Udagawa Nobuyuki

2020 - 2023 Elucidation of unknown network mechanism of osteoprotegerin in bone, cardiovascular and digestive system

2019 - 2023 Exploration of druggable targets for metabolic bone diseases using sensitive reporter systems and integrative proteogenomic approaches

2019 - 2023 Development of a revolutionary bone anabolic reagent by optimizing the RANKL reverse signaling to stimulate bone formation.

2019 - 2022 Development of bone anabolic drugs via evaluation of Wnt activity

2019 - 2022 Elucidation of the role of sclerostin in growth and development process of bone

2017 - 2022 Development of bioactive nanocarbon composite that enables spatial and temporal of the metastatic bone cancer environment and biosafety assessments

2018 - 2021 ロイコトキシン-受容体相互作用に関する分子基盤の解明と新規歯周炎ワクチンの開発

2018 - 2021 Development of the new periodontal treatments based on the regulation of sclerostin secretion

2018 - 2021 Elucidation of molecular basis for the relationship between periodontal disease and atherosclerosis by controlling aging

2017 - 2020 Analysis and clinical application of new function of osteoprotegerin as anti-aging factor

2017 - 2020 Analysis of reparative dentin formation regulated by dental pulp stem cells using a fate mapping approach

2017 - 2020 Tissue-resident macrophages in dental pulp regulate the microenvironment for reparative dentine formation

2016 - 2019 Elucidation of the osteoclast-derived cytokine-Wnt signaling network responsible for coupling between bone resorption and formation.

2016 - 2019 Applied research of periodontal disease therapeutics using osteogenic sugnal from osteoclasts

2016 - 2019 Roles of an atypical Wnt receptor, Ryk, for bone formation and mineral metabolism

2016 - 2019 Bone metabolism improving action of plant-derived low molecular weight polyphenols.

2015 - 2018 Bacteriological and immunological analysis for the regulatory factors of aggressive periodontitis in Morocco

2015 - 2018 A study on the usefulness of human dental pulp cells in hard tissue regeneration

2015 - 2018 Attempt of bone regeneration by RANK peptide using alveolar bone resorption model

2016 - 2018 Roles of an atypical Wnt receptor, Ryk, for bone remodeling(Fostering Joint International Research)

2015 - 2017 Did calcitonine appear as a central nerve hormone?

2014 - 2017 Roles of osteoprotegerin in the development of heart failure/aortic aneurysm

2012 - 2017 Establishment and safety evaluation of carbon nanotube (CNT) bio-interface technology for developing high-function biomaterials using CNTs

2014 - 2016 How is the formation site of osteoclasts determined?

2013 - 2016 Elucidation of Wnt signaling network controlling bone metabolism

2013 - 2016 Development of a new drug candidate to stimulate bone formation by oligomerization of RANKL-binding peptides

2013 - 2016 Roles of an atypical Wnt receptor, Ryk, for bone remodeling

2013 - 2016 Development of the artificial bone having a living body resemblance trabecula structure with nanoapatite and the nanocollagen

2013 - 2015 Exploration of seeds for development of a new drug targeting Bone-Vascular-Spleen axis

2012 - 2015 Analysis of bone remodeling mechanism between osteoblasts and osteoclasts for the alveolar bone regeneration

2012 - 2015 Molecular analysis for the calcification mechanism using dental pulp cells

2012 - 2015 Production of the inflammatory periodontal disease model by the enhanced MAPK signaling

2011 - 2013 Basic research about bone regeneration and oral implant for craniofacial defect patients

2010 - 2012 Analysis of osteoclast niche regulated by Wnt signals.

2010 - 2011 Role of Wnt-Ror2 signals in ruffled border formation in osteoclasts

2009 - 2011 Cellular mechanism of maintaining bone minerals by osteocyte lacunar-canalicular system

2009 - 2011 Basic research on development of new treatment of alveolar bone regeneration

2009 - 2011 Elucidation of calcified tissue regeneration mechanism using dental pulp cells

2009 - 2011 Basic research on bone regenerative medicine using dental pulp cells and periodontal ligament cells

2009 - 2010 LPSシグナルを用いた口腔粘膜疾患モデルの開発

2008 - 2010 Analysis of molecular mechanism of carbon nanotube regulating bone metabolism

2008 - 2010 Development of methodology for the hard tissue regeneration using dental pulp cells

2008 - 2009 破骨細胞が分泌する新規骨形成誘導因子の同定

2007 - 2008 Elucidation of the regulated mechanism of bone metabolism by osteoclastic transcytosis.

2007 - 2008 Elucidation of the mechanism of new retinoid X receptor ligand action in the enhancement of bone volume in vivo.

