Murakumo Yoshiki

ムラクモヨシキ | Murakumo Yoshiki

Affiliation and department：
Job title：教授

Research field (2)： Experimental pathology , Molecular biology

Research keywords (6)：分子生物学・発癌・DNA修復・突然変異・細胞周期調節 , cell cycle control , mutagenesis , DNA repair , carcinogenesis , molecular biology

Research theme for competitive and other funds (27)：

2023 - 2026 胸腺腫発症ラットの原因遺伝子変異導入マウスを用いたヒトB型胸腺腫の病態解明
2021 - 2024 DNA損傷トレランスタンパク質REV7を介した紫外線誘発皮膚癌の発生機序の解明
2021 - 2024 術前化学療法進行胃癌に対する治療効果とDNA修復関連蛋白REV7の発現との関連
2020 - 2023 Biomarkers for predicting response to immune checkpoint inhibitor therapy in malignant melanoma.
2018 - 2021 Elucidation of novel molecular mechanisms for maintenance of spermatogonial stem cells and gametogenesis in the testis

2017 - 2020 REV expression as a biomarker for head and neck cancer

2015 - 2018 Identification and functional analysis of causative genes for thymoma and muscle atrophy developing in BUF/Mna rats

2015 - 2018 Involvement of translesion DNA synthesis in the development of UV-induced skin cancer and its possible mechanisms

2014 - 2017 Proteomic analysis of bile

2012 - 2016 Molecular hydrogen attenuates UV-induced tissue injury in Caenorhabditis elegans and mouse

2012 - 2015 Significance of REV7 for germ cell maintenance and spermatogenesis

2012 - 2014 Mechanism of chemoresistance by HDAC1-associating protein and development of molecular targeted therapy

2011 - 2014 Molecular mechanisms of postnatal angiogenesis and neurogenesis

2009 - 2011 Analyses of biological significance of GPI-anchored protein CD109 in mouse development

2008 - 2010 Identification of downstream regulatory factor in RET signaling pathway and its application to cancer treatment

2008 - 2010 New approach for health maintenanceand disease control by modification of inhaled air composition

2007 - 2008 GPIアンカー型膜蛋白CD109を標的とした扁平上皮癌に対する新規診断法の開発

2007 - 2008 Involvement of DNA repair protein REV7 in cell proliferation, mobility and organogenesis

2006 - 2007 Sprouty family of proteins regulates organogenesis and carcinogenesis through the signaling caused by RET tyrosine kinase

2005 - 2006 Generation and Characterization of Knockout Mice Targeting REV7 gene, which is involved in DNA damage tolerance

2003 - 2006 In vivo role of the GDNF/RET signaling pathway in morphogenesis and pathogenesis

2002 - 2003 Characterization of human REV proteins which are involved in mutagenesis

2002 - 2003 Glial Cell line-derived neurotrophic factor (GDNF) inducible genes regulate neuronal differentiation and kidney development

1996 - DNA損傷と発癌

1996 - DNA damage and carcinogenesis

DNA修復と突然変異

DNA repair and mutagenesis

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Papers (145)：

Akihiro Tamaki, Takuya Kato, Yasutaka Sakurai, Keita Sato, Kai Adachi, Masayoshi Tadehara, Taro Kogami, Masahiro Matsushita, Akiyoshi Hoshino, Itaru Sanoyama, et al. REV7 is involved in outcomes of platinum-based chemotherapy in pancreatic cancer by controlling the DNA damage response. Cancer science. 2024. 115. 2. 660-671
Kazu Shiomi, Masaaki Ichinoe, Ai Ushiwata, Koji Eshima, Ryo Nagashio, Shoko Hayashi, Dai Sonoda, Yasuto Kondo, Raito Maruyama, Masashi Mikubo, et al. Insight into the significance of CD8+ tumor-infiltrating lymphocytes in squamous cell lung cancer. Thoracic Cancer. 2023
Yuko Shimada, Takuya Kato, Yasutaka Sakurai, Hitoe Watanabe, Mayu Nonaka, Natsumi Nanaura, Masaaki Ichinoe, Yoshiki Murakumo. Identification of the promoter region regulating the transcription of the REV7 gene. Biochemical and biophysical research communications. 2023. 662. 8-17
Yoshiki Murakumo, Yasutaka Sakurai, Takuya Kato, Hiroshi Hashimoto, Masaaki Ichinoe. REV7 in Cancer Biology and Management. Cancers. 2023. 15. 6
Shotaro Tatekawa, Keisuke Tamari, Ryota Chijimatsu, Masamitsu Konno, Daisuke Motooka, Suguru Mitsufuji, Hirofumi Akita, Shogo Kobayashi, Yoshiki Murakumo, Yuichiro Doki, et al. N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma. Scientific Reports. 2022. 12. 1

