Rchr
J-GLOBAL ID:200901075757507232
Update date: Apr. 11, 2024
Onodera Osamu
Onodera Osamu | Onodera Osamu
Affiliation and department:
Job title:
所長・教授
Homepage URL (1):
https://scholar.google.co.jp/citations?hl=ja&user=GlabWvwAAAAJ&view_op=list_works
Research field (4):
Radiology
, Neurology
, Neuroanatomy and physiology
, Human pathology
Research keywords (36):
脊髄小脳変性症
, 神経変性疾患
, 神経病態
, スプライシング
, 筋萎縮性側索硬化症
, 多系統萎縮症
, 核内小体
, アプラタキシン
, 脳小血管
, 封入体
, ポリグルタミン
, DNA修復
, グリア
, TGF-β
, DNA損傷修復
, CAG繰り返し配列
, マイクロアレイ
, 炎症
, 血管性認知症
, HTRA1
, 包括脳ネットワーク
, TDP-43
, ALS
, XRCC1
, DRPLA
, aggresome
, Huntington disease
, MTOC
, UPS
, polygultamine
, GFP
, unfolding protein
, intermediate filaments
, 天然変性蛋白
, CREB依存性転写
, Molecular neurobiology
Research theme for competitive and other funds (55):
- 2022 - 2025 脳小血管の細胞外基質の摂動を起こす細胞群の同定と、その制御機構の解読
- 2019 - 2023 脊髄運動ニューロン固有のRNA制御プログラムとALS病態の関連
- 2019 - 2022 Approach to neurodegenerative disorders by elucidation of the excretion pathway of the brain.
- 2017 - 2020 Tauopathy affecting astrocytes: diversity in the tau pathology and the astrocytic molecular feature
- 2018 - 2020 成人発症白質脳症の実際と有効な医療施策に関する研究班
- 2016 - 2019 Strategies for overcoming vascular dementia focusing on dynamic functions of cerebral small vessels.
- 2015 - 2019 Brain Protein Aging and Dementia Control(International Research Activities Supporting Program)
- 2014 - 2019 Mechanism of protein aging from the point of turbulence of nucleic acid metabolism or its exclusion mechanism.
- 2017 - 2019 TGF-βシグナルを標的にしたCARASILの新規治療シーズの探索
- 2017 - 2019 ゲノム編集を用いた優性遺伝性中枢神経疾患の治療方法の開発
- 2017 - 2019 ポリグルタミン病に対する蛋白質凝集阻害薬の開発(大阪大学B-49)
- 2016 - 2018 重合体形成阻害を標的としたポリグルタミン病の新規治療法開発
- 2016 - 2018 Elucidation of the significance of MAPT polymorphism associated with sporadic tauopathies by using genome editing method.
- 2015 - 2018 Crosstalk between stress granules and autophagy in protein degradation
- 2014 - 2017 Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning
- 2016 - 2017 成人発症白質脳症の医療基盤に関する調査研究班
- 2014 - 2016 Heterogeneity of TDP-43 pathology and clinicopathologic correlations in sporadic amyotrophic lateral sclerosis
- 2013 - 2016 Establishment of TDP-43 C-terminal deficient mice using zinc finger nuclease and application to the model for amyotrophic lateral sclerosis
- 2013 - 2016 Approach to cerebral small vessel disease: lesson from CARASIL.
- 2013 - 2016 Identification of splicing factors that bind to expanded GGGGCC repeat and TDP-43 mRNA
- 2013 - 2016 Autoreguation of TDP-43 in ALS
- 2013 - 2016 Developing new therapeutic drugs that inhibit oligomer formation of polyglutamine disease proteins based on the hypothesis of oligomer toxicity in polyglutamine diseases
- 2013 - 2015 U12依存性スプライシングとALSサーキットパソロジー
- 2015 - 2015 新規臨床評価方法によるフォールディング病の化学シャペロンでの病態抑制効果の検討
- 2011 - 2014 ALS and TDP-43: Dose the splicing failure underlie the pathogenesis of ALS?
