Hayashi Hidetoshi

ハヤシヒデトシ | Hayashi Hidetoshi

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://taisha-phar.jimdo.com

Research field (2)： Pharmaceuticals - health and biochemistry , Tumor biology

Research keywords (11)：ユビキチン化 , Epithelial-Mesenchymal Transition , drug repositioning , ER stress , cancer molecular target drugs , TGF-beta , deubiquitination , glucose and lipid metabolism , inflammation , 生活習慣病 , cellular stress

Research theme for competitive and other funds (29)：

2020 - 2023 Development of anticancer drugs based on a new oncogenic mechanism of a novel oncogene candidate molecule TRB1
2015 - 2018 Mechanism of conversion of TGF-beta from tumor suppressor to malignant factor by post-translational modification control
2015 - 2018 新規がん遺伝子TRBファミリー分子による発癌作用の分子基盤の解明
2012 - 2015 ストレス誘導性分子TRB1, TRB3によるストレス制御と疾患発症の分子メカニズム
2009 - 2012 メタボリックシンドロームにおけるストレスとサイトカインシグナルのクロストーク

2006 - 2008 腫瘍細胞に高発現するdecoy kinase TRB3の機能解析

2006 - 2008 ストレスセンサー分子TRBによる脂肪細胞の機能制御

2006 - 2008 新規kinase様タンパクTRBファミリーによる細胞の増殖・分化の制御

2004 - 2006 外的ストレスにおけるCHOP依存的な細胞死の分子基盤

2005 - 2006 関節リウマチと化学物質に関する研究

2002 - 2004 内分泌攪乱物質による免疫応答の攪乱作用

2004 - 2004 抗腫瘍活性の増強と毒性軽減を示す糖鎖結合TNFαの作用機構の解析

2002 - 2004 Study on the action mechanism of IL-1 and its regulation

2001 - 2003 TGFβの情報伝達分子Smadタンパクの分解によるシグナル伝達の制御機構

1999 - 2001 担癌状態におけるTGFβを介した免疫抑制作用の基礎的研究

2001 - 2001 BCGワクチン、結核菌毒力の新しい評価法の開発

1999 - 2001 The mechanism and its regulation of interleukin 1 biological activities

2000 - 2000 腫瘍細胞におけるインターロイキン1の作用発現制御に関する研究

1996 - 1997 Study on interleukin 1 signal transduction

1994 - 1996 インタ-ロイキン1の構成的産生ヒトメラノ-マ細胞の癌原性及び転移能に関する研究

1994 - 1996 インタ-ロイキン1の細胞増殖阻害作用に対する耐性獲得機構の解析

1995 - 1996 Development of IL-1 with selective activities by introduction of carbohydrates

1994 - 1995 Study on the interleukin-1 signaling

1993 - 1994 サイトカインによる腫瘍細胞障害性機序の解析

1992 - 1994 IL-1によるマウスT細胞株の増殖シグナル伝達機構の解析

1992 - 1993 メラノーマ細胞株のIL-1産生とその増殖制御

1992 - 1993 The mechanism of the acquired resistance to the anti-proliferative effect of IL-1 on human melanoma cells.

