Research field (3)：
Structural biochemistry
, Biophysics
, Functional biochemistry
Research keywords (13)：
てんかんモデルラット
, 蛋白質の安定化・凝集防止
, 細胞内情報伝達
, NMR
, ペプチド
, 蛋白質
, spontaneous epileptic rat
, prevention of protein aggregation
, stabilization of proteins
, signal transduction
, NMR
, peptide
, protein
Research theme for competitive and other funds (15)：
2017 - 2020 Structural analysis of the interaction between spinophilin, a GPCR-signaling modulator, with GPCR
2012 - 2016 Stabilization of drug-target proteins by sulfobetaines
2009 - 2011 Mechanism analysis of sulfobetaines' activity to prevent protein aggregation and application of sulfobetaines to unstable proteins
2007 - 2008 膜蛋白質の構造解析を推進する試薬の開発
2005 - 2007 Fabrication of Microchips Made of Low-RI Fluorinated Polymers and Their Application to μ-TAS
2005 - 2006 蛋白質の凝集を防止する低分子化合物の構造解析への応用と新規合成
2005 - 2006 膜蛋白質の構造解析を推進する試薬の開発
2001 - 2002 膜環境下で形成される異種生体防御ペプチド間の希少高活性超分子
2001 - 2001 部分ペプチドを用いた蛋白質・蛋白質相互作用の解析
2000 - 2000 部分ペプチドを用いた蛋白質・蛋白質相互作用の解析
1999 - 1999 部分ペプチドを用いた蛋白質・蛋白質相互作用の解析
1998 - 1998 部分ペプチドを用いた蛋白質・蛋白質相互作用の解析
1997 - 1998 Mechanism of G protein alpha subunit activation by receptors
1994 - 1996 Analysis of Receptor-G Protein Interactions by using Receptor Peptide Fragments
1991 - 1992 Regulation of G proteins by Receptor-Mimetic Peptides
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Papers (74)：
Hideki Kusunoki, Taiichi Sakamoto, Naohiro Kobayashi, Toshiyuki Kohno, Kaori Wakamatsu, Takashi Nagata. Structural insights into the interaction between the C-terminal-deleted BH3-like motif peptide of hepatitis B virus X protein and Bcl-xL. Biochemistry