Rakugi Hiromi

2020 - 2023 Clarification of the role of Interleukin-15 for the efficacy of exercise on physiological conditions promoting sarcopenia

2018 - 2021 Development of novel immunotherapy for chronic inflammatory diseases

2018 - 2021 肥満に伴う脂肪炎症でのマクロファージのリソソーム関連分子myoferlinの機能

2018 - 2020 慢性炎症疾患におけるバイセクト糖鎖の役割

2017 - 2020 高齢者糖尿病における高血糖の是正が骨格筋に及ぼす影響に関する多面的検討

2016 - 2019 A comprehensive study related to the mechanism and usefulness of pre-operative intervention on physical frailty as a poor prognostic factor after surgery for gastrointestinal cancer in older adults

2016 - 2019 Exploratory research for biomarkers to diagnose and predict treatment effect in patients with obstructive sleep apnea

2015 - 2018 Translational research of therapeutic vaccine to improve the quality of anti-hypertensive therapy

2015 - 2018 Research about optimal target blood pressure in very old population

2015 - 2018 The development of the clinical course and the animal model of Alzheimer's disease dementia with cerebrovascular disease

2015 - 2018 Exploratory research for plasma biomarkers to predict a future exploratory research in patients with mild cognitive impairment

2015 - 2018 Functional analysis of macrophage CYLD in age-related atherogenesis

2014 - 2018 Basic research for the clinical application of drugs for a life style disease to treat Alzheimer's disease.

2014 - 2018 Prevention of Metabolic syndrome by Apop gene regulation

2014 - 2017 The elucidation of the mechanism for regulating gene expression in metabolic syndrome in the eldrly.

2014 - 2017 Functional screening for novel molecules related to endothelial dysfunction in the ubiquitin system and the potential of their clinical application.

2013 - 2016 Population studies regarding genetic background on progression of hypertension and antihypertensive drug effect based on self-measured home blood pressure

2013 - 2016 The significance of activation of muscle mitochondrial function in sarcopenic obesity

2013 - 2016 At the attempted suicides of secondary prevention effect of strengthening medical social worker intervention

2014 - 2015 Evaluation of hypertension vaccine using pig model

2012 - 2015 Epigenetic analysis of the dementia progression in the sleep disordered breathing patients

2010 - 2014 Analysis of novel molecule in aging and metabolism toward translational research

2011 - 2013 Is angiotensin II receptor activation involved in the mechanism and pathophysiological role of oxidized LDL?

2011 - 2013 Cross link between diabetes mellitus and bone metabolism in the aspect of renin angiotensin system

2011 - 2013 Interaction of cognitive function and glucose metabolism -angiotenisn IV and IRAP system as a new therapeutic target-

2011 - 2013 Creation of the anti-aging therapy that assumed Apop gene as a target

2011 - 2012 The establishment of animal model for sarcopenia and clarification of the mechanism of sarcopenia: An investigation using an animal model for chronic obstructive pulmonary diseases

2010 - 2012 The role of skeletal muscle metabolism in sarcopenia: An investigation using an animal model for muscle atrophy

2010 - 2012 Genetic influence of genes related to aging on successful aging

2009 - 2012 Analysis of regulatory molecule on vascular aging

2009 - 2012 Analysis of the ageing mechanism induced by Apop

2008 - 2010 Applied Reserch of Apop protein for the treatment of Atherosclerosis

2006 - 2008 The establishment of telomerase control technology and applicationfor medical regeneration

2006 - 2007 The protective effect of Klotho protein from vascular senescence adipocyte differentiation and endothelial function

2003 - 2004 Functional analysis of senescence related Klotho gene and its application for the therapy

2002 - 2004 Gene-Enviromental Interaction of Hypertension

2001 - 2002 Cell biological study on the genetic contribution in human atherosclerosis

1998 - 1999 Evaluation of the role of central neurotrans mitter in animal hypertension models due to hyperactivity of the brain renin-angiotensin system.

1996 - 1997 Role of vascular angiotensin-generating system in atherosclerosis and acute coronary syndrome : Specifoc role of macrophages and smooth muscle cells

1995 - 1997 Causative role of amino acids as neurotransmitters in the ventrolateral medulla for the development of hypertension in the rat

1995 - 1997 Gene analysis of hypertension and development of new therapy

1996 - 1996 抗原利用型遺伝子導入法の開発とおとり型核酸医薬を用いたがん遺伝子治療に関する研究

1995 - 1995 心血管病におけるアンジオテンシン変換酵素の遺伝子多型とその病態生理的意義の検討

1994 - 1994 高血圧での血管壁再構築における機械的伸展刺激の影響に関する分子機構の研究

1992 - 1994 Molecular Research of the Etiology and Treatment of Hypertension

血管老化制御の分子生物学的研究

高血圧,動脈硬化の病態・成因に関する研究

Study on pathophysiology of hypertension and arteriosclerosis