1990 - 1992 新しいタイプのリソゾーム膜ATPaseの精製及びその構造解析

1988 - 1990 リソゾーム膜プロトンポンプの精製及びその構造解析

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Papers (131)：

Satoru Takeshita, Hiroki Kakita, Nami Nakamura, Mari Mori, Kohki Toriuchi, Hiromasa Aoki, Yasumichi Inoue, Hidetoshi Hayashi, Yasumasa Yamada, Mineyoshi Aoyama. Thrombopoietin exerts a neuroprotective effect by inhibiting the suppression of neuronal proliferation and axonal outgrowth in intrauterine growth restriction rats. Experimental neurology. 2024. 114781-114781
Aya Yamamura, Moe Fujiwara, Akiko Kawade, Taiki Amano, Alamgir Hossain, Md Junayed Nayeem, Rubii Kondo, Yoshiaki Suzuki, Yasumichi Inoue, Hidetoshi Hayashi, et al. Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension. European journal of pharmacology. 2024. 176564-176564
Mai Nagasaka, Chiharu Miyajima, Yasumichi Inoue, Sakura Hashiguchi, Yuya Suzuki, Daisuke Morishita, Hiromasa Aoki, Kohki Toriuchi, Ryohei Katayama, Mineyoshi Aoyama, et al. ID3 is a novel target gene of p53 and modulates lung cancer cell metastasis. Biochemical and Biophysical Research Communications. 2024. 149789-149789
Naoya Fukuda, Kohki Toriuchi, Rina Mimoto, Hiromasa Aoki, Hiroki Kakita, Yoshiaki Suzuki, Satoru Takeshita, Tetsuya Tamura, Hisao Yamamura, Yasumichi Inoue, et al. Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4. Neurochemical Research. 2023
Mai Nagasaka, Yasumichi Inoue, Yuji Nagao, Chiharu Miyajima, Daisuke Morishita, Hiromasa Aoki, Mineyoshi Aoyama, Takeshi Imamura, Hidetoshi Hayashi. SET8 is a novel negative regulator of TGF-β signaling in a methylation-independent manner. Scientific Reports. 2023. 13. 1

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MISC (25)：

Katsuhiko Muraki, Hiroka Suzuki, Noriyuki Hatano, Yukiko Muraki, Yuka Itoh, Hidetoshi Hayashi, Kikuo Onozaki. Potent activation of TRPA1 channel by NADPH oxidase inhibitors. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 171P-171P
Noriyuki Hatano, Yuka Itoh, Hiroka Suzuki, Yukiko Muraki, Hidetoshi Hayashi, Kikuo Onozaki, Ian Wood, David Beech, Katsuhiko Muraki. Inflammatory stimulation induces expression of TRPA1 channel to regulate cytokine release. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 158P-158P
Noriyuki Hatano, Yuka Itoh, Hiroka Suzuki, Yukiko Muraki, Hidetoshi Hayashi, Kikuo Onozaki, Ian Wood, David Beech, Katsuhiko Muraki. Transcriptional regulation of transient receptor potential ankyrin 1 channel gene expression by hypoxia inducible factor-1 alpha. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 234P-234P
坂井勇斗, 深町勝巳, 二口充, 林秀敏, 酒々井眞澄. マウス乳癌細胞株を用いたpseudokinase TRB3の機能解析(TRB3 gene increases cell proliferation in mouse mammary carcinoma cells). 日本癌学会総会記事. 2012. 71回. 240-240
坂井勇斗, 深町勝巳, 二口充, 津田洋幸, 酒々井眞澄, 林秀敏. Apc欠損によって引き起こされる大腸腫瘍発生におけるTRB3の役割(The Role of TRB3 in colorectal tumorigenesis by disruption of Ape). 日本癌学会総会記事. 2011. 70回. 162-162

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Education (2)：

1982 - 1987 The University of Tokyo Graduate School of Pharmaceutical Sciences
1978 - 1982 The University of Tokyo

Professional career (1)：

博士(薬学) (東京大学)

Work history (7)：

2008/04 - 現在 Nagoya City University Graduate School of Pharmaceutical Sciences
1996/01 - 2008/03 Nagoya City University Graduate School of Pharmaceutical Sciences
1996/09 - 1998/03 The Hospital for Sick Children In Toronto 客員研究員
1992/05 - 1995/12 Nagoya City University Medicin
1990/04 - 1992/04 Nagoya City University Medicin

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Association Membership(s) (8)：

International Cytokine Society , the American Society for Cell Biology , 日本脂質生化学会 , 日本生化学会 , 日本免疫学会 , 日本分子生物学会 , 日本癌学会 , 日本薬学会

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