Rchr
J-GLOBAL ID：200901075308742235
Update date: Feb. 14, 2024
Nakakuma Hideki
ナカクマ ヒデキ | Nakakuma Hideki
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Affiliation and department：
Wakayama Medical University Faculty of Medicine, Department of Hematology/Oncology
About Wakayama Medical University Faculty of Medicine, Department of Hematology/Oncology
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Detailed information
Job title：
Professor
Research field (1)：
Hematology and oncology
Research keywords (2)：
血液内科学
, Clinical Hematology
Research theme for competitive and other funds (6)：
1978 - 発作性夜間血色素尿症の病因と病態に関する研究
1978 - Study on Etiology and pathogenesis of Paroxysmal Nocturnal Hemoglobinuria
特発性造血障害の分子病態
癌の免疫エスケープ
Pathogenesis of marrow failure syndromes
Immune escape of tumor cells
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Papers (1)：
Nobuyoshi Hanaoka, Yoshiko Murakami, Masahide Nagata, Shoichi Nagakura, Yuji Yonemura, Takashi Sonoki, Taroh Kinoshita, Hideki Nakakuma. Persistently high quality of life conferred by coexisting congenital deficiency of terminal complement C9 in a paroxysmal nocturnal hemoglobinuria patient. BLOOD. 2012. 119. 16. 3866-3868
MISC (135)：
K. Kojima, M. Konopleva, T. Tsao, M. Andreeff, H. Ishida, Y. Shiotsu, L. Jin, Y. Tabe, H. Nakakuma. Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis. LEUKEMIA. 2010. 24. 1. 33-43
Shima Uneda, Minako Gotoh, Takashi Sonoki, Kazuhiro Nishida, Yasushi Nakamura, Miwa Kurimoto, Nobuyoshi Hanaoka, Hiroshi Matsuoka, Masafumi Taniwaki, Hideki Nakakuma. Establishment of CD5 and CD10 double-positive mature B-cell line, WILL1, showing complex 8q24 translocation involving 14q32 and 6q27. INTERNATIONAL JOURNAL OF HEMATOLOGY. 2008. 88. 5. 536-542
Takashi Sonoki, Sonoko Ishihara, Shima Uneda, Nobuyoshi Hanaoka, Miwa Kurimoto, Hiroshi Matsuoka, Hideki Nakakuma. Aggressive CD5-positive B-cell lymphoma after remission of CD5-negative follicular lymphoma with distinct immunoglobulin heavy chain rearrangement and translocation. INTERNATIONAL JOURNAL OF HEMATOLOGY. 2008. 88. 3. 299-303
Kensuke Kojima, Marina Konopleva, Twee Tsao, Hideki Nakakuma, Michael Andreeff. Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia. BLOOD. 2008. 112. 7. 2886-2895
K. Kojima, M. Shimanuki, M. Shikami, I. J. Samudio, V. Ruvolo, P. Corn, N. Hanaoka, M. Konopleva, M. Andreeff, H. Nakakuma. The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML. LEUKEMIA. 2008. 22. 9. 1728-1736
ｍore...
Books (3)：
Non-immue hemoltic anemia
In Conn's Current Therapy 1999
The protein kinase C pathway in tumor promotion. (共著)
"Skin carcinogenesis : Mechanism and Human Relevance" Alan R. Liss 1989
Gene controlled expression of ganglioside . (共著)
"Cellular and Pathological Aspects of Glycoconjugate Metabolism. " Inserm 1984
Education (4)：
- 1986 The University of Tokyo
- 1986 The University of Tokyo Graduate School, Division of Medical Sciences Biochemistry
- 1978 Kumamoto University School of Medicine
- 1978 Kumamoto University Faculty of Medicine Medicine
Professional career (1)：
Doctor (The University of Tokyo)
Work history (5)：
2003 - 2004 Wakayama Medical University
1986 - 2003 Kumamoto University
2003 - - 和歌山県立医科大学
1978 - 1986 The University of Tokyo
1978 - 1986 University of Tokyo
Committee career (2)：
日本臨床腫瘍学会 評議員
日本血液学会 代議員
Awards (4)：
2010/06 - 武田科学振興財団 生命科学研究助成
1998 - 熊本医学会奨励賞
1993 - (財)難病医学研究財団研究奨励
1993 - 日本内科学会奨励賞
Association Membership(s) (4)：
日本臨床腫瘍学会
, 米国血液学会(The American Society of Hematology)
, 日本血液学会
, 日本内科学会
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