic analysis of the dementia progression in the sleep disordered breathing patients

2010 - 2014 Analysis of novel molecule in aging and metabolism toward translational research

2011 - 2013 Is angiotensin II receptor activation involved in the mechanism and pathophysiological role of oxidized LDL?

2011 - 2013 Cross link between diabetes mellitus and bone metabolism in the aspect of renin angiotensin system

2011 - 2013 Interaction of cognitive function and glucose metabolism -angiotenisn IV and IRAP system as a new therapeutic target-

2011 - 2013 Creation of the anti-aging therapy that assumed Apop gene as a target

2011 - 2012 The establishment of animal model for sarcopenia and clarification of the mechanism of sarcopenia: An investigation using an animal model for chronic obstructive pulmonary diseases

2010 - 2012 The role of skeletal muscle metabolism in sarcopenia: An investigation using an animal model for muscle atrophy

2010 - 2012 Genetic influence of genes related to aging on successful aging

2009 - 2012 Analysis of regulatory molecule on vascular aging

2009 - 2012 Analysis of the ageing mechanism induced by Apop

2008 - 2010 Applied Reserch of Apop protein for the treatment of Atherosclerosis

2006 - 2008 The establishment of telomerase control technology and applicationfor medical regeneration

2006 - 2007 The protective effect of Klotho protein from vascular senescence adipocyte differentiation and endothelial function

2003 - 2004 Functional analysis of senescence related Klotho gene and its application for the therapy

2002 - 2004 Gene-Enviromental Interaction of Hypertension

2001 - 2002 Cell biological study on the genetic contribution in human atherosclerosis

1998 - 1999 Evaluation of the role of central neurotrans mitter in animal hypertension models due to hyperactivity of the brain renin-angiotensin system.

1996 - 1997 Role of vascular angiotensin-generating system in atherosclerosis and acute coronary syndrome : Specifoc role of macrophages and smooth muscle cells

1995 - 1997 Causative role of amino acids as neurotransmitters in the ventrolateral medulla for the development of hypertension in the rat

1995 - 1997 Gene analysis of hypertension and development of new therapy

1996 - 1996 抗原利用型遺伝子導入法の開発とおとり型核酸医薬を用いたがん遺伝子治療に関する研究

1995 - 1995 心血管病におけるアンジオテンシン変換酵素の遺伝子多型とその病態生理的意義の検討

1994 - 1994 高血圧での血管壁再構築における機械的伸展刺激の影響に関する分子機構の研究

1992 - 1994 Molecular Research of the Etiology and Treatment of Hypertension

血管老化制御の分子生物学的研究

高血圧,動脈硬化の病態・成因に関する研究

Study on pathophysiology of hypertension and arteriosclerosis

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Papers (1,159)：

Hisatomi Arima, Hiroshi Itoh, Takayoshi Ohkubo, Yusuke Ohya, Mai Kabayama, Takuya Kishi, Nobuhito Hirawa, Katsuyuki Miura, Shin-Ichiro Miura, Koichi Yamamoto, et al. The Japanese Society of Hypertension Guidelines for blood pressure control using digital technologies. Hypertension research : official journal of the Japanese Society of Hypertension. 2026
Ken Sugimoto, Hidetaka Wakabayashi, Junko Ueshima, Fumihiko Nagano, Tatsuro Inoue, Keisuke Maeda, Koichi Yamamoto, Hiromi Rakugi, Masahiro Akishita, Hidenori Arai. <scp>HQ8</scp> : Do Nutritional Interventions Prevent the Onset and Progression of Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty. Geriatrics & Gerontology International. 2026. 26. 1
Kazuomi Kario, Akira Nishiyama, Shigeru Shibata, Satoko Nakamura, Takuya Kishi, Mari Ishida, Satoshi Hoshide, Masaki Mogi, Katsuyuki Miura, Hisatomi Arima, et al. “Morning BP Action in Winter” initiative: confronting cardiovascular “heat shock”. Hypertension Research. 2026
Taku Fujimoto, Hiroshi Akasaka, Yukiko Yasunobe, Shino Yoshida, Yuri Onishi, Tomohiro Minami, Ken Terashima, Mari Shirai, Masaaki Isaka, Minoru Tanaka, et al. Pre-Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial. Geriatrics & gerontology international. 2025. 25. 12. 1765-1773
Kazuomi Kario, Akira Nishiyama, Shigeru Shibata, Masaki Mogi, Hisatomi Arima, Takuya Kishi, Mari Ishida, Masato Furuhashi, Atsuhiro Ichihara, Tomohiro Katsuya, et al. The JSH Morning Hypertension Eradication Program Project. Hypertension research : official journal of the Japanese Society of Hypertension. 2025. 48. 11. 2771-2780

