2025 - 2026 Protein engineering of D-amino acid oxidase and transglutaminase using novel single-molecule display technology coupled with Nanopore sequencing
2023 - 2025 Establishment of a platform for high-throughput CAR-T cell generation for gastric cancer
2022 - 2025 革新的機能的ヒト抗体配列ーエピトープのハイスループット解析技術開発
2022 - 2025 固相培養条件下の麹菌における遺伝子の動的発現制御機構の解明とその応用
2022 - 2025 腫瘍微小環境内 B 細胞を用いた転移性脳腫瘍に対する CAR-T 細胞療法の開発
2024 - 2025 Development of single-molecule display technology for directed evolution of D-amino acid oxidase with high substrate specificity
2021 - 2024 Development and application of an early detection method for postoperative recurrence of colorectal cancer using tears
2023 - 2024 Development of single molecule display technology for directed evolution of proteins
2020 - 2023 Elucidation of the mechanism of maturation of tertiary lymph structure in gastric cancer tumor immune microenvironment and identification of the therapeutic antibodies
2019 - 2023 Development of novel monoclonal antibody creation system using AI and single cell technoogy
2019 - 2022 Development of orthgonal liposomal fusion method using artificial phospholipids and its application
2017 - 2021 Simultaneous production of monoclonal antibodies against multiple membrane proteins and their evaluations for the applications to therapeutic medicines
2014 - 2016 無細胞系ナノ構造化生物機能システムの開発
2014 - 2016 Development of a novel immunoassay system using NIR luminescent glass
2011 - 2015 Development and application of Giga-screening system of by-molecules using cell-free biochemical reactions
2011 - 2012 Development of Signal Peptide Optimization Tool
2010 - 2012 Cloud-type Computer Lab for Discipline-Specific Education Using Virtual Computer Laboratory and Its Application
2009 - 2011 Toward REVERSE PROTEOMICS : a selection platform of a peptide fragment that specifically inhibits the targeted protein-protein interaction.
2007 - 2010 Development and application of cell-free molecular display system
2007 - 2008 ヒトモノクローナル抗体のハイスループット取得法の開発
2007 - 2008 免疫細胞ネットワークのデジタル解析
2004 - 2006 Comprehensive analysis of the substrate-binding pocket relating to enantilselectivity of enzyme
2004 - 2005 細胞1個の遺伝情報とリンクしたプロテインアレイシステムの構築
2003 - 2005 Development and application of highly integrated protein and cell chip devices
2000 - 2002 Ultra-highly effective utilization of lipid resources-Enzymatic syntheses of structured lipids-
2000 - 2002 Construction of highly condensed protein/peptide library on micro-reactor array
1999 - 2002 Elucidation of expression/regulation of genes involved in microbial polyhydroxylalkanoate (PHA)
2000 - 2001 ハイスループットモノクローナル抗体取得法に関する研究
1998 - 2001 Development of cell-free gene translator as an equipment to support researches in bioscience and biotechnology
1997 - 1998 CONSTRUCTION OF IN VITRO EVOLUTION SYSTEM OF PROTEINS
1995 - 1997 Studies on Increasing Efficiency of Cell-free Protein Synthesis
1995 - 1996 Enzymatic synthesis of an important building block for the new nicotinyl pesticides
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Papers (82)：
Kihara M., Okuda R., Okada A., Ojima-Kato T., Nakano H. Evaluation of antibody variants using a ribosome display and Brevibacillus choshinensis secretion system. Journal of bioscience and bioengineering. 2025
Yuma Nishikawa, Riko Fujikawa, Hideo Nakano, Takashi Kanamori, Teruyo Ojima-Kato. Effect of Translation-Enhancing Nascent SKIK Peptide on the Arrest Peptides Containing Consecutive Proline. ACS Synthetic Biology. 2024
Hiroya Oka, Takaaki Kojima, Ryuji Kato, Kunio Ihara, Hideo Nakano. Construction of transcript regulation mechanism prediction models based on binding motif environment of transcription factor AoXlnR in Aspergillus oryzae. Journal of bioinformatics and computational biology. 2024. 22. 3. 2450017-2450017
T I K Munaweera, Jasmina Damnjanović, Maurizio Camagna, Moeri Nezu, Beixi Jia, Kiyotaka Hitomi, Naoto Nemoto, Hideo Nakano. Substrate profiling of human transglutaminase 1 using cDNA display and next-generation sequencing. BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY. 2024. 88. 6. 620-629
