Morioka Norimitsu

モリオカノリミツ | Morioka Norimitsu

Affiliation and department：
Job title：教授

Research field (1)： Pharmacology

Research keywords (9)： chronic pain , osteoarthritis , trigeminal neuropathy , senescence , mood disorder , microglia , astrocytes , HMGB1 , connexin/gap junction

Research theme for competitive and other funds (20)：

2022 - 2025 ミクログリアの細胞老化現象に着目した認知機能障害の発症・増悪機構の解明と応用
2022 - 2025 慢性疼痛における核内受容体RORsの機能解析と新規治療戦略への応用
2020 - 2023 前帯状皮質ミクログリアに着目した慢性疼痛の病態解明と新規創薬ターゲットの探索
2020 - 2022 In-situ synthesis of bioactive substances in a cell using near-infrared two-photon excitation
2017 - 2020 Role of nuclear receptor REV-ERB in chronic pain and their potential as therapeutic targets for analgesics

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Papers (109)：

Kana Oue, Yosuke Yamawaki, Kazuhisa Ouhara, Eiji Imado, Tetsuya Tamura, Mitsuru Doi, Yoshitaka Shimizu, Mitsuhiro Yoshida, Noriyoshi Mizuno, Norimitsu Morioka, et al. Oral administration of Porphyromonas gingivalis to mice with diet-induced obesity impairs cognitive function associated with microglial activation in the brain. Journal of Oral Microbiology. 2024. 16. 1
Kazue Hisaoka-Nakashima, Yuka Takeuchi, Yukino Saito, Takahisa Shimoda, Yoki Nakamura, Dengli Wang, Keyue Liu, Masahiro Nishibori, Norimitsu Morioka. Glucocorticoids induce HMGB1 release in primary cultured rat cortical microglia. Neuroscience. 2024. 560. 56-66
Norimitsu Morioka, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakata. High mobility group box-1: A therapeutic target for analgesia and associated symptoms in chronic pain. Biochemical Pharmacology. 2024. 222. 116058-116058
Dang, Thu Nguyen, Tien, Son Nguyen, Ochi, Ryosuke, Nishio, Kyo, Kuwamura, Hiroki, Kurose, Tomoyuki, Fujita, Naoto, Nishijo, Hisao, Nakamura, Yoki, Hisaoka-Nakashima, Kazue, et al. Enhanced anxiety-like behavior induced by chronic neuropathic pain and related parvalbumin-positive neurons in male rats. BEHAVIOURAL BRAIN RESEARCH. 2024. 459. 114786-114786
Simeng Ma, Yoki Nakamura, Takahiro Kochi, Suzuna Uemoto, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Norimitsu Morioka. Perineural Treatment with High Mobility Group Box-1 Monoclonal Antibody Prevents Initiation of Pain-Like Behaviors in Female Mice with Trigeminal Neuropathy. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 221-226

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MISC (1)：

Cannabis use disorder and treatment of dependence. Japanese journal of clinical medicine. 2010. 68. 8. 1475-1478

Lectures and oral presentations (117)：

ミクログリアの細胞老化に着目した老化マウスのうつ・不安様症状の解析
(日本薬学会第144年会 2024)
神経障害性疼痛モデルマウスにおける不安・うつ様行動に対するHMGB1中和抗体経鼻投与の効果の検討
(日本薬学会第144年会 2024)
核内受容体 RORγ 阻害薬はミクログリア活性を抑制することで疼痛緩和効果を示す
(日本薬学会第144年会 2024)
ラット初代培養軟骨細胞における機械的刺激による炎症反応の増強作用メカニズムの検討
(日本薬学会第144年会 2024)
三叉神経損傷後の冷刺激過敏化に対するカンナビノイド CB2 アゴニストの効果
(日本薬学会第144年会 2024)

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Education (3)：

1999 - 2002 Hiroshima University Graduate School, Division of Medical Sciences Graduate School, Division of Medical Sciences
1997 - 1999 Hiroshima University Graduate School, Division of Medical Sciences Graduate School, Division of Medical Sciences
1993 - 1997 Hiroshima University Faculty of Medicine Faculty of Medicine

Work history (6)：

2019/04/01 - Hiroshima University Graduate School of Biomedical & Health Sciences Professor
2016/04/01 - 2019/03/31 Hiroshima University Institute of Biomedical & Health Sciences Professor
2013/04/01 - 2016/03/31 Hiroshima University Institute of Biomedical & Health Sciences Associate professor
2009/10/01 - 2013/03/31 Hiroshima University Graduate School of Biomedical & Health Sciences Assistant Professor
2007/04/01 - 2009/09/30 Hiroshima University Graduate School of Biomedical Sciences Research associate

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Association Membership(s) (5)：

日本神経化学会 , 日本疼痛学会 , 日本神経精神薬理学会 , 日本薬理学会 , 日本薬学会

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