Rchr
J-GLOBAL ID:200901075715321813   Update date: Feb. 18, 2019

TOMODA Hiroshi

トモダ ヒロシ | TOMODA Hiroshi
Affiliation and department:
Job title: Professor
Research field  (3): Biomolecular science ,  Chemical pharmacy ,  Biological pharmacy
Research keywords  (3): Microbial natural products chemistry ,  Lipid biochemistry ,  Bioorganic chemistry
Research theme for competitive and other funds  (5):
  • 1983 - Screen for lipid metabolism inhibitors and their biomedical application
  • 2002 - 2006 Screen for anti-infective drugs and their biomedical application
  • Development of anti-atherosclerotic agents
  • Discovery of anti-infective drugs from microorganisms
  • Discovery of drugs useful for life-style related diseases
Papers (172):
  • Uchida R, Kondo A, Yagi A, Nonaka K, Masuma R, Kobayashi K, Tomoda H. Simpotentin, a new potentiator of amphotericin B activity against Candida albicans, produced by Simplicillium minatense FKI-4981. The Journal of antibiotics. 2018. 72. 3. 134-140
  • Ohshiro T, Seki R, Fukuda T, Uchida R, Tomoda H. Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307. The Journal of antibiotics. 2018. 71. 12. 1000-1007
  • Fukuda T, Furukawa T, Kobayashi K, Nagai K, Uchida R, Tomoda H. Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142. The Journal of antibiotics. 2018. 72. 1. 8-14
  • Koyama N, Tomoda H. MS network-based screening for new antibiotics discovery. The Journal of antibiotics. 2018. 72. 1. 54-56
  • Kobayashi K, Ohte S, Ohshiro T, Ugaki N, Tomoda H. A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction. Scientific reports. 2018. 8. 1. 12099
more...
MISC (136):
Books (3):
  • Fatty acid synthetase from <DB>Cephalosporium(/)-</DB> <DB>caerulens(/)-</DB>
    Methods in Enzymology 1981
  • Screening for inhibitors of lipid metabolism
    Enzyme Technology for Pharmaceutical and Biotechnological Applications(Marcel Dekker Inc.) 2001
  • “Discovery of lead compounds for medicines from microorganisms”. <i>Biotechnology in the 21st Century</i>
    Indonesia Biotechnology Consortium 2002
Lectures and oral presentations  (25):
  • Mass spectral library of microbial metabolomes for screening of antibiotics.
    (International Union of Microbiological 2017)
  • SOAT2 選択的阻害剤は脂肪性肝疾患に有効か?
    (第59回 日本脂質生化学会 2017)
  • MSネットワークアプローチが切り開く微生物資源からの新たな探索研究
    (第2回低・中分子創薬推進プラットフォーム 2017)
  • 軸異性を有する真菌由来化合物ダイナピノンが示す脂肪滴分解促進活性 の作用機序解析
    (第59回 日本脂質生化学会 2017)
  • MSネットワーク手法を利用した Mycobacterium avium complex に対する新規抗菌物質の探索研究
    (第32回日本放線菌学会大会 2017)
more...
Works (3):
  • Screening for lipid metabolism inhibitors
    1989 - 1996
  • Screen for transcriptional regulators of microbial origin
    1993 -
  • Discovery and production of lead compounds for medicines from microorganisms
    1996 - 2000
Education (2):
  • - 1978 The University of Tokyo Faculty of Pharmaceutical Science
  • - 1983 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
Professional career (1):
  • Ph.D. (The University of Tokyo)
Work history (5):
  • 1987 - 1989 Postdoctoral fellow, The Johns Hopkins University
  • 1983 - 1990 Researcher, The Kitasato Institute
  • 1990 - 1996 Chief researcher, The Kitasato Institute
  • 1996 - 2001 Associate director, The Kitasato Institute
  • 2001 - Professor Kitasato University
Association Membership(s) (1):
Society for Industrial Microbiology
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