- 2013 - 2013 遺伝性脳小血管病およびその類縁疾患の診断基準の確立と治療法の研究
- 2012 - 2013 遺伝性脳小血管病およびその類縁疾患の診断基準の確立と治療法の研究
- 2010 - 2013 Molecular pathogenesis of cerebral small vessel disease.
- 2011 - 2012 細胞内膜構造に注目した運動神経病の画期的な治療法の開発
- 2011 - 2012 An immunohistochemical study on nuclear bodies in neurodegenerativediseases with abnormal protein aggregates
- 2010 - 2012 細胞内膜構造に注目した運動神経病の画期的な治療法の開発
- 2010 - 2012 Mathematic statistical analyses of relationship between severity of neurological symptom and MRI measurements of white matter injury
- 2010 - 2012 Molecular pathogenesis of ALS: approach from TDP-43 function.
- 2010 - 2012 Analysis of TDP-43 functions and modeling for ALS using conditional knockout mice
- 2011 - 2011 遺伝性脳小血管病の病態機序の解明と治療法の開発
- 2010 - 2011 遺伝性脳小血管病の病態機序の解明と治療法の開発
- 2010 - 2011 Identification for serum biomarker for ALS associated with the function of TDP-43
- 2010 - 2011 天然変性タンパク質の機能解析によるALSの病態機序の解明
- 2008 - 2010 L-plastin ; the possibility as a surrogate marker of polyglutamine diseases.
- 2008 - 2010 Amyotrophic lateral sclerosis and TDP-43 : elucidation of the entire neuropathological picture and molecular pathomechanism
- 2009 - 2009 遺伝性脳小血管病の病態機序の解明と治療法の開発
- 2008 - 2009 核内小体機能不全による非翻訳リボ核酸の異常による運動神経細胞死の研究
- 2007 - 2009 Impairment of quality control system for nucleic acids and neurodegenerative disorders.
- 2005 - 2009 Elucidation of molecular mechanisms of neurological diseases based on genome analysis
- 2007 - 2008 The spectrum of pathological involvement in Japanese multiple system atrophy
- 2005 - 2007 Atherapeutic approach to polyglutamine diseases by the activation of cellularproteolyticpathways
- 2004 - 2005 内在性相補鎖RNAによる遺伝子発現調節機構に注目したシヌクレイン関連蛋白の解析
- 2004 - 2005 New polyglutamine diseases : from the neuropathologies to the identification of genes responsible for the diseases
- 2003 - 2004 Transcriptional disturbance and Neurodegeneration.
- 2000 - 2004 Molecular mechanisms of neurodegeneration
- 2002 - 2003 Identified the causative gene for EAOH end elucidation the molecular mechanisms of neurodegeneration in EAOH
- 2001 - 2002 Research for the role of dystrophic neurites in neuronal cell dysfunction of Polyglutamine disease
- 2000 - 2001 Elucidation of molecular mechanisms of neurodegenerative diseases caused by expansion of CAG repeats
- 1999 - 2000 ポリグルタミン病における凝集体と神経細胞死の関連の解明と凝集体阻害剤の探求
- Neurodegenerative diseases
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Papers (441):
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Shoko Hongo, Hiroshi Shimizu, Etsuji Saji, Akihiro Nakajima, Kouichirou Okamoto, Izumi Kawachi, Osamu Onodera, Akiyoshi Kakita. Acute respiratory failure caused by brainstem demyelinating lesions in an older patient with an atypical relapsing autoimmune disorder. Neuropathology. 2024
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Yukiko Kinoshita, Masahiro Hatakeyama, Mika Otsuki, Takanobu Ishiguro, Etsuji Saji, Masato Kanazawa, Osamu Onodera. Cerebellar compensation: a case of aphasia due to cerebellar hemorrhage. Journal of Neurology. 2024
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Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, et al. Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD. Acta Neuropathologica Communications. 2024. 12. 1
