Rchr
J-GLOBAL ID：200901075183420583
Update date: Nov. 18, 2024
Shimizu Takahiko
シミズ タカヒコ | Shimizu Takahiko
Affiliation and department：
Research field (3)：
Medical biochemistry
, Applied biochemistry
, Nutrition and health science
Research keywords (8)：
Functional food
, Aging
, Healthy lifespan
, Redox regulation
, Aging stress
, longevity
, Reactive oxygen species
, Oxidative stress
Research theme for competitive and other funds (27)：
- 2020 - 2023 Molecular mechanism of osteocyte senescence by mitochondrial retrograde signaling
- 2017 - 2020 Elucidation of molecular pathology of aging and diseases based on multi-dimensional analysis of progeroid syndromes
- 2014 - 2019 Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta
- 2015 - 2018 Establishment of novel therapies for steatohepatitis and liver cancer, by targeting the free cholesterol-mediated signaling pathway.
- 2014 - 2017 Oxidative stress in bone regulates skeletal homeostasis in mice
- 2014 - 2017 Pathological elucidation of age-related diseases by integrative analyses of senescence genes
- 2013 - 2016 The functional analysis of SOD2, antioxidantdefense in periodontal tissue
- 2013 - 2015 To generate and analyze new Parkinson's disease mice model with increased oxidative stress
- 2012 - 2015 The role of oxidative stress in the maintenance of bone metabolism
- 2011 - 2015 Effects of coenzyme Q on aging in mammls
- 2012 - 2014 Establishment of disease iPS cells and molecular analysis of age-related changes in progeroid syndrome
- 2009 - 2014 Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid beta
- 2010 - 2012 Development of RNA aptamer against toxic Aβ oligomer
- 2010 - 2012 Mitochondria Treatment by Antioxidant with Multi-enzyme Activity
- 2009 - 2011 The development and analyses of the mouse model of age-related osteoporosis.
- 2008 - 2010 Analysis of the paradoxical correlation between hepatic insulin resistance and oxidative stress in the pathogenesis of steatohepatitis
- 2008 - 2010 Oxidative stress in skeletal muscle causes severe disturbance of exercise activity
- 2008 - 2010 Molecular mechanism for aging control
- 2006 - 2008 Development of antibodies and aggregation inhibitors for amyloid β peptides based on the new aggregation model
- 2005 - 2006 酸化ストレスによる神経変性の分子メカニズム解明
- 2005 - 2006 Analysis of heart/muscle-specific Mn-SOD-deficient mice.
- 2005 - 2005 アミロイドβ42凝集体のターン構造をエピトープとしたワクチン療法の開発
- 2004 - 2005 Structural analysis of β-amyloid fibrils using solid-state NMR
- 2003 - 2004 脳酸化ストレス蓄積マウスの作製と解析
- 2001 - 2003 Elucidation of aggregation mechanism of Alzheimer's β-peptides and development of their aggregation inhibitors
- 2001 - 2002 神経変性モデルマウスに蓄積した変性タンパク質の同定
- 1998 - 1999 Identification of isoaspartic acid containing proteins in aged brain
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Papers (192)：
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Shuichi Shibuya, Kenji Watanabe, Daiki Sakuraba, Takeshi Nagata, Yoshimasa Yamaguchi, Yasuyuki Suzuki, Takahiko Shimizu. Geraniol intake improves age-related malnutrition in mice. Geriatrics & Gerontology International. 2024
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Shuichi Shibuya, Kenji Watanabe, Takahiko Shimizu. The Antioxidant PAPLAL Protects against Allergic Contact Dermatitis in Experimental Models. Antioxidants. 2024. 13. 6. 748-748
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Rahmawati Aisyah, Noriyasu Ohshima, Daiki Watanabe, Yoshiko Nakagawa, Tetsushi Sakuma, Felix Nitschke, Minako Nakamura, Koji Sato, Kaori Nakahata, Chihiro Yokoyama, et al. GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice. Communications Biology. 2024. 7. 1
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Shota Tamagawa, Daisuke Sakai, Hidetoshi Nojiri, Yoshihiko Nakamura, Takayuki Warita, Erika Matsushita, Jordy Schol, Hazuki Soma, Shota Ogasawara, Daiki Munesada, et al. SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential. Redox Biology. 2024. 71. 103091-103091
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Naotaka Izuo, Nobuhiro Watanabe, Yoshihiro Noda, Takashi Saito, Takaomi C Saido, Koutaro Yokote, Harumi Hotta, Takahiko Shimizu. Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease. Aging cell. 2023. e13994
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MISC (50)：
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Functional food containing curcumin, ginkgo biloba extract, L-camitine, long pepper extract and astaxanthin and thioredoxin-containing sake extract improve skin atrophy in aging model mice. Functional Food Research. 2024. 20. 62-69
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Extracellular matrix remodeling by matrix metalloproteinase and age-related pathologies. Functional Food Research. 2024. 20. 29-34
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Fundanlentals of anti-aging research. Journal of Mammalian Ova Research. 2023. 40. 2. 27-33
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Exploring for compounds that enhance motor function using muscle fatigue-model mice. 2023. 19. 45-49
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Functional analyses of food materials using progeria models. Functional Food Research. 2023. 19. 5-9
ｍore...
Education (2)：
- Hiroshima University Faculty of Applied Biological Science
- Hiroshima University Graduate School of Biosphere Science
Professional career (1)：
Work history (5)：
- 2024 - 現在 順天堂大学大学院 医学研究科
- 2019 - 2024 National Center for Geriatrics and Gerontology
- 2011 - 2019 Chiba University Graduate School of Medicine
- 2003 - 2011 Tokyo University of Agriculture and Technology
- 1997 - 2011 Tokyo Metropolitan Institute of Gerontology
Committee career (5)：
- 2021 - 現在 ファンクショナルフード学会 理事、副理事長
- 2015 - 現在 日本基礎老化学会 理事
- 2007 - 現在 日本抗加齢医学会 評議員
- 2015 - 2019 日本基礎老化学会 編集委員長
- 2012 - 2015 日本基礎老化学会 評議員
Association Membership(s) (6)：
日本抗加齢医学会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY
, 日本生化学会
, ファンクショナルフード学会
, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
