Research field (2)：
Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (4)：
β-glucan
, Allergy
, 免疫薬理学
, Immunopharmacology
Research theme for competitive and other funds (15)：
2023 - 2027 Structural profiling of fungal cell wall polysaccharides using functionally modified glycoside hydrolase
2021 - 2026 Application of drug discovery based on immunoreceptor-mediated regulation of osteoclastogenesis by glucan
2021 - 2024 スギ花粉β-グルカンの免疫学的緒活性とアレルギー疾患との関連性に関する研究
2018 - 2021 スギ花粉多糖成分によるアジュバント活性の解析
2018 - 2021 スギ花粉内在性免疫アジュバントの解析
2011 - 2014 The synthesis of biologically active oligosaccharides in symbiosis and immunity
2010 - 2012 Characterization of immunotoxicological and immunopathological roles of fungal PAMPs
2010 - 2012 Examination of rapid and easy detection methods for fungal beta-glucans
2007 - 2009 Characterization of dermal allergic murine models induce by repeated application of non protein substance from pathogenic fungi.
2007 - 2009 真菌PAMPsによる消化管粘膜バリア機能の損傷機構に関する研究
2003 - 2005 The mechanism of liver dysfunction in endogenous septic shock model mice
2000 - 2001 細胞内NADPHの蛍光振幅変化を指標にした白血球の活性化機構の解析
1998 - 1999 Study on regulation of inflammatory response by new mooclonal antibody against leukocytes.
β-D-グルカンの免疫薬理効果に関する研究
Study on immunopharmacological effect of β-D-glucans
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Papers (219)：
Rui Tada, Yuzuho Nagai, Miki Ogasawara, Momoko Saito, Akihiro Ohshima, Daisuke Yamanaka, Jun Kunisawa, Yoshiyuki Adachi, Yoichi Negishi. Polymeric Caffeic Acid Acts as an Antigen Delivery Carrier for Mucosal Vaccine Formulation by Forming a Complex with an Antigenic Protein. Vaccines. 2024. 12. 5. 449-449
Takanori Kawano, Atsushi Miura, Junko Naito, Norihisa Nishida, Ken-ichi Ishibashi, Yoshiyuki Adachi, Naohito Ohno, Yuji Naito. High-parameter immune profiling and subjective health assessment of the immunomodulatory effects of paramylon-rich Euglena gracilis EOD-1: A randomized, double-blind, placebo-controlled, parallel-group study. Journal of Functional Foods. 2023. 109. 105804-105804
Rui Tada, Naohito Ohno, Yoshiyuki Adachi. Refinement and complete solution NMR analysis of the structure of a 6-branched 1,3-β-D-glucan (OL-2) isolate from Omphalia lapidescens. Carbohydrate Research. 2023. 108849-108849
Ce Tang, Haiyang Sun, Motohiko Kadoki, Wei Han, Xiaoqi Ye, Yulia Makusheva, Jianping Deng, Bingbing Feng, Ding Qiu, Ying Tan, et al. Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression. Nature communications. 2023. 14. 1. 1493-1493
菅野峻史, 山口明莉, 平塚理恵, 岩倉洋一郎, 山中大輔, 安達禎之. Comparison of various pollen species in Dectin-1 dependent immune activation. 日本生体防御学会学術総会講演抄録集. 2022. 33rd
山中大輔, 栗田涼香, 菅野峻史, 安達禎之. Development of novel structure-specific detection method for β-1,3/1,6-glucan using split-NanoLuc-fused β-glucan binding proteins. 日本薬学会年会要旨集(Web). 2022. 142nd
滝田峻也, 菅野峻史, 山中大輔, 安達禎之. Comparison of mouse strains in the reactivity to β-1,3-D-glucan in Cryptomeria japonica pollen. 日本薬学会年会要旨集(Web). 2022. 142nd
European Academy of Allergy and Clinical Immunology
, Japanese Society of Allergology
, Japanese Society for Bacteriology
, 国際エンドトキシン自然免疫学会(International Endotoxin and Innate Immunity Society)
, 日本エンドトキシン研究会
, 日本医真菌学会
, 米国免疫学会(AMERICAN ASSOCIATION of IMMUNOLOGIST)
, 日本生体防御学会
, 日本生化学会
, 日本糖質学会
, 日本農芸化学会
, 日本癌学会
, 日本免疫学会
, 日本薬学会