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MISC (140)：

山下和也, 佐藤雄一, 久場樹, 吉田佐土子, 横澤正志, 村雲芳樹. 細胞株を用いた免疫組織化学染色マルチプルコントロール試料の作製と標準化の基礎的検討. 神奈川県臨床検査技師会雑誌 = The Kanagawa journal of medical technology. 2016. 51. 168. 44-53
Yoshiki Murakumo, Naoki Watanabe, Shinji Mii, Masato Asai, Naoya Asai, Kaoru Niimi, Takuya Kato, Atsushi Enomoto, Masahide Takahashi. DNA repair protein Rev7 is required for primordial germ cell maintenance in the mouse. CANCER RESEARCH. 2014. 74. 19
Sumitaka Hagiwara, Noriyuki Yamamoto, Hiroki Furue, Hiroki Sakakura, Toshio Shigetomi, Yoshiki Murakumo, Hideharu Hibi, Masahide Takahashi, Minoru Ueda. Pathological analysis of Ki-67 and CD109 expression in tongue squamous cell carcinoma. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2013. 25. 3. 276-281
Shinji Mii, Yoshiki Murakumo, Naoya Asai, Masato Asai, Masahide Takahashi. Deficiency of CD109, a negative regulator of TGF-beta signaling, leads epidermal hyperplasia and appendage abnormalities in mice. CANCER RESEARCH. 2012. 72
Yoshiki Murakumo, Masahide Takahashi. Glycosylation-dependent effect of CD109 on TGF-beta1 and EGF signaling in human glioblastoma cells. CANCER RESEARCH. 2012. 72

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Books (1)：

RETチロシンキナーゼの生理機能
ニューサイエンス社 2008

Works (9)：

扁平上皮癌特異的高発現を示す蛋白CD109の腫瘍マーカーとしての有用性の検討
2009 - 2009
癌・精巣抗原CD109の肺扁平上皮癌発生によける役割の解明と血清診断・分子標的癌治療への応用
2009 -
DNA損傷応答に関わる蛋白REV7の細胞増殖・運動と個体発生における重要性の検討
2007 - 2008
RETチロシンキナーゼの下流シグナルを調節する因子の探索と発癌制御への応用
2008 -
生活環境における吸入気体組成の調節に基づく健康維持と疾患制御の試み
2008 -

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Education (4)：

- 1995 Nagoya University
- 1995 Nagoya University Graduate School, Division of Medicine Depertment of Pathology
- 1988 Nara Medical University
- 1988 Nara Medical University Devision of Medicine

Professional career (1)：

Doctor of Medicine (Nagoya University)

Work history (9)：

2006 - 2012 - 名古屋大学大学院医学系研究科病理病態学講座准教授
2002 - 2006 名古屋大学大学院医学系研究科病理病態学講座講師
2000 - 2002 名古屋大学大学院医学系研究科病理病態学講座助手
2000 - 2002 Assistant Professor, Department of Pathology, Nagoya University Graduate School of Medicine
1995 - 1996 名古屋記念病院腫瘍科医師

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Committee career (1)：

2001 - 日本病理学会評議員

Association Membership(s) (8)：

日本臨床細胞学会 , 日本病理学会 , 日本癌学会 , アメリカ癌学会 , Japanese Society of Clinical Cytology , Japanese Sociaty of Pathology , Japanese Cancer Association , American Association for Cancer Research

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