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Kanako Kurihara, Shinsuke Fujioka, Yasuaki Mizutani, Hirohisa Watanabe, Kazuhiro Iwaoka, Tetsuya Maeda, Morinobu Seki, Toshiki Tezuka, Jin Nakahara, Takuya Konno, et al. Validation study of the Japanese version of the King's Parkinson's Disease Pain Scale and the King's Parkinson's Disease Pain Questionnaire. Parkinsonism & related disorders. 2024. 120. 106012-106012
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Itaru Ninomiya, Akihide Koyama, Yutaka Otsu, Osamu Onodera, Masato Kanazawa. Corrigendum: Regeneration of the cerebral cortex by direct chemical reprogramming of macrophages into neuronal cells in acute ischemic stroke. Frontiers in cellular neuroscience. 2024. 18. 1372045-1372045
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MISC (858):
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畠野雄也, 畠野雄也, 石原智彦, 小野寺理. 研究手法 MOVA:AlphaFold2によるミスセンスバリアントの効果予測. 遺伝子医学. 2024. 14. 1
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坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 小野寺理, et al. TDP-43 differentially propagates to induce degeneration in the motor circuit. Dementia Japan. 2023. 37. 4
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森秀樹, 坪口晋太朗, 佐藤時春, 中村由香, 加藤泰介, 須貝章弘, 小野寺理, 上野将紀. TDP-43変異型により異なる病態進展特性の解析. Dementia Japan. 2023. 37. 4
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小出伸, 坪口晋太朗, 二宮格, 齋藤太希, 石黒敬信, 佐治越爾, 鈴木倫明, 金澤雅人, 小野寺理. 脳血管造影検査後の発熱・意識障害で診断された神経核内封入体病(NIID)の一例. 臨床神経学(Web). 2023. 63. 3
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畠山祐樹, 坪口晋太朗, 石黒敬信, 佐治越爾, 細島康宏, 片桐隆幸, 金澤雅人, 小野寺理. 初期にCastleman病が疑われ特徴的な神経伝導検査所見を呈した61歳男性例. 臨床神経学(Web). 2023. 63. 4
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Patents (2):
Books (3):
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厚生労働科学研究費補助金難治性疾患克服研究事業遺伝性脳小血管病の病態機序の解明と治療法の開発班研究報告書
[小野寺理] 2010
-
転写障害に注目した神経変性過程の解明
[小野寺理] 2005
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アプラタキシン欠損症の臨床遺伝学的検討および病態機序の解明
辻省次 2004
Education (2):
- 1989 - 1993 Niigata University
- 1981 - 1987 Niigata University Faculty of Medicine
Work history (7):
- 2022/09 - 現在 新潟大学医歯学付属病院病院長補佐
- 2020/04 - 現在 Niigata University Brain Research Institute Clinical Neuroscience Branch Department of Neurology Professor
- 2020/02 - 現在 Director of Brain Research Institute
- 2020/07 - 2022/08 新潟大学医歯学総合病院 副院長
- 2016/04 - 2020/03 Niigata University Brain Research Institute Clinical Neuroscience Branch Department of Neurology Professor
- 2010/10 - 2016/03 Niigata University Brain Research Institute
- 2002 - 2010 Niigata University Brain Research Institute
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Committee career (3):
- 2018/08 - 現在 Neurochemistry International Associate Editor
- 2018/05 - 現在 日本神経学会 理事
- 2017/10 - 現在 日本認知症学会 理事
Awards (4):
- 2021/11 - 新潟日報文化賞
- 2009 - 新潟大学 新潟大学学長表彰
- 2008 - 日本神経学会 日本神経学会賞
- 2002 - ベルツ賞 佳作賞
Association Membership(s) (7):
日本内化学会
, 脳卒中学会
, 神経治療学会
, 日本神経科学会
, Society of Movement Disorder
, ASHG
, 日本神経学会
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