Kenichiro Nagai

ナガイケンイチロウ | Kenichiro Nagai

Affiliation and department：

Research field (4)： Pharmaceuticals - chemistry and drug development , Analytical chemistry , Bioorganic chemistry , Structural/physical organic chemistry

Research keywords (1)： Bioorganic Chemistry

Research theme for competitive and other funds (7)：

2022 - 2025 Study on naturally-occurring peptides potentiating amphotericin B activity
2022 - 2025 トリプルネガティブ乳がん共通のバイオロジーを標的とした新規医薬品の探索
2019 - 2022 Study on cyclic peptides with amphotericin B potentiating activity
2015 - 2018 Discovery of new anti-infectives based on chemical biology
2014 - 2017 Analysis of molecular targets and development into drug discovery for cyclic peptides possessing thrombolysis-enhancing action

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Papers (51)：

Ryota Okamura, Katsuki Kikuchi, Akito Taniguchi, Kenichiro Nagai, Reiko Seki, Satoshi Ohte, Taichi Ohshiro, Masashi Ando, Teruyoshi Tanaka, Takashi Fukuda. The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612. The Journal of Antibiotics. 2024
Keisuke Kobayashi, Rio Tejima, Kenichiro Nagai, Reiko Seki, Tsuyoshi Hosoya, Yumi Une, Satoru Shigeno, Hiroshi Tomoda, Taichi Ohshiro. Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21. The Journal of antibiotics. 2024
Satoru Shigeno, Miyu Kadowaki, Kenichiro Nagai, Kanji Hosoda, Takeshi Terahara, Tomoyasu Nishimura, Naoki Hasegawa, Hiroshi Tomoda, Taichi Ohshiro. New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239. The Journal of Antibiotics. 2024
Kenichiro Nagai, Keisuke Kobayashi, Ryosuke Miyake, Yukino Sato, Reiko Seki, Takashi Fukuda, Akiho Yagi, Ryuji Uchida, Taichi Ohshiro, Hiroshi Tomoda. Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity. The Journal of Antibiotics. 2024
Moeka Uemura, Keisuke Kobayashi, Noriko Sato, Kenichiro Nagai, Reiko Seki, Michiya Kamio, Takashi Fukuda, Taishi Tsubouchi, Hiroshi Tomoda, Taichi Ohshiro, et al. Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8. The Journal of Antibiotics. 2023

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MISC (7)：

小林啓介, 内田龍児, 福田隆志, 長光亨, 長井賢一郎, 供田洋. 創薬を支える独創的な技術開発:抗真菌薬活性増強剤の開拓. 化学工業. 2021. 72. 1. 28-37
廣瀬友靖, 廣瀬友靖, 中島琢自, 高田拓和, 岩月正人, 岩月正人, 山田健, 山田健, 落合純也, 神谷義之, et al. Mangromicin A with Potent Antitrypanosomal Activity; Isolation, Structure Elucidation and Asymmetric Total Synthesis. 天然有機化合物討論会講演要旨集(Web). 2017. 59th
石島広之, 内田龍児, 大多和正樹, 近藤あり子, 長井賢一郎, 島圭介, 野中健一, 増間緑郎, 岩本晋, 小野寺秀幸, et al. 真菌が生産する新規抗真菌活性物質simplifunginおよびvalsafungin類に関する研究. 天然有機化合物討論会講演要旨集(Web). 2016. 58th
砂塚敏明, 砂塚敏明, 砂塚敏明, 菅原章公, 長井賢一郎, 野口吉彦, 井口加奈美, 塩見和朗, 塩見和朗, 塩見和朗, et al. キチナーゼ阻害剤Argifinの固相全合成. 日本薬学会年会要旨集. 2007. 127th. 4
DOI Takayuki, NAGAI Kenichiro, SEKIGUCHI Takafumi, FUJIMOTO Nobuaki, NAMATAME Ichiji, SUNAZUKA Toshiaki, TOMODA Hiroshi, OMURA Satoshi, TAKAHASHI Takashi. Synthesis and Biological Evaluation of a Beauveriolide Analogue Library. 2006. 2005. 51-52

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Patents (5)：

抗真菌薬に対する活性増強作用を有する新規環状ペプチド化合物及びその製造方法
Preparation of Beauveriolide Derivatives as Inhibitors of Acyl CoA Cholesterol Transacylase
Preparation of Beauveriolide Derivatives as Inhibitors of Acyl CoA Cholesterol Transacylase
Novel Dihydropseudoerythromycin Derivatives as Antiinflammatory Agents
4"-アルキリデンエバ-メクチン誘導体(特願平11-31058)

Lectures and oral presentations (25)：

海洋由来放線菌 Streptomyces sp. KKMA-0239 株が生産する新規 polycyclic tetramate macrolactam 類に関する研究
(日本薬学会第144年会(横浜) 2024)
真菌Talaromyces cellulolyticus BF-0307株が生産する新規イソベンゾフラン celludinone C に関する研究
(日本薬学会第144年会(横浜) 2024)
深海由来微生物を用いたメラノーマ選択的抗がん活性を有する化合物の探索
(日本薬学会第144年会(横浜) 2024)
新規 1,2,5-オキサジアジナン誘導体: 光化学的合成, 抗住血吸虫活性, ADMET 特性
(日本薬学会第144年会(横浜) 2024)
Amphotericin B 活性増強物質 nectriatide 誘導体の合成と活性評価
(日本薬学会第144年会(横浜) 2024)

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Education (1)：

- 1999 Kitasato University Graduate School, Division of Pharmaceutical Sciences

Professional career (2)：

修士(薬学) (北里大学)
博士(薬学) (北里大学)

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