Rchr
J-GLOBAL ID:200901075692782648
Update date: Feb. 01, 2024
Hiromi Sakai
サカイ ヒロミ | Hiromi Sakai
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www.naramed-u.ac.jp/~chem/
Research field (2):
Biomaterials
, Nanobioscience
Research keywords (15):
Gas Biology
, Resuscitation
, Artificial Oxygen Carriers
, transfusion alternative
, Biomaterials
, Artificial Organs
, Microcirculation
, Hemorheology
, Oxygen Transport to Tissues
, Drug Delivery System
, Liposomes
, Redox of Heme Proteins
, Hemoglobin
, Blood Substitutes
, Artificial Red Cells
Research theme for competitive and other funds (32):
- 2022 - 2025 ヘモグロビンを基盤とした次世代型高感度ナノMRI造影剤の開発
- 2022 - 2025 Suppressed methemoglobin formation of artificial red cell by liposomal antioxidants and its mechanism.
- 2022 - 2025 Use of Hemoglobin Vesicles during Cardiopulmonary Bypass Priming Prevents Organ Dysfunction
- 2021 - 2024 Starburst hemoglobin polymer with controlled physical properties as a red blood cell substitute
- 2021 - 2024 切断四肢保存のための人工赤血球灌流療法の開発
- 2021 - 2024 ナノDDSを応用した腎毒性を低減できる新規ヨード造影剤の開発と体内動態の解明
- 2021 - 2024 備蓄・緊急投与が可能な人工赤血球製剤の実用化を目指す研究
- 2021 - 2024 Resuscitation from hemorrhagic shock by carbon monoxide- and oxygen-carrying capacities of artificial red cells.
- 2019 - 2022 Search into the mechanism of B7-H3 expressing MDSC generation by liposome and its T cell suppression
- 2018 - 2021 人工血液カクテルによる次世代保育器の開発
- 2018 - 2021 備蓄・緊急投与が可能な人工赤血球製剤の臨床への橋渡し研究
- 2017 - 2020 Application of artificial oxygen-carrying hemoglobin vesicles for marginal liver grafts in machine perfusion preservation
- 2017 - 2020 Synthesis and in vivo characterization of polymer-multilinked hemoglobin assembly as artificial oxygen carrier
- 2016 - 2020 Mechanism of B7-H3 expression on liposome induced MDSC-like cell and its influence on immunosuppression
- 2015 - 2020 Effects of HbV during Apnea situation
- 2017 - 2020 酸化ストレスに対する防御機能を有する人工赤血球製剤の創製と体内評価
- 2016 - 2019 Combination therapy using fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage
- 2016 - 2019 Reducing ischemic lung perfusion injury by artificial hemoglobin
- 2015 - 2018 備蓄・緊急投与が可能な人工赤血球製剤の実用化を目指す研究
- 2013 - 2017 Detection of molecules involved in the induction of immunosuppressive function of MDSC-like cells induced by liposome
- 2013 - 2016 Effect of oxygen infusion with hemoglobin vesicles on respiratory insufficiency
- 2013 - 2016 人工赤血球の酸素運搬機能時間を体内電子供与系の活用により飛躍的に延長させる
- 2012 - 2015 Development of a novel therapy for fetal hypoxia used by artificial oxygen carriers (hemoglobin vesicles)
- 2012 - 2015 人工赤血球(ヘモグロビン小胞体)の実用化を目指す研究
- 2012 - 2014 Development of an adjuvant therapy for severe malaria with the hemoglobin vesicle, an artificial oxygen carrier.
- 2012 - 2014 Microhemodynamic properties and gas reactions of abnormal RBCs in narrow tubes
- 2010 - 2012 Application of hemoglobin vesicles for lung transplantation
- 2010 - 2012 Bioengineering of artificial red cells for clinical application
- 2007 - 2009 Artificial Red Cells : Physiological Importance of the Ligand Reaction Dynamism and the New Application for Ligand Therapy
- 2004 - 2006 "Analysis of oxygen releasing behavior of hemoglobin-vesicles (nano-particles) and the mechanism of oxygenation of ischemic tissue."
- 2000 - 2002 Microhemodynamics after Infusion of an Artificial O_2 Carriers Using Laser Flash Irradiation.
