Sasaki Makoto

ササキマコト | Sasaki Makoto

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Tohoku University Faculty of Agriculture, Tohoku University

Homepage URL (1)： http://sasaki-umehara-lab.moon.bindcloud.jp

Research field (3)： Bioorganic chemistry , Structural/physical organic chemistry , Molecular biochemistry

Research keywords (6)： Caribbean ciguatoxin , excitatory amino acid , glutamate receptors , biologically functional molecules , polycyclic ether natural products , total synthesis

Research theme for competitive and other funds (32)：

2005 - 現在 Stereostructure and total synthesis of goniodomin A
2004 - 現在 Studies toward the total synthesis of antifungal polycyclic ether, gambieric acid A
1998 - 現在 Studies toward total synthesis of azaspiracid
1996 - 現在興奮神経毒アミノ酸の全合成と機能解析
1993 - 現在 Total Synthesis and Function of Polycyclic Ether Natural Products

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Papers (205)：

Daisuke Sato, Makoto Sasaki, Atsushi Umehara. Stereocontrolled Synthesis of the Portimine Skeleton via Organocatalyst-Mediated Asymmetric Stannylation and Stereoretentive C(sp3)-C(sp2) Stille Coupling. Organic Letters. 2025. 27. 942-947
Makoto Sasaki, Miyu Ohba, Ako Murakami, Atsushi Umehara. Convergent and Scalable Synthesis of Fully Functionalized HIJKLMN-Ring Segment of Caribbean Ciguatoxin C-CTX-1. The Journal of Organic Chemistry. 2024. 89. 18631-18639
Atsushi Umehara, Ko-hei Kawakita, Makoto Sasaki. Total Synthesis of (-)-Zearalenone and (-)-Zearalanone: A Macrocyclization Strategy by Ni/Zr/Cr-Mediated Reductive Ketone Coupling. The Journal of Organic Chemistry. 2024. 89. 13800-13805
Tomoya Suwa, Makoto Sasaki, Atsushi Umehara. Total Synthesis of (-)-Irijimaside A Enabled by Ni/Zr-Mediated Reductive Ketone Coupling. Organic Letters. 2024. 26. 20. 4377-4382
Atsushi Umehara, Soma Shimizu, Makoto Sasaki. DMAPO/Boc2O-Mediated One-Pot Direct N1-Acylation of Indazole with Carboxylic Acids: A Practical Synthesis of N1-Functionalized Alkyl Indazoles. European Journal of Organic Chemistry. 2024. e202400123

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MISC (68)：

Haruhiko Fuwa, Makoto Sasaki. Exploiting Ruthenium Carbene-Catalyzed Reactions in Total Synthesis of Marine Oxacyclic Natural Products. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN. 2016. 89. 12. 1403-1415
Makoto Sasaki, Haruhiko Fuwa. Total Synthesis and Complete Structural Assignment of Gambieric Acid A, a Large Polycyclic Ether Marine Natural Product. CHEMICAL RECORD. 2014. 14. 4. 678-703
A CONCISE SYNTHESIS OF THE AB-RING FRAGMENT OF (-)-GAMBIEROL (Dedicated to Professor Dr. Ei-ichi Negishi on the occasion of his 77th birthday). Heterocycles : an international journal for reviews and communications in heterocyclic chemistry. 2012. 86. 1. 127-132
UNNO Masaki, SASAKI Makoto, SAKAI Ryuichi, IKEDA SAITO Masao. Binding Modes and the Selectivity of the Compounds Bound to the Kainate-Type Glutamate Receptors at Atomic Level Resolution. Nihon Kessho Gakkaishi. 2012. 54. 6. 338-344
Masaki Unno, Ryuichi Sakai, Makoto Sasaki, Masao Ikeda-Saito. Binding and Selectivity of the Marine Toxin Neodysiherbaine A, and its Synthetic Analogues, to GluK1 and GluK2 Kainate Receptors. Photon Factory Activity Reprot 2011, Part B. 2012. 29. 320

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Patents (6)：

ポリ環状エーテル化合物とギムノシン-Aの合成方法
メチルチオメチル基で修飾されたエチレングリコールポリマー、その合成方法及びその利用
ガンビエロールの製造方法
環状ポリエーテル化合物の製造方法
Process for Preparing cyclic polyethers

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Books (34)：

理科年表 2025
丸善出版 2024 ISBN:9784621310304
理化年表 2024
丸善出版株式会社 2023
ドラマチック有機合成化学感動の瞬間100
2023 ISBN:9784759823363
解説:創薬化学研究に貢献する新しいアミド結合形成反応-反応性の低い窒素求核剤とカルボン酸の高効率one-pot縮合反応の開発
化学同人 2023
理化年表 2023
2022

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Lectures and oral presentations (289)：

Synthetic Studies on Portimine
(2025)
Total Synthesis of Irijimasides
(2025)
致死性海藻食中毒原因物質ポリカバノシド類の作用機序およぼ新規ポリカバノシド累延滞の構造と毒性
(第66回天然有機化合物討論会 2024)
イリジマシド類の不斉全合成
(第66回天然有機化合物討論会 2024)
Synthetic Studies on Irijimasides Using Ni-Catalyzed Ketone Coupling
(The 15th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC) 2023)

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Education (1)：

- 1989 The University of Tokyo Graduate School, Division of Science Department of Chemistry

Professional career (1)：

理学博士 (The University of Tokyo)

Work history (10)：

2002/04 - 現在 Professor, Graduate School of Life Sciences, Tohoku University
2023/10 - 2024/03 Osaka University Graduate School of Science
2004/04 - 2005/03 関西学院大学大学院理工学研究科非常勤講師
2001/04 - 2002/03 Associate Professor, Graduate School of Science, The University of Tokyo
2001/04 - 2002/03 Associate Professor, Graduate School of Life Sciences, Tohoku University

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Committee career (30)：

2006/04 - 現在万有仙台シンポジウム組織委員会仙台シンポジウム組織委員
2021/12 - 2023/11 公益社団法人有機合成化学協会代議員
2016/09 - 2016/10 日本化学会第31回「若い世代の特別講演会」講演者選考委員会分野別選考委員会委員
2016/09 - 2016/10 日本化学会第31回「若い世代の特別講演会」講演者選考委員会分野別選考委員会委員
2016/09 - 平成28年度日本化学会学術賞・進歩賞分野別選考委員会委員

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Awards (4)：

2014/01/14 - 有機合成化学協会 2013年度有機合成化学協会「第一三共・創薬有機化学賞」巨大複雑天然物の高効率的な全合成
2006/10/19 - アジア最先端有機化学国際会議組織委員会アジア最先端有機化学国際会議 Lectureship Award受賞
2006/03/28 - 社団法人日本化学会平成17年度日本化学会学術賞新規ポリエーテル骨格合成法の開発と天然物全合成への展開
1992/02 - 財団法人・井上科学振興財団 Inoue Research Award for Young Scientists

Association Membership(s) (4)：

Japan Society for Bioscience, Biotechnology, and Agrochemistry , The Society of Synthetic Organic Chemistry, Japan , American Chemical Society , The Chemical Society of Japan

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