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MISC (1,316)：

竹下ひかり, 竹下ひかり, 加瀬義高, 加瀬義高, 加瀬義高, 平野千尋, 樂木宏実, 小川純人, 山本浩一. アンジオテンシン変換酵素2によるトリプトファン代謝を介した老化制御機構の解明. 日本老年医学会雑誌(Web). 2025. 62
竹下ひかり, 加瀬義高, 樂木宏実, 小川純人, 山本浩一. アンジオテンシン変換酵素IIの老化制御機能のメカニズム解明を目指した基礎的検討. 日本老年医学会雑誌(Web). 2025. 62
竹下ひかり, 竹下ひかり, 樂木宏実, 山本浩一. Basic Study to Elucidate the Mechanism of Angiotensin Converting Enzyme 2 Anti-Ageing Action. 日本高血圧学会総会プログラム・抄録集(CD-ROM). 2024. 46th
竹下ひかり, 樂木宏実, 山本浩一. 腸管特異的アンジオテンシン変換酵素2(ACE2)欠損マウスは早期からの筋力低下を呈する. 日本老年医学会雑誌(Web). 2024. 61
竹下ひかり, 竹下ひかり, 樂木宏実, 山本浩一. アンジオテンシン変換酵素2(ACE2)の老化制御における役割の機序解明に向けた基礎的検討. 日本抗加齢医学会総会プログラム・抄録集. 2024. 24th

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Books (15)：

循環器系と健康長寿・フレイル対策
先端医学社 2022 ISBN:9784865504606
生活習慣病と健康長寿・フレイル対策
先端医学社 2021 ISBN:9784865504576
「100年ライフ」のサイエンス : 老化はこうして制御する
日経BP,日経BPマーケティング (発売) 2020 ISBN:9784296106905
呼吸器系と健康長寿・フレイル対策
先端医学社 2020 ISBN:9784865504514
聴平衡覚と健康長寿・フレイル対策
先端医学社 2019 ISBN:9784865503913

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Lectures and oral presentations (12)：

日本高血圧学会による高血圧治療ガイドライン2019 年版のキーメッセージ
(中西医結合高血圧国際シンポジウム 2019)
高齢者の多様な病態を意識した高血圧診療のポイント
(第36 回滋賀医学会総会 2019)
高血圧治療新ガイドライン:家庭血圧の重要性など
(大阪府内科医会第24 回推薦医部会講演会 2019)
人生100 年時代の高齢者医療の展望
(第44 回金沢市医師会学術セミナー 2019)
健やかな血管を保つための血圧管理
(第51 回日本動脈硬化学会 2019)

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Education (1)：

- 1984 Osaka University Faculty of Medicine

Professional career (1)：

Medical Doctor (Osaka University)

Work history (1)：

2007/11 - 現在 Osaka University Geriatric and General Medicine Professor

Committee career (18)：

2019/06 - 現在吹田市医師会理事
2019/04 - 現在日本心臓病学会代議員
2019/04 - 現在阪大医師会阪大医師会長
2020/10 - 2022/10 日本高血圧学会理事長
2007 - 日本高血圧学会高血圧治療ガイドライン作成委員会事務局長

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Association Membership(s) (23)：

日本臨床分子医学会 , 高血圧関連疾患モデル学会 , 日本腎臓学会 , International Society of Hypertension , 日本心脈管作動物質学会 , American Society of Hypertension , High Blood Pressure Council of American Heart Association , American Heart Association , 日本臨床生理学会 , 日本心血管内分泌代謝学会 , 日本腎臓病学会 , 日本内分泌学会 , 日本老年医学会 , 日本内科学会 , 日本循環器学会 , 日本高血圧学会 , International Society of Hypertension , American Society of Hypertension , High Blood Pressure Council of American Heart Association , American Heart Association , 日本心臓病学会 , 日本サルコペニア・フレイル学会 , 日本老年薬学会

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