Rchr
J-GLOBAL ID：200901076730260436
Update date: Mar. 07, 2024
Komatsu Kenshi
コマツ ケンシ | Komatsu Kenshi
Affiliation and department：
Job title：
Project Professor
Homepage URL (1)：
http://www.rbc.kyoto-u.ac.jp
Research field (2)：
Cell biology
, Environmental effects of radiation
Research keywords (6)：
細胞生物学
, 分子生物学
, 放射線生物学
, Cell biology
, Molecular biology
, Radiobiology
Research theme for competitive and other funds (48)：
- 2014 - 2018 Role of NBS1 C-terminal domain in genomic stability
- 2014 - 2016 The experimental verification of saturated repair model by using repair reporter genes.
- 2013 - 2015 多重ドメイン蛋白によるユビキチンシグナルの選択性と疾患
- 2013 - 2015 Generation of ES cells to meseare DNA repair activity with reporter genes
- 2011 - 2015 Roles of newly discovered NBS1 domains in ubiquitin signals and rejoining of double-strand breaks after irradiation
- 2013 - 2014 Contribution of translesional DNA synthesis to UV-induced damage during embryogenesis and at low dose-rate.
- 2010 - 2012 Functional analysis of Sox11 and Plagl1 in glioma stem cells.
- 2011 - 2011 Molecular mechanism of radiation/NBS1-associated microcephaly
- 2010 - 2010 グリオブラストーマ幹細胞のDNA修復能
- 2006 - 2010 Induction of DNA double strand break by environmental genotoxic and carcinogenic agents
- 2005 - 2009 FUNCTIONAL ANALYSIS OF CANCER-SUSCEPTIBIE GENE, NBS1
- 2002 - 2005 Origin of radiation-induced genomic instability
- 2002 - 2004 Molecular cloning of the gene for cancer-prone syndrome characterized by abnormal mitotic spindle checkpoint.
- 2000 - 2004 Cancersusceptibility disease Nijmegen Breakage Syndrome and the function of underlying gene.
- 2001 - 2003 Environmental behaviour of tritium and assessment of public absorption dose tritium
- 2001 - 2002 DNA double strand break repair by NBS1 complex.
- 2000 - 2002 Mechanisms of cell responses by low dose and low dose-rate irradiation
- 2000 - 2002 Development of molecular bio-dosimeiry and monitor mice for the detection of radiation dose exposed by tritium water
- 1998 - 2002 Novel developments on genetic recombination : DNA double-strand break and DNA end-joining
- 2000 - 2001 Molecular mechanism for chromosome stability using Nbs1 knockout mice
- 2000 - 2001 Role of NBS1 in Repair of DNA damage Induced by Ionizing Radiation
- 1999 - 2000 Tritium behavior in the environment and absorption dose
- 1998 - 2000 Study on underlying gene of Nijmegen Breakage Syndrome
- 1999 - 1999 放射線感受性予測の基礎研究
- 1999 - 1999 Generation of knockout mice for Nijmegen breakage syndrome gene, NBS1.
- 1998 - 1999 Complementation assisted positional cloning of the gene for AT variant.
- 1998 - 1998 染色体8q21上の放射線誘発DNA二重鎖切断からの修復遺伝子のクローニング
- 1997 - 1998 Development of (a human X-chromosome * hamster) hybrid cell assay system, which is sensitive to tritium exposure.
- 1997 - 1998 Studies on energy dependency of biological effects of neutrons and risk estimation
- 1997 - 1997 高発癌遺伝病ナイミ-ヘン染色体不安定症候群の原因遺伝子の単離
- 1996 - 1997 Molecular study on Nijmegen breakage sybdrome
- 1996 - 1997 Multi-functions of DNA-dependent protein kinase (DNA-PK) and the association of radiation sensitivity
- 1996 - 1997 Molecular mechanism of initiation of X inactivation using Xist YAC transgenic mouse
- 1996 - 1996 放射線感受性予測の基礎研究
- 1995 - 1996 Research and development of transgenic mouse for biological effect assesment of tritium
- 1995 - 1996 Development of a method of neutron spectrum measurement for monoenergetic neutrons generated from an accelerator for the use of radiation biology
- 1995 - 1995 免疫不全症およびDNA修復欠損の原因遺伝子HYRCの特性と単離
- 1994 - 1995 Study on biological effectiveness of organic bound tritium by using DNA deficient cells.
- 1994 - 1994 免疫不全症およびDNA修復欠損の原因遺伝子HYRCの特性と単離
- 1992 - 1992 V(D)Jリコンビネース欠損突然変異を用いたDNA修復機序の解析
- 1990 - 1991 The Mechanism of Hyper-radiosensitivity Expressed in Ataxia telangiectasia Disease.