2007 - 2008 骨吸収抑制因子としてのプロスタグランジンE2の作用解析

2006 - 2008 Elucidation of the mechanism of enhancement of ectopic bone formation in osteopetrotic mice.

2006 - 2007 The elucidation of salivary histatin, in correlation with survival and reproduction of oral cells, and Toll-like receptor signals

2006 - 2007 Docetaxel inhibits bone resorption through suppression of osteoclast formation and fuction in different manners

2006 - 2007 転写因子AP-1やNF-κBと協奏的に働く破骨細胞の分化因子のクローニング

2005 - 2007 Analysis of the Nod signals which enhance bone resorption

2005 - 2006 Establishment of periodontitis treatment method by inhibition of RANK-Toll like receptor signal

2005 - 2006 Research on tissues and cell types-specific expression of the histatin 3 gene implicated in innate immune system

2005 - 2006 Analysis of p38 MAP kinase pathway in osteoclasts

2005 - 2006 Elucidation of molecular mechanism of alveolar bone remodeling induced by orthodontic force.

2004 - 2005 Elucidation of receptors for salivary protein histatin in human gingival fibroblast

2004 - 2005 破骨細胞によるビスフォスホネートの特異的取り込み機構の解析

2003 - 2004 Signal transduction of RANK and Toll-like receptor in alveolar bone destruction

2003 - 2004 Determination of Cementum Specific Proteins in Horse Molar Teeth

2003 - 2004 The possible mechanism of alveolar bone destruction induced by constituent of gram-negative bacteria.

2003 - 2004 Analysis of tooth development of osteoprotegerin- deficient mice

2003 - 2004 破骨細胞分化阻止因子(ODIF)のクローニングと生理的役割の解析

2002 - 2004 Analysis of molecular mechanisms in bone formation and regeneration

2000 - 2004 破骨細胞を調節するシグナル伝達系と骨・歯周疾患における骨破壊機序の解明

2002 - 2003 Signal transduction and cell-to-cell communication in the bone resorption induced by inflammation

2001 - 2003 Study on mechanism of the coupling between bone resorption and bone formation

2001 - 2002 骨芽細胞及びリンパ球の分化を促進する破骨細胞由来新規サイトカインの同定

2001 - 2002 Analysis of signal transduction of osteoclast differentiation factor (RANKL) in alveolar bone destruction

2001 - 2002 CHARACTERIZATION OF THE BONE FORMING FACTORS IN SERUM

2000 - 2001 Role of Vitamin D hydroxylase on Bone Metabolism.

2000 - 2001 Analysis of signal transduction of inflammatory cytokines in bone destruction

1999 - 2000 The physiological role of osteoclast differentiation factor.

1999 - 2000 Study on signal transduction in osteoclastogenesis for the development of anti-osteoporosis drugs.

1999 - 2000 破骨細胞の融合機構とその生理的意義の解明

1998 - 1999 The roles of nuclear transcription factors in calcium homeostasis

1998 - 1999 Study on osteoclast activiting factor expressed by osteoblasts/stromal cells

1997 - 1998 Mechanism of osteoclastogenesis inhibitory action by interleukin 18

1997 - 1998 ヒトPTH受容体遺伝子の導入によるヒト破骨細胞形成系の確立

1996 - 1998 Development of bone metabolism improvement medicines based on the analysis of signal transduction

1996 - 1997 Pathogenesis of bone loss due to estrogen deficiency : Relationship between increased B-lymphopoiesis and bone resorption.

1996 - 1997 Regulation of PGE synthesis by activated cytosolic phospholipase A2 and induced cyclooxygenase-2 in osteoblasts.

1995 - 1997 Establishment of assay systems for examining bone metabolism : Studies on differentiation and function of osteoblasts and osteoclasts

1995 - 1996 Analysis of gp130-induced signals which regulate osteclast formation and function

1994 - 1995 Molecular mechanisms of osteoporosis induced by estrogen deficiency.

1994 - 1995 Role of vitamin D and parathyroid hormone on vitamin D metabolism in the kidney.

1993 - 1995 Development of reliable screening systems for drugs which regulate bone resorption : In vitro assay systems for osteoclast formation and function.

1994 - 1994 破骨細胞形成におけるインターロイキン6の役割の解明

1993 - 1994 Analysis of signaling pathways involved in polarization of osteoclasts.

1993 - 1993 大理石骨病モデルマウスを用いた破骨細胞の骨吸収機構の解析

1992 - 1993 Molecular aspects of vitamin D metabolism and action

破骨細胞が産生する骨芽細胞分化誘導因子の同定

破骨細胞の骨吸収のメカニズムに関する研究

破骨細胞の分化・形成に関する研究

Identification of osteoblast differentiation factor produced by osteoclasts

Study on mechanism of bone resorption in osteoclasts

Study on osteoclast differentiation