Rchr
J-GLOBAL ID：200901075007121030
Update date: Nov. 12, 2024
Tanaka Shinji
タナカ シンジ | Tanaka Shinji
Affiliation and department：
Job title：
Assistant Professor
Homepage URL (1)：
http://www.tmd.ac.jp/grad/msrg/
Research field (3)：
Digestive surgery
, General surgery, pediatric surgery
, Pathobiochemistry
Research keywords (6)：
病態医化学
, 外科腫瘍学
, 消化器外科学
, Pathological Medical Chemistry
, Surgical Oncology
, Gastroenterological Surgery
Research theme for competitive and other funds (73)：
- 2022 - 2025 正常免疫マウス腫瘍モデルを応用したヒトスキルス胃がんに対する複合免疫療法の開発
- 2022 - 2025 神経内分泌腫瘍におけるマルチアナライトバイオマーカーの創設と疾患管理
- 2022 - 2025 Establishment of detection technique for schirrous stomach cancer and estimation technique for progress degree in early stomach cancer using circulalry polarized light scattering
- 2021 - 2024 腸内細菌による膵臓癌化学療法抵抗性の機序解明と革新的治療法開発
- 2021 - 2024 膵臓癌における化合物スクリーニングによる新規抗がん剤併用療法の開発と臨床応用
- 2021 - 2024 The molecular mechanism of hepatocellular carcinoma associated fibroblast oriented exosome miRNA
- 2020 - 2023 Envolvement of abnormal of SETDB-related histone modification enzyme and tumor immune environment in gastrointestinal cancer
- 2020 - 2022 Application of multiplex genome editing technology to the development of CAR-T therapy for refractory cancer subtypes
- 2019 - 2022 Noninvasive diagnoses for malignant neuroendocrine neoplasms
- 2019 - 2022 Clarification of diversity mechanisms for innovation of refractory cancer treatment
- 2018 - 2020 Innovation of genome editing technology as the basis to develop molecular subtype panels of intractable cancer
- 2017 - 2020 Analysis based on the progression of pancreatic cancer and validation by prospective clinical trial
- 2016 - 2020 Molecular pathology of SET-related histone methyltransferase in refractory cancer
- 2016 - 2019 Nuclear factor kappa B and tolerance -Immunosuppression of cancer growth and post-organ transplant-
- 2016 - 2019 Develoment of advanced therapy targeting tumor heterogeneity in refractory cancers
- 2015 - 2019 Exploration of novel molecular targets in hapato-bilirary-pancreatic cancers
- 2016 - 2018 Specific kinase analysis and clinicopathological validation in visualized cancer stem cells
- 2015 - 2018 Gene analyses to assess malignant potential of Pancreatic neuroendocrine neoplasms
- 2015 - 2018 Development of new diagnosis shear wave methods for liver fibrosis and steatosis
- 2015 - 2017 可視化がん幹細胞による細胞競合の解析と根治的癌治療開発
- 2015 - 2017 Clinicopathological analysis and investigation of molecular mechanism of pancreatic cancer stemness using visualizing system.
- 2015 - 2017 Analysis of in vivo niches and therapeutic targets for cancer stem cells based on the visualization mechanism
- 2014 - 2017 Development of multidisciplinary therapy for aged liver insufficiency based on the mechanism of hepatic stellate cell dysfunction.
- 2013 - 2016 Exploratory analysis for imaging biomarkers of hepatocellular carcinoma
- 2013 - 2016 Identification and clinical application of pathway-based markers for cancer
- 2013 - 2016 Innovative treatment of refractory digestive cancers based on the stemness visualization system
- 2010 - 2016 Development of Novel Treatment Strategies Targeting Cancer Stem Cells
- 2012 - 2015 Clinical application of inhibition of Nuclear Factor-kappa B: oncogenic proliferation and surgical stress
- 2012 - 2015 The fragility of macrovesicular fatty liver grafts during ischemia reperfusion injury
- 2010 - 2015 Elucidation of dormant cancer stem cells and their niche properties in human solid tumors
- 2011 - 2014 Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation.
