Rchr
J-GLOBAL ID:200901075692782648   Update date: Aug. 31, 2021

Hiromi Sakai

サカイ ヒロミ | Hiromi Sakai
Affiliation and department:
Job title: Professor
Homepage URL  (1): http://www.naramed-u.ac.jp/~chem/
Research field  (3): Nanobioscience ,  Biomaterials ,  Biomedical engineering
Research keywords  (15): Gas Biology ,  Resuscitation ,  Artificial Oxygen Carriers ,  transfusion alternative ,  Biomaterials ,  Artificial Organs ,  Microcirculation ,  Hemorheology ,  Oxygen Transport to Tissues ,  Drug Delivery System ,  Liposomes ,  Redox of Heme Proteins ,  Hemoglobin ,  Blood Substitutes ,  Artificial Red Cells
Research theme for competitive and other funds  (6):
  • 2021 - 2024 備蓄・緊急投与が可能な人工赤血球製剤の実用化を目指す研究
  • 2018 - 2021 備蓄・緊急投与が可能な人工赤血球製剤の臨床への橋渡し研究
  • 2017 - 2020 酸化ストレスに対する防御機能を有する人工赤血球製剤の創製と体内評価
  • 2015 - 2018 備蓄・緊急投与が可能な人工赤血球製剤の実用化を目指す研究
  • 2013 - 2016 人工赤血球の酸素運搬機能時間を体内電子供与系の活用により飛躍的に延長させる
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Papers (243):
  • Yuto Suzuki, Kazuaki Taguchi, Tomoko Kure, Hiromi Sakai, Yuki Enoki, Masaki Otagiri, Kazuaki Matsumoto. Liposome-encapsulated methemoglobin as an antidote against cyanide poisoning. Journal of Controlled Release. 2021. 337. 59-70
  • Bonpei Takase, Yuko Higashimura, Haruka Asahina, Masayuki Ishihara, Hiromi Sakai. Liposome-encapsulated hemoglobin (HbV) transfusion rescues rats undergoing progressive lethal 85% hemorrhage as a result of an anti-arrhythmogenic effect on the myocardium. Artificial Organs. 2021
  • Tomoko Kure, Hiromi Sakai. Preparation of Artificial Red Blood Cells (Hemoglobin Vesicles) Using the Rotation-Revolution Mixer for High Encapsulation Efficiency. ACS Biomaterials Science & Engineering. 2021. 7. 6. 2835-2844
  • Takashi Matsuhira, Hiromi Sakai. Entropy-Driven Supramolecular Ring-Opening Polymerization of a Cyclic Hemoglobin Monomer for Constructing a Hemoglobin-PEG Alternating Polymer with Structural Regularity. Biomacromolecules. 2021. 22. 5. 1944-1954
  • Kae Shimanouchi, Naoaki Rikihisa, Yoshiaki Saito, Kaito Iuchi, Norimichi Tsumura, Hiromi Sakai, Nobuyuki Mitsukawa. Artificial red blood cells increase large vessel wall damage and decrease surrounding dermal tissue damage in a rabbit auricle model after subsequent flashlamp-pumped pulsed-dye laser treatment. The Journal of Dermatology. 2021. 48. 5. 600-612
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MISC (14):
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Patents (6):
  • 抗酸化性組成物
  • ヘモグロビンのメト化抑制能を有する人工赤血球
  • Production method of vesicles
  • 配位子置換型輸液製剤
  • メト化防止剤を含有する人工酸素運搬体
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Books (32):
  • Nanobiotherapeutic Based Blood Substitutes
    World Scientific Publishing Co. Pte. Ltd. 2021
  • 生体内移動論, Fournier, R.L.(著)
    朝倉書店 2021
  • ハーパー・生化学 (原書30版) (翻訳, 清水孝雄 監修)
    丸善 2016
  • (第6章) 人工赤血球による生体組織への酸素輸送. 「全人力・科学力・透析力に基づく透析医学」平方秀樹 監修
    医薬ジャーナル社 2014
  • (Chapter 12) Cellular-Type Hemoglobin-Based Oxygen Carriers to Mimic the Red Blood Cell Structure, In: Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics (Editors, Hae Won Kim・A. Gerson Greenburg)
    Springer 2013
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Lectures and oral presentations  (116):
  • Artificial Red Cells Project in Japan (presidential lecture)
    (The 17th International Symposium on Blood Substitutes & Oxygen Therapeutics (XVII-ISBS-2019) 2019)
  • Electron mediators shuttling between erythrocytes and liposomes encapsulating hemoglobin (artificial red cells) to reduce methemoglobin by using abundant glycolytic electron energies
    (American Chemical Society Fall 2019 National Meeting & Exposition 2019)
  • 備蓄・緊急投与が可能な人工赤血球製剤
    (第34回 日本Shock学会総会 2019)
  • Translational Research of Artificial Red Cells for a Transfusion Alternative and O2/CO Therapeutics
    (6th World Congress on Nanomedical Sciences (ISNSCON 2018) 2019)
  • 人工赤血球(ヘモグロビンベシクル)の医療応用
    (MBTオープンミーティング2018 in 東京 2018)
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Education (3):
  • - 2006 慶應義塾大学大学院
  • 1989 - 1994 Waseda University Polymer Chemistry
  • 1985 - 1989 Waseda University Department of Applied Chemistry
Professional career (2):
  • PhD(D.Eng) (Waseda University)
  • PhD(D.Med.Sci.) (Keio University)
Work history (12):
  • 2013/04 - 現在 Nara Medical University Department of Chemistry Professor
  • 2013/04/01 - 2014/03/31 早稲田大学 重点領域研究機構 客員上級研究員(研究院客員教授)
  • 2012/04/01 - 2013/03/31 Waseda University Organization for University Research Initiatives Senior Researcher (Professor)
  • 2009/09/15 - 2013/03/31 Waseada Bioscience Research Institute in Singapore Principal Investigator
  • 2011/10/01 - 2012/03/31 Waseda University Organization for University Research Initiatives Principal researcher (Associate Professor)
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Committee career (12):
  • 2019/01 - 2019/11 第17回 国際血液代替物学会(17th-ISBS-2019) Co-president
  • 2018/04/01 - 日本血液代替物学会 会長
  • 2014/02 - 2016 日本人工臓器学会 情報・公報委員会委員
  • 2005 - 2016 日本人工臓器学会 評議員
  • 2015/04 - 2015/06 International Society for Artificial Cells, Blood Substitutes, and Immobilization Biotechnology ISBS 2015 Scientific advisory board member
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Awards (4):
  • 2008/11 - 向 科学技術振興財団 創立10周年記念 優秀研究
  • 2006/12 - Young Investigator Award of the International Liposome Society (London)
  • 2003/10 - 平成15年度JSAO-Grant Yoshimi賞 (日本人工臓器学会)
  • 1994/03 - 水野記念学術賞(早稲田大学)
Association Membership(s) (12):
日本医工学治療学会 ,  日本輸血細胞治療学会 ,  日本微小循環学会 ,  日本バイオレオロジー学会 ,  International Society for Artificial Cells, Blood Substitutes, and Immobilization Biotechnology ,  International Society for Oxygen Transport to Tissues (ISOTT) ,  アメリカ生理学会 ,  American Chemical Society ,  日本人工臓器学会 ,  高分子学会 ,  日本化学会 ,  日本血液代替物学会
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