- 2000 - 2001 Establishment of production process of cellular- type oxygen carriers
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Papers (319):
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Hiromi Sakai, Tomoko Kure, Naoko Kobayashi, Tadashi Ito, Yasushi Yamada, Tetsuya Yamada, Rina Miyamoto, Takahito Imaizumi, Jiro Ando, Takaomi Soga, et al. Absence of Anaphylactic Reactions to Injection of Hemoglobin Vesicles (Artificial Red Cells) to Rodents. ACS Omega. 2023
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Yuto Suzuki, Yo Arakida, Hiromi Sakai, Yuki Enoki, Kazuaki Matsumoto, Kazuaki Taguchi. Elucidating the binding properties of methemoglobin in red blood cell to cyanide, hydrosulfide, and azide ions using artificial red blood cell. Toxicology and Applied Pharmacology. 2023. 116752-116752
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Taisei Nagasaki, Hitoshi Maeda, Hiroki Yanagisawa, Kento Nishida, Kazuki Kobayashi, Naoki Wada, Isamu Noguchi, Ryotaro Iwakiri, Kazuaki Taguchi, Hiromi Sakai, et al. Carbon Monoxide-Loaded Red Blood Cell Prevents the Onset of Cisplatin-Induced Acute Kidney Injury. Antioxidants. 2023. 12. 9. 1705-1705
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Nur Khatijah Mohd Zin, Hiroki Bochimoto, Daisuke Kondoh, Yo Ishihara, Hiroyoshi Iwata, Tatsuya Shonaka, Hiromichi Obara, Hiromi Sakai, Hiroyuki Furukawa, Naoto Matsuno. Machine perfusion preservation with hemoglobin based oxygen vesicles alleviate ultrastructural damages in porcine liver donated after cardiac death. Microscopy Research and Technique. 2023
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宏水 酒井, 直子 小林, 智子 久禮, 寛 東. “人工赤血球”の外科・代謝栄養学への応用の可能性. The Japanese Journal of SURGICAL METABOLISM and NUTRITION. 2023. 57. 4. 100-103
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MISC (43):
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ヘモグロビンとPEGが結合した巨大な環状モノマーの開環重合. ヘモグロビンとPEGが結合した巨大な環状モノマーの開環重合. 化学と工業. 2023. 76. 4. 261-261
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Okuda C, Sakai H. ヘモグロビン-ベシクルを用いた一酸化炭素投与が海馬組織に与える影響(論文紹介). 医療ガス情報ファイル. 2023. 21. 26-27
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東寛, 酒井宏水. 人工赤血球製剤ヘモグロビンベシクルの臨床第一相試験. 日本輸血・細胞治療学会e-News. 2023. 21. 5-7
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酒井宏水. 鉄に依存した赤血球の酸素輸送機能と人工赤血球. 生環境構築史 第3号特集:鉄の惑星・地球. 2021
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酒井 宏水, 久禮 智子, 小林 直子, 松本 雅則, 杉田 修, 神山 直也, 竹原 有史, 東 寛. 備蓄・緊急投与が可能な人工赤血球製剤の開発状況 人工赤血球(ヘモグロビンベシクル)製剤の治験薬GMP製造. 人工血液. 2021. 29. 1. 12-12
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Patents (8):
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血管を治療標的とするレーザー照射療法用光増感剤
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抗酸化性組成物
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メトヘモグロビン小胞体を有効成分として含む医薬およびその使用
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ヘモグロビンのメト化抑制能を有する人工赤血球
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Production method of vesicles
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Books (33):
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(Chapter 22) Potential Clinical Application of Hemoglobin Vesicles as an Artificial Oxygen Carrier and Carbon Monoxide Carrier. In: "Blood Substitutes and Oxygen Therapeutics", Eds by H. Liu, A.D. Kaye, & J.S. Jahr. Springer
Springer 2022
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Nanobiotherapeutic Based Blood Substitutes
World Scientific Publishing Co. Pte. Ltd. 2021
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生体内移動論, Fournier, R.L.(著)
朝倉書店 2021
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ハーパー・生化学 (原書30版) (翻訳, 清水孝雄 監修)
丸善 2016
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(第6章) 人工赤血球による生体組織への酸素輸送. 「全人力・科学力・透析力に基づく透析医学」平方秀樹 監修
医薬ジャーナル社 2014
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Lectures and oral presentations (140):
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備蓄・緊急投与が可能な 人工赤血球製剤の実用化を目指す研究
(第30回 日本血液代替物学会 年次大会 2023)
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備蓄・緊急投与が可能な 人工赤血球製剤の第一相試験結果と今後の展望
(第51回 日本救急医学会総会・学術集会 2023)
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備蓄・緊急投与が可能な 人工赤血球製剤の実用化を目指す研究
(第3回Challenge万博「いのち輝く未来社会へ」 2023)
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救命領域での利用が期待される人工赤血球製剤の特徴
(第61回 日本人工臓器学会大会 2023)
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備蓄・緊急投与が可能な人工赤血球製剤の治験薬GMP製造とPhase1試験
(第45回 日本バイオマテリアル学会大会 2023)
more...