- 2011 - 2012 幹細胞機能を基盤とした膵癌幹細胞の病態解析
- 2010 - 2012 Development of the prediction system of the early response of theSorafenib for advanced hepatocellular carcinoma using contrast enhanced ultrasonography
- 2010 - 2012 Innovation of cancer treatment based on the refractory mechanism
- 2011 - 2011 二つの幹細胞特性に基づく肝癌病態解析
- 2008 - 2011 Study on the molecular diagnosis of metastasis and recurrence and molecular targeted therapy for intractable hepato-pancreatic cancer
- 2008 - 2010 脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発
- 2007 - 2009 Omics analysis of cancer vessel abnormalities as therapeutic targets
- 2005 - 2009 Cancer stem cells and genes responsible for their development in hematopoietic system
- 2006 - 2007 Multidisciplinary research for molecular mechanism of cancer progression and development of diagnostic and therapeutic tool
- 2005 - 2006 Analysis of novel angiogenesis-related genes and development of tumor dormancy therapy
- 2004 - 2005 Development of molecular- targeting therapy and prediction of mode of recurrence by analysis of molecular mechanism of invasion and metastasis of hepatocellular carcinoma
- 2004 - 2004 新たに同定した血管新生関連遺伝子群の解析とその制御による癌冬眼化治療の開発
- 2002 - 2004 Promotion of liver regeneration and intrahepatic metastasis of hepatocellular carcinoma by Histone acetylation
- 2003 - 2003 新規Wnt/Fzシグナル誘導分子WISP、制御分子Dkk、Kremenの解析
- 2002 - 2003 Identification of differentiation regulated gene and application to differentiation inducing gene therapy
- 2002 - 2003 Analysis of newly identified anglogenic genes and the signal inhibition for tumor dormancy therapy
- 2002 - 2002 新たにクローニングしたWnt/Fzシグナル誘導癌遺伝子と機能抑制遺伝子の解析
- 2001 - 2002 Wider application of small-for-size partial liver grafting by gene transfer using teromerase reverse transcriptase (TERT).
- 2001 - 2002 Development of a super liver graft resistant to various kinds of injuries by a gene-transfer technique
- 2001 - 2001 癌化シグナル伝達Wnt/Fzに関与する新しいがん関連遺伝子の解析
- 2000 - 2001 Regulation of multiple angiogenic signaling and development of cancer-specific gene therapy
- 2000 - 2001 Development of a Hybrid Artificial Liver for Treatment of Acute and Chronic Liver Failure Patients
- 2000 - 2001 エレクトロポレーション法を用いた新たな肝細胞癌に対する遺伝子治療の開発
- 2000 - 2000 癌化シグナル伝達Wnt/Fzを制御する新しいがん関連遺伝子の同定とその機能解析
- 1999 - 1999 新しい癌血管新生因子angiopoietinファミリーのシグナル伝達制御による癌治療の試み
- 1999 - 1999 新しい癌関連遺伝子FzE3シグナル伝達系におけるターゲット遺伝子の同定とその制御
- 1998 - 1999 pH regulating therapy for hepatocellular carcinoma
- 1998 - 1999 Clinical significance of molecular detection of carcinoma cells
- 1998 - 1998 癌化シグナル伝達抑制分子による新しい癌治療の試み
- 1998 - 1998 癌抑制遺伝子における遺伝子欠失機構の解明
- 1997 - 1998 癌転移におけるシグナル伝達解析と転移規定分子の同定による抑制治療の開発
- 1997 - 1998 The research for the mechanism of resistance to catalytic topoisomerase II inhibitors
- 1997 - 1998 BASIC RESEARCH FOR TUMOR SPECIFIC IMMUNOTHERAPY USING TUMOR REJECTED ANTIGEN GENES
- 血管新生の解析と分子標的治療の開発
- 癌幹細胞の解析と分子標的治療の開発
- 消化器癌の分子解析と標的治療の開発
- 癌遺伝子治療の研究
- 癌転移の分子生物学的解析
- 癌化シグナル伝達の分子生物学的解析
- Study of Gene Therapy for Cancer
- Molecular Analysis of tumor metastasis
- Molecular Analysis of Oncogenic Signal Tnansduction
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Papers (222)：
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Shu Shimada, Shinji Tanaka. The chronicles of hepatocellular carcinoma classification: Subtyping, modeling, and treatment. Hepatology (Baltimore, Md.). 2024. 79. 2. 261-263
