Okano Hirotaka James

オカノジェイムスヒロタカ | Okano Hirotaka James

Affiliation and department：
Job title： Professor and Director

Research field (1)： Neuroscience - general

Research keywords (7)： Parkinson's disease , ischemic disease , ALS , iPS cell , RNA binding protein , neuronal differentiation , neurodegenerative disease

Research theme for competitive and other funds (25)：

2023 - 2026 ALSにおける運動ニューロン特異的スプライシング制御機構の解明
2022 - 2025 Integrated understanding of the brain network: from auditory perception
2022 - 2025 TARP症候群のiPS細胞および動物モデルを用いた神経学的症状の病態解明
2021 - 2024 IoTセンシングとiPS細胞研究の融合による内耳障害の統合的理解と次世代型創薬
2021 - 2024 Enhancing thrombolytic therapy using clinical ultrasound with micro bubble contrast agent

2021 - 2024 家族性パーキンソン病PARK17由来iPS細胞を用いた根幹病態の解明と治療薬開発

2020 - 2023 NIRSを用いた高次脳活動時の脳血液量増加持続時間の解析

2018 - 2023 Influence of high concentrated oxygen inhalation on cerebral blood flow during higher brain functioning

2017 - 2023 Visualizing the olfactory map with diffusion tensor imaging: Development of an objective olfactory test method

2018 - 2021 Development of novel therapeutics for the cochlear hearing impairments by using hiPSCs and common marmoset models

2017 - 2020 AR-navigated transcanal endoscopic inner ear sugery

2017 - 2020 Establishment of RNA-based Biomarkers for ALS

2015 - 2018 Pre-clinical proof of concept trials for auditory hair cell regeneration by using hiPSC technology and marmoset model

2015 - 2017 Effects of high-energy particles on neural activity

2015 - 2017 Pathogenesis of schizophrenia using neural induction system from iPS Cell

2014 - 2016 遅発性小脳失調モデル動物を用いた軸索変性機序の解明

2012 - 2015 Analyses of regulatory mechanisms of TDP-43 level and risk factor of ALS

2012 - 2014 遅発性小脳失調モデル動物を用いた軸索変性機序の解明

2009 - 2010 神経特異的ユビキチンリガーゼKspotによるシナプス制御

2005 - 2009 Regulation of neuronal differentiation and plasticity at posttranscriptional level

2007 - 2008 中枢神経特異的ユビキチンリガーゼKspotによるシナプス制御

2004 - 2005 The Role of RNA Binding Protein Hu in Neuronal Differentiation

2004 - 2004 p27Kipl mRNA非翻訳領域SNPと翻訳促進活性・癌危険度との関連

2002 - 2003 Experimental studies on peripheral nerve regeneration through the bio-nerve with 3D cultured Schwann cell

2002 - 2003 The Role of RNA Binding Protein Hu in pathophysiology of the paraneoplastic neurologic disorders (PND's)

Show all

Papers (175)：

Shiraishi T, Bono K, Hiraki H, Manome Y, Oka H, Iguchi Y, Hirotaka James Okano. The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease. Cellular and molecular life sciences : CMLS. 2024. 81. 1. 103
Yuta Kurashina, Kurihara S, Kubota T, Takatsuka S, Hirabayashi M, Shinmura H, Miyahara H, Hioki A, Matsushita Y, Muramatsu J, et al. Adeno-Associated Virus-Encapsulated Alginate Microspheres Loaded in Collagen Gel Carriers for Localized Gene Transfer. Advanced healthcare materials. 2024. e2303546
Mohamed Darwish, Satoko Suzuki, Yuki Ogawa, Akinori Takase, Masami Tanaka, Yoko Iijima, Yuji Sato, Mariko Suzuki, Yumi Kanegae, Chisa Okada, et al. Activity-regulated micro-exon splicing programs underlie late-onset plasticity at the axon initial segment. 2023
Tomotaka Shiraishi, Daisuke Yoshimaru, Tadashi Umehara, Masakazu Ozawa, Shusaku Omoto, Motohiro Okumura, Tatsushi Kokubu, Junichiro Takahashi, Takeo Sato, Asako Onda, et al. Interactive effect of orthostatic hypotension on gray matter atrophy associated with hyposmia and RBD in de novo Parkinson’s disease. Journal of Neurology. 2023. 270. 12. 5924-5934
Shuhei Takatsuka, Takeshi Kubota, Yuta Kurashina, Sho Kurihara, Motoki Hirabayashi, Masato Fujioka, Hirotaka James Okano, Hiroaki Onoe. Controlled release of adeno-associated virus from alginate hydrogel microbeads with enhanced sensitivity to ultrasound. Biotechnology and bioengineering. 2023. 120. 8. 2371-2377

ｍore...

MISC (101)：

福島宗一郎, 福島宗一郎, 岩井良輔, 小泉誠, 長谷川実奈美, 岡野ジェイムス洋尚. セルファイバーを用いた次世代低侵襲再生医療:血管内幹細胞治療の開発. 人工臓器(日本人工臓器学会). 2022. 51. 1
児玉早, 児玉早, 畑純一, 岩楯公晴, 岡野ジェイムス洋尚, 金涌佳雅. 超高磁場9.4TMRI装置を用いて固定脊髄における長軸路描出を試みた3例. 日本法医学会学術全国集会講演要旨集. 2022. 106th
大城日菜子, 大城日菜子, 畑純一, 畑純一, 畑純一, 羽賀柔, 羽賀柔, 林直弥, 林直弥, 吉丸大輔, et al. 微細制限構造における拡散特性の理解. 日本放射線技術学会総会学術大会予稿集. 2021. 77th
飯田真由, 飯田真由, 畑純一, 畑純一, 畑純一, 関布美子, 関布美子, 羽賀柔, 羽賀柔, 吉丸大輔, et al. 非ヒト霊長類の年齢に伴う脳形態特性. 日本放射線技術学会総会学術大会予稿集. 2021. 77th
野武幸子, 野武幸子, 畑純一, 平林源希, 平林源希, 吉丸大輔, 栗原渉, 栗原渉, 岡野ジェイムス洋尚. Analysis with voxel-based meta-analysis of neurodegeneration in the common marmoset model of hearing loss. 東京慈恵会医科大学雑誌. 2021. 136. 6

ｍore...

Lectures and oral presentations (49)：

損傷部脊髄内Semaphorin3A阻害剤による損傷軸索の再生
(第3回日本再生医療学会総会・シンポジウム 2004)
脊髄損傷に対する樹状細胞移植による神経再生
(第2回日本再生医療学会 2003)
脊髄損傷に対する樹状細胞移植による神経再生
(第2回日本再生医療学会総会 2003)
骨髄間葉系多能性幹細胞純化の試み
(第2回日本再生医療学会 2003)
損傷部脊髄内Semaphorin3A阻害剤による損傷軸索の再生
(第10回脊髄末梢神経研究会 2003)

ｍore...

Works (2)：

自主学習小委員会委員
2003 - 2005
カリキュラム委員会委員
2003 - 2005

Professional career (1)：

MD, PhD (The Jikei University Graduate School of Medicine)

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page