Rchr
J-GLOBAL ID：200901076586221994   Update date: Oct. 17, 2024

Kenichiro Nagai

ナガイ ケンイチロウ | Kenichiro Nagai
Affiliation and department：
Kitasato University

About Kitasato University


Research field  (4)： Pharmaceuticals - chemistry and drug development ,  Analytical chemistry ,  Bioorganic chemistry ,  Structural/physical organic chemistry
Research keywords  (1)： Bioorganic Chemistry
Research theme for competitive and other funds  (7)：
  • 2022 - 2025 Study on naturally-occurring peptides potentiating amphotericin B activity
  • 2022 - 2025 トリプルネガティブ乳がん共通のバイオロジーを標的とした新規医薬品の探索
  • 2019 - 2022 Study on cyclic peptides with amphotericin B potentiating activity
  • 2015 - 2018 Discovery of new anti-infectives based on chemical biology
  • 2014 - 2017 Analysis of molecular targets and development into drug discovery for cyclic peptides possessing thrombolysis-enhancing action
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Papers (52)：
  • Ryota Okamura, Katsuki Kikuchi, Akito Taniguchi, Kenichiro Nagai, Reiko Seki, Satoshi Ohte, Taichi Ohshiro, Masashi Ando, Teruyoshi Tanaka, Takashi Fukuda. The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612. The Journal of Antibiotics. 2024
  • Keisuke Kobayashi, Rio Tejima, Kenichiro Nagai, Reiko Seki, Tsuyoshi Hosoya, Yumi Une, Satoru Shigeno, Hiroshi Tomoda, Taichi Ohshiro. Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21. The Journal of antibiotics. 2024
  • Satoru Shigeno, Miyu Kadowaki, Kenichiro Nagai, Kanji Hosoda, Takeshi Terahara, Tomoyasu Nishimura, Naoki Hasegawa, Hiroshi Tomoda, Taichi Ohshiro. New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239. The Journal of Antibiotics. 2024
  • Kenichiro Nagai, Keisuke Kobayashi, Ryosuke Miyake, Yukino Sato, Reiko Seki, Takashi Fukuda, Akiho Yagi, Ryuji Uchida, Taichi Ohshiro, Hiroshi Tomoda. Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity. The Journal of Antibiotics. 2024
  • Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, et al. Anti-Schistosomal Activity and ADMET Properties of 1,2,5-Oxadiazinane-Containing Compound Synthesized by Visible-Light Photoredox Catalysis. RSC Medicinal Chemistry. 2024
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MISC (8)：
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Patents (5)：
  • 抗真菌薬に対する活性増強作用を有する新規環状ペプチド化合物及びその製造方法
  • Preparation of Beauveriolide Derivatives as Inhibitors of Acyl CoA Cholesterol Transacylase
  • Preparation of Beauveriolide Derivatives as Inhibitors of Acyl CoA Cholesterol Transacylase
  • Novel Dihydropseudoerythromycin Derivatives as Antiinflammatory Agents
  • 4"-アルキリデンエバ-メクチン誘導体(特願平11-31058)
Lectures and oral presentations  (25)：
  • 海洋由来放線菌 Streptomyces sp. KKMA-0239 株が生産する新規 polycyclic tetramate macrolactam 類に関する研究
    (日本薬学会第144年会(横浜) 2024)
  • 真菌Talaromyces cellulolyticus BF-0307株が生産する新規イソベンゾフラン celludinone C に関する研究
    (日本薬学会第144年会(横浜) 2024)
  • 深海由来微生物を用いたメラノーマ選択的抗がん活性を有する化合物の探索
    (日本薬学会第144年会(横浜) 2024)
  • 新規 1,2,5-オキサジアジナン誘導体: 光化学的合成, 抗住血吸虫活性, ADMET 特性
    (日本薬学会第144年会(横浜) 2024)
  • Amphotericin B 活性増強物質 nectriatide 誘導体の合成と活性評価
    (日本薬学会第144年会(横浜) 2024)
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Education (1)：
  • - 1999 Kitasato University Graduate School, Division of Pharmaceutical Sciences
Professional career (2)：
  • 修士(薬学) (北里大学)
  • 博士(薬学) (北里大学)
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