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梅村 謙太郎, 秋山 好光, 島田 周, 羽多野 恵, 安川 紘矢, 蒲池 厚志, 田邉 稔, 田中 真二. 膵癌の新規エピゲノム異常の解明と標的治療の開発. 日本消化器外科学会雑誌. 2023. 56. Suppl.2. 545-545
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Megumi Hatano, Yoshimitsu Akiyama, Shu Shimada, Kohei Yagi, Keiichi Akahoshi, Michiko Itoh, Minoru Tanabe, Yoshihiro Ogawa, Shinji Tanaka. Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC. Hepatology communications. 2023. 7. 10
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安川 紘矢, 島田 周, 秋山 好光, 田中 真二. 肝癌における免疫治療抵抗性の解明 乳酸代謝からみた新規治療法への展開(Elucidation of immunotherapy resistance in hepatocellular carcinoma: Novel treatment based on lactate metabolism). 日本癌学会総会記事. 2023. 82回. 1147-1147
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Momoko Ichihara, Hidekazu Takahashi, Naohiro Nishida, Cristina Ivan, Daisuke Okuzaki, Yuhki Yokoyama, Masahisa Ohtsuka, Norikatsu Miyoshi, Mamoru Uemura, Shinji Tanaka, et al. Long noncoding RNA 01534 maintains cancer stemness by downregulating endoplasmic reticulum stress response in colorectal cancer. Annals of Gastroenterological Surgery. 2022. 7. 3. 458-470
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MISC (335)：
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安川紘矢, 安川紘矢, 島田周, 秋山好光, 田中真二. Elucidation of immunotherapy resistance in hepatocellular carcinoma: Novel treatment based on lactate metabolism. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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安川 紘矢, 秋山 好光, 島田 周, 田中 真二. 胆道癌の分子生物学的サブタイプと治療戦略-Molecular subtypes and molecular targeted therapy in cholangiocarcinoma-特集 胆道疾患研究最前線. 消化器・肝臓内科 = Gastroenterology & hepatology / 消化器・肝臓内科編集委員会 編. 2022. 11. 1. 33-42
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田中真二, 島田周, 秋山好光, 大庭篤志, 渡辺秀一, 奥野圭祐, 水野裕貴, 上田浩樹, 吉野潤, 菅原了子, et al. ゲノム医療・ゲノム編集時代におけるプレシジョン免疫複合療法. 日本外科学会定期学術集会(Web). 2019. 119th
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Shu Shimada, Yoshimitsu Akiyama, Hiroshi Fukamachi, Yasuhito Yuasa, Shinji Tanaka. Identification of selective inhibitors of diffuse-type gastric cancer cells by screening of annotated compounds. CANCER RESEARCH. 2016. 76
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Treatment strategy for liver metastasis of pancreatic neuroendocrine neoplasms. 2016. 33. 2. 105-109
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Patents (2)：
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Inhibition of oncogenic signals
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Inhibition of oncogenic signals
Professional career (1)：
Committee career (1)：
- 2019/04 - 現在 JSPS RCSS Senior Program Officer
Awards (11)：
- 2013 - 日本消化器外科学会賞(第一回学術部門) JSGS Science of the Year 2013
- 2012 - 日本癌学会 学術賞JCA-Mauvernay Award
- 2007 - IRPC “Gold Medal”, Eminent Scientist of the Year
- 2006 - 日本学術振興会賞
- 2006 - JSPS Prize
- 1999 - 日本癌学会奨励賞
- 1999 - Fukoka Medical Award
- 1999 - Incitement Award, Japan Cancer Society
- 1997 - Medical Research Award, Japan Medical Association
- 1996 - AASLD Young Investigator Award (アメリカ肝臓病学会・若年研究者賞)
- 1996 - Young Investigator Award, American Association of Study of Liver Diseases
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Association Membership(s) (4)：
米国癌学会
, 日本消化器外科学会
, 日本癌学会
, 日本外科学会