- 1990 - 1990 DNA修復能力と毛細血管拡張性運動失調症(AT)形質発現の解析
- 1990 - 1990 生体に与える低濃度トリチウムの長期被曝実験の検討
- 1988 - 1989 Modulating Effect of Protein Kinase C Activator on Radiation-Induced Transformation
- 1988 - 1988 実験発がん系におけるトリチウム水のRBE
- 1983 - 1983 環境トリチウムの食物摂取とリスク推定に関する研究
- DNA二重鎖切断の修復とダメージレスポンス
- The underlying Mechanisms for Radiation Sensitivity
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Papers (148)：
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Haruki Nagashima, Yuki Hayashi, Yuki Sakamoto, Kenshi Komatsu, Hiroshi Tauchi. Induction of somatic mutations by low concentrations of tritiated water (HTO): evidence for the possible existence of a dose-rate threshold. Journal of Radiation Research. 2021. 62. 4. 582-589
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Yuichiro Saito, Junya Kobayashi, Masato T Kanemaki, Kenshi Komatsu. RIF1 controls replication initiation and homologous recombination repair in a radiation dose-dependent manner. Journal of cell science. 2020. 133. 12
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Haruki Nagashima, Kumiko Shiraishi, Saori Ohkawa, Yuki Sakamoto, Kenshi Komatsu, Shinya Matsuura, Akira Tachibana, Hiroshi Tauchi. Induction of somatic mutations by low-dose X-rays: the challenge in recognizing radiation-induced events. Journal of Radiation Research. 2018. 59. suppl_2. ii11-ii17
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Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N. Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS-Activated TGFβ Signaling. Mol Cancer Res. 2018. 16. 11. 1676-1686
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Tsutomu Shimura, Megumi Sasatani, Hidehiko Kawai, Kenji Kamiya, Junya Kobayashi, Kenshi Komatsu, Naoki Kunugita. ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts. Cell Cycle. 2017. 16. 24. 2345-2354
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MISC (97)：
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井原 誠, 斎藤 裕一郎, 小林 純也, 栗政 明弘, 小松 賢志, 工藤 崇. 相同組換えにおけるATMのポジテブとネガテブな役割. 日本放射線影響学会大会講演要旨集. 2017. 60回. 159-159
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井原 誠, 小林 純也, 栗政 明弘, 小松 賢志, 工藤 崇. Ku欠失細胞における相同組換え修復. 日本放射線影響学会大会講演要旨集. 2013. 56回. 162-162
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小松 賢志, 柳原 啓見. 放射線によるDNA損傷の応答機構. BIO Clinica. 2012. 27. 5. 428-432
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KATO Akihiro, KOMATSU Kenshi. The interaction between MRN complex and RAD51. The Japan Radiation Research Society Annual Meeting Abstracts. 2011. 2011. 0. 204-204
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Oliveira DV, Nakamura K, Kato A, Kobayashi J, Ikura T, Komatsu K. Facilitates Chromatin Transcription complex, FACT, on DNA repair. 第54 回日本放射線影響学会, 2011 年11 月, 神戸. 2011
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Patents (1)：
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DNA鎖間架橋の測定方法およびDNA鎖間架橋の修復速度の測定方法
Books (8)：
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Contemporary Radiobiology (単著)
Cambridge Scholar Publishing, UK 2019
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[DNA修復とゲノム不安定性]がん生物学イラストレイテッド第2版
洋土社 2019
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現代人のための放射線生物学 (単著)
京都大学学術出版会 2017
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ナイミーヘン症候群””先天代謝異常症候群
日本臨床社 2012
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放射線によるDNA損傷の応答機構”バイオクリニカ”
北隆館 2012
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Lectures and oral presentations (14)：
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放射線生物学の最前線と低線量放射線リスクー突然変異の起源から探るー
(第55回日本医学放射線学会教育講演 2019)
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NBS1タンパクからDNA損傷応答を読み解く
(「2018年度基礎臨床社会医学統合」東京大学医学部講義 2018)
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Radiation-associated repair and DNA Repair Network
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organiser
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「ゲノムに学ぶ危機管理と人類の出自」
(平成21 年度秋田工業高 等専門学校特別講演会, 秋田県民会館。 2009)
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Education (1)：
Professional career (1)：
- (BLANK) (Tohoku University)
Work history (7)：
- 2015 - 現在 Kyoto University Graduate School of Biostudies, Radiation Biology Center Project Professor, Professor Emeritus
- 2002 - 2015 Kyoto University Radiation Biology Center Professor
- 2003 - 2009 Kyoto University Radiation Biology Center Director
- 1994 - 2002 Hiroshima University Research Institute for Radiation Biology and Medicine Professor
- 1987 - 1994 Nagasaki University Atomic Bomb Disease Institute Lecturer, Associate Professor
- 1984 - 1987 Columbia University Laboratory of Radiation zresearch Visiting Researcher
- 1978 - 1984 Tohoku University Faculty of Medicine School of Medicine Assistant Professor
Show all
Committee career (5)：
- 2014 - 2018 Journal of Radiation Research Editor-in-Chief
- 2006 - 2016 The Japanese Radiation Research Society Councilor
- 2010 - 2014 Japanese Cancer Association Councilor
- 2009 - 2013 文部科学省 放射線審議会委員
- 2008 - 2010 内閣府 原子力安全委員会専門委員
Awards (2)：
- 2020 - Radiation Effect Association Distiguished Achievement Award Molecular studies on radiation sensitive disease, Nijmegen Breackage Syndrome
- 2009 - The Japanese Radiation Reasearch Society Distinguished Scientist Award Studies on the underlying gene, NBS1, Nijmegen Breackage Syndrome
Association Membership(s) (1)：
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