Rchr
J-GLOBAL ID：200901075183420583   Update date: Feb. 14, 2024

Shimizu Takahiko

シミズ タカヒコ | Shimizu Takahiko
Affiliation and department：
National Center for Geriatrics and Gerontology Aging Stress Response Research Project Team

About National Center for Geriatrics and Gerontology Aging Stress Response Research Project Team


Other affiliations (1)：
  • Chiba University Graduate School of Medicine
Research field  (3)： Medical biochemistry ,  Applied biochemistry ,  Nutrition and health science
Research keywords  (8)： Functional food ,  Aging ,  Healthy lifespan ,  Redox regulation ,  Aging stress ,  longevity ,  Reactive oxygen species ,  Oxidative stress
Research theme for competitive and other funds  (27)：
  • 2020 - 2023 Molecular mechanism of osteocyte senescence by mitochondrial retrograde signaling
  • 2017 - 2020 Elucidation of molecular pathology of aging and diseases based on multi-dimensional analysis of progeroid syndromes
  • 2014 - 2019 Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta
  • 2015 - 2018 Establishment of novel therapies for steatohepatitis and liver cancer, by targeting the free cholesterol-mediated signaling pathway.
  • 2014 - 2017 Oxidative stress in bone regulates skeletal homeostasis in mice
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Papers (147)：
  • Naotaka Izuo, Nobuhiro Watanabe, Yoshihiro Noda, Takashi Saito, Takaomi C Saido, Koutaro Yokote, Harumi Hotta, Takahiko Shimizu. Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease. Aging cell. 2023. e13994
  • Takahito Maki, Masahito Sawahata, Ichiro Akutsu, Shohei Amaike, Genki Hiramatsu, Daisuke Uta, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie, Toshiaki Kume. APP knock-in mice produce E22P-Aβ exhibiting an Alzheimer’s disease-like phenotype with dysregulation of hypoxia-inducible factor expression. International Journal of Molecular Sciences. 2022. 23. 21. 13259-13259
  • Aya Shiraki, Jun-ichi Oyama, Takahiko Shimizu, Takayuki Nakajima, Takashi Yokota, Koichi Node. Empagliflozin improves cardiac mitochondrial function and survival through energy regulation in a murine model of heart failure. European Journal of Pharmacology. 2022. 175194-175194
  • Naotaka Izuo, Takahiko Shimizu, Kazuma Murakami, Kazuhiro Irie. Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β. YAKUGAKU ZASSHI. 2021. 141. 6. 843-849
  • Yayoi Obata, Kazuma Murakami, Taiji Kawase, Kenji Hirose, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie. Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer’s Disease. ACS Omega. 2020. 5. 34. 21531-21537
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MISC (7)：
  • 森川 大智, 清水 孝彦, 糸魚川 善昭, 川崎 隆之, 金子 和夫, 佐野 博高, 井樋 栄二, 西條 芳文. 腱板骨付着部変性における酸化ストレスの寄与. 肩関節. 2013. 37. 2. 825-828
  • 川上 哲, 松田 瑛奈, 金子 孝夫, 田原 正一, 白澤 卓二, 清水 孝彦. 抗酸化物質によるmitochondrial cardiomyopathyの予防と治療. 日本抗加齢医学会総会プログラム・抄録集. 2008. 8回. 201-201
  • 佐々木 徹, 酒井 政伸, 清水 孝彦, 白澤 卓二, 田原 正一, 金子 孝夫, 小島 周二. 活性酸素の生成と制御のトポロジーに関する研究. 基礎老化研究. 2008. 32. 2. 38-38
  • 佐々木 徹, 酒井 政伸, 清水 孝彦, 白澤 卓二, 田原 正一, 金子 孝夫, 小島 周二. 細胞内の活性酸素生成部位と量の推定に関する研究. 日本薬学会年会要旨集. 2008. 128年会. 3. 24-24
  • 寺川雄大, 山崎明子, 布村一人, 清水孝彦, 杉野浩幸, 池上晋. Localization change of transglutaminase in Asterina pectinifera embryonic development process. 日本動物学会大会予稿集. 1998. 69th
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Education (3)：
  • Hiroshima University Faculty of Applied Biological Science
  • Hiroshima University Graduate School of Biosphere Science
  • Department of Applied Biochemistry, Hiroshima University
Professional career (1)：
  • Ph.D.
Work history (4)：
  • 2019 - 現在 National Center for Geriatrics and Gerontology
  • 2011 - 2019 Chiba University Graduate School of Medicine
  • 2003 - 2011 Tokyo University of Agriculture and Technology
  • 1997 - 2011 Tokyo Metropolitan Institute of Gerontology
Committee career (7)：
  • 2015 - 現在 The Japan Society for Biomedical Gerontology Directors
  • 2015 - 現在 日本基礎老化学会 理事
  • 2007 - 現在 日本抗加齢医学会 評議員
  • 2007 - 現在 Japanese Society of Anti-Aging Medicine councilor
  • 2015 - 2019 The Japan Society for Biomedical Gerontology Editor in Chief of Editorial Committee
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Association Membership(s) (12)：
日本抗加齢医学会 ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY ,  The American Society for Bone and Mineral Research ,  Japanese Society of Anti-Aging Medicine ,  American Aging Association ,  Society for Neuroscience ,  and Agrochemistry ,  Biotechnology ,  Japan Society for Bioscience ,  The Japanese Biochemical Society ,  JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
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