Tsutsui Hiroko

ツツイヒロコ | Tsutsui Hiroko

Affiliation and department：
Job title： Professor

Research field (4)： Allergies and connective tissue disease , Gastroenterology , Immunology , Bacteriology

Research keywords (8)： Fulminant hepatitis , Atopic diseases , Interleukin 1 family , Host response to bacterial infection , Caspases , IL-18 , IL-33 , Activation of caspase-1

Research theme for competitive and other funds (52)：

2021 - 2024 Analysis of molecular mechanisum of pancreatic cancer cell death and immune responce after carbon ion radiiation and its application to surgery
2018 - 2021 Molecular mechanisms of regulation of abdominal adhesion formation by anti-IL-6 antibody.
2014 - 2017 Mechanism of Fas-mediated inflammatory response against bacterial infection in vivo
2014 - 2016 Dermatitis and activation of IL-33
2013 - 2016 慢性間疾患における肝細胞障害と肝内凝固亢進状態の関連性に関する検討

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Papers (228)：

Makoto Sudo, Hiroko Tsutsui, Shuhei Hayashi, Koubun Yasuda, Keiko Mitani, Nana Iwami, Makoto Anzai, Toshiro Tsubouchi, Mitsuaki Ishida, Sohei Satoi, et al. Autophagy Inhibition Increased Sensitivity of Pancreatic Cancer Cells to Carbon Ion Radiotherapy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2023. 57. 4. 212-225
Naoki Uyama, Hiroko Tsutsui, Songtao Wu, Koubun Yasuda, Etsuro Hatano, Xian-Yang Qin, Soichi Kojima, Jiro Fujimoto. Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation. Scientific reports. 2019. 9. 1. 17558-17558
Rendong Fang, Ryosuke Uchiyama, Shunsuke Sakai, Hideki Hara, Hiroko Tsutsui, Takashi Suda, Masao Mitsuyama, Ikuo Kawamura, Kohsuke Tsuchiya. ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism. Mucosal Immunology. 2019. 12. 5. 1092-1103
Rei Atono Itou, Naoki Uyama, Seiichi Hirota, Norifumi Kawada, Songtao Wu, Seikan Miyashita, Ikuo Nakamura, Kazuhiro Suzumura, Hideaki Sueoka, Tosihiro Okada, et al. Immunohistochemical characterization of cancer-associated fibroblasts at the primary sites and in the metastatic lymph nodes of human intrahepatic cholangiocarcinoma. Human pathology. 2019. 83. 77-89
Fang C, Cai X, Hayashi S, Hao S, Sakiyama H, Wang X, Yang Q, Akira S, Nishiguchi S, Fujiwara N, et al. Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2018. 1864. 3. 271-280

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MISC (220)：

Ryosuke Uchiyama, Hiroko Tsutsui. Caspases as the Key Effectors of Inflammatory Responses Against Bacterial Infection. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS. 2015. 63. 1. 1-13
Hiroko Tsutsui, Xianbin Cai, Shuhei Hayashi. Interleukin-1 Family Cytokines in Liver Diseases. MEDIATORS OF INFLAMMATION. 2015
Hiroko Tsutsui, Shuhei Nishiguchi. Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2014. 15. 5. 7711-7730
Tomohiro Okamoto, Junko Kato, Hiroko Tsutsui, Shuhei Nishiguchi, Jiro Fujimoto. Interferon gamma-mediated tissue factor expression contributes to T cell-mediated hepatitis via induction of hypercoagulation in mice. HEPATOLOGY. 2012. 56. 1115A-1115A
Masahito Tarutani, Yasutomo Imai, Koubun Yasuda, Hiroko Tsutsui, Kenji Nakanishi, Kiyofumi Yamanishi. Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice (vol 58, pg 28, 2010). JOURNAL OF DERMATOLOGICAL SCIENCE. 2010. 59. 1. 63-63

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Books (25)：

宿主と病原体の攻防
”コア免疫学第2版”(木本雅夫、阪口薫雄、山本優毅編集)南山堂 2007
Interleukin-18 [IL-1F4]
Elsevier Science Ltd 2003
IL-18 and IL-18 receptor knockout mice in "Cytokine Knockouts 2nd Edition"
Humana Press Inc. Ttowa NJ 2003
Interleukin-18 in "Encyclopedia of Hormones"
Academic Press 2003
自己免疫
"免疫学コア講義 " 南山堂 2002

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Works (6)：

シグナル抑制因子SOCS-1の欠除に基く肝障害の発症機構の解析
1998 -
Molecularmechanisms of severe hepatitis in SOCS-1-deficient mice
1998 -
caspase-1欠損マウスにみられるListeria monocytogenesの排菌異常
1997 -
IL-18過剰発現によるアトピー性ヒフ炎の誘導
1997 -
Impairment of listerial clearance in caspase-1-deficient mice
1997 -

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Education (2)：

- 1985 Osaka City University Medical School
- 1981 Osaka City University Medical School

Professional career (1)：

Medical Doctor (Osaka City University)

Work history (8)：

2006/04 - 現在 Hyogo Medical University
2006/01 - 2015/03 Hyogo Medical University
2000/01 - 2005/12 Hyogo Medical University Associated Professor
1996 - 2000 Hyogo College of Medicine
2000 - - 兵庫医科大学助教授

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Committee career (2)：

2008 - 現在日本細菌学会評議員
日本免疫学会評議員

Association Membership(s) (10)：

日本感染症学会 , 日本ウイルス学会 , 日本細菌学会 , 日本生化学会 , 日本肝臓学会 , 日本免疫学会 , Japanese Society for Virology , Japanese Society of Liver Diseases , Japanese Society for Bacterology , Japanese Society for Immunoloty

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