Research field (1)：
Applied biofunctional and bioprocess engineering
Research keywords (4)：
Cell-free protein synthesis
, High throughput screening
, enzyme
, antibody
Research theme for competitive and other funds (29)：
2023 - 2025 Establishment of a platform for high-throughput CAR-T cell generation for gastric cancer
2022 - 2025 革新的機能的ヒト抗体配列ーエピトープのハイスループット解析技術開発
2022 - 2025 固相培養条件下の麹菌における遺伝子の動的発現制御機構の解明とその応用
2022 - 2025 腫瘍微小環境内 B 細胞を用いた転移性脳腫瘍に対する CAR-T 細胞療法の開発
2021 - 2024 Development and application of an early detection method for postoperative recurrence of colorectal cancer using tears
2020 - 2023 Elucidation of the mechanism of maturation of tertiary lymph structure in gastric cancer tumor immune microenvironment and identification of the therapeutic antibodies
2019 - 2023 Development of novel monoclonal antibody creation system using AI and single cell technoogy
2019 - 2022 Development of orthgonal liposomal fusion method using artificial phospholipids and its application
2017 - 2021 Simultaneous production of monoclonal antibodies against multiple membrane proteins and their evaluations for the applications to therapeutic medicines
2014 - 2016 無細胞系ナノ構造化生物機能システムの開発
2014 - 2016 Development of a novel immunoassay system using NIR luminescent glass
2011 - 2015 Development and application of Giga-screening system of by-molecules using cell-free biochemical reactions
2011 - 2012 Development of Signal Peptide Optimization Tool
2010 - 2012 Cloud-type Computer Lab for Discipline-Specific Education Using Virtual Computer Laboratory and Its Application
2009 - 2011 Toward REVERSE PROTEOMICS : a selection platform of a peptide fragment that specifically inhibits the targeted protein-protein interaction.
2007 - 2010 Development and application of cell-free molecular display system
2007 - 2008 ヒトモノクローナル抗体のハイスループット取得法の開発
2007 - 2008 免疫細胞ネットワークのデジタル解析
2004 - 2006 Comprehensive analysis of the substrate-binding pocket relating to enantilselectivity of enzyme
2004 - 2005 細胞1個の遺伝情報とリンクしたプロテインアレイシステムの構築
2003 - 2005 Development and application of highly integrated protein and cell chip devices
2000 - 2002 Ultra-highly effective utilization of lipid resources-Enzymatic syntheses of structured lipids-
2000 - 2002 Construction of highly condensed protein/peptide library on micro-reactor array
1999 - 2002 Elucidation of expression/regulation of genes involved in microbial polyhydroxylalkanoate (PHA)
2000 - 2001 ハイスループットモノクローナル抗体取得法に関する研究
1998 - 2001 Development of cell-free gene translator as an equipment to support researches in bioscience and biotechnology
1997 - 1998 CONSTRUCTION OF IN VITRO EVOLUTION SYSTEM OF PROTEINS
1995 - 1997 Studies on Increasing Efficiency of Cell-free Protein Synthesis
1995 - 1996 Enzymatic synthesis of an important building block for the new nicotinyl pesticides
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Papers (41)：
Hiroya Oka, Takaaki Kojima, Ryuji Kato, Kunio Ihara, Hideo Nakano. Construction of transcript regulation mechanism prediction models based on binding motif environment of transcription factor AoXlnR in Aspergillus oryzae. Journal of bioinformatics and computational biology. 2024. 22. 3. 2450017-2450017
Beixi Jia, Teruyo Ojima-Kato, Takaaki Kojima, Hideo Nakano. Rapid and cost-effective epitope mapping using PURE ribosome display coupled with next-generation sequencing and bioinformatics. Journal of bioscience and bioengineering. 2024
Teruyo Ojima-Kato, Yuma Nishikawa, Yuki Furukawa, Takaaki Kojima, Hideo Nakano. Nascent MSKIK Peptide Cancels Ribosomal Stalling by Arrest Peptides in Escherichia coli. Journal of Biological Chemistry. 2023. 104676-104676
Jasmina Damnjanović, Nana Odake, Jicheng Fan, Maurizio Camagna, Beixi Jia, Takaaki Kojima, Naoto Nemoto, Kiyotaka Hitomi, Hideo Nakano. Comprehensive analysis of transglutaminase substrate preference by cDNA display coupled with next-generation sequencing and bioinformatics. Scientific Reports. 2022. 12. 1