Education (3):
- - 2006 慶應義塾大学大学院 医学研究科
- 1989 - 1994 Waseda University Graduate School, Division of Science and Engineering Polymer Chemistry
- 1985 - 1989 Waseda University Faculty of Science and Engineering Department of Applied Chemistry
Professional career (2):
- PhD(D.Eng) (Waseda University)
- PhD(D.Med.Sci.) (Keio University)
Work history (12):
- 2013/04 - 現在 Nara Medical University Department of Chemistry Professor
- 2013/04/01 - 2014/03/31 早稲田大学 重点領域研究機構 客員上級研究員(研究院客員教授)
- 2012/04/01 - 2013/03/31 Waseda University Organization for University Research Initiatives Senior Researcher (Professor)
- 2009/09/15 - 2013/03/31 Waseada Bioscience Research Institute in Singapore Principal Investigator
- 2011/10/01 - 2012/03/31 Waseda University Organization for University Research Initiatives Principal researcher (Associate Professor)
- 2002/04/01 - 2012/03/31 Keio University Center for Integrated Medical Research Visiting lecturer, Visiting Associate Professor
- 2007/04/01 - 2010/03/31 Waseda University Research Institute for Science and Engineering Associate Professor
- 2003/10/01 - 2007/03/31 Waseda University Advanced Research Institute for Science and Engineering Associate Professor
- 1999/04/01 - 2003/09/30 Waseda University Advanced Research Institute for Science and Engineering Lecturer
- 1994/04/01 - 1999/03/31 Waseda University Advanced Research Institute for Science and Engineering Researcher
- 1996/06/01 - 1998/04 Japan Society for the Promotion of Science (JSPS), Overseas Research Fellow (Depts. of Bioengineering and Medicine, University of California, San Diego 海外特別研究員(カリフォルニア大学サンディエゴ校 バイオエンジニアリング部門、医学部)
- 1994/04/01 - 1996/05/31 Japan Society for the Promotion of Science (JSPS) Research fellow
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Committee career (13):
- 2019/01 - 2019/11 第17回 国際血液代替物学会(17th-ISBS-2019) Co-president
- 2017 - 2018/07 日本学術振興会 特別研究員等審査会専門委員、卓越研究員候補者選考委員会書面審査委員、国際事業委員会書面審査員・書面評価員
- 2018/04/01 - 日本血液代替物学会 会長
- 2014/02 - 2016 日本人工臓器学会 情報・公報委員会委員
- 2005 - 2016 日本人工臓器学会 評議員
- 2015/04 - 2015/06 International Society for Artificial Cells, Blood Substitutes, and Immobilization Biotechnology ISBS 2015 Scientific advisory board member
- 2013/02 - 2014/02 日本血液代替物学会 第20回年次大会 大会長
- 2013 - 2014 科学研究費委員会 専門委員
- 2010 - 2011 International Society for Oxygen Transport to Tissues (ISOTT) Executive Committee Member
- 2009 - International Society for Artificial Cells, Blood Substitutes, and Immobilization Biotechnology Scientific Advisory Board Member
- 2008 - 日本血液代替物学会 編集委員長
- 2008 - 日本血液代替物学会 理事
- 2004 - 日本血液代替物学会 編集委員
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Awards (4):
- 2008/11 - 向 科学技術振興財団 創立10周年記念 優秀研究
- 2006/12 - Young Investigator Award of the International Liposome Society (London)
- 2003/10 - 平成15年度JSAO-Grant Yoshimi賞 (日本人工臓器学会)
- 1994/03 - 水野記念学術賞(早稲田大学)
Association Membership(s) (12):
日本医工学治療学会
, 日本輸血細胞治療学会
, 日本微小循環学会
, 日本バイオレオロジー学会
, International Society for Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
, International Society for Oxygen Transport to Tissues (ISOTT)
, アメリカ生理学会
, American Chemical Society
, 日本人工臓器学会
, 高分子学会
, 日本化学会
, 日本血液代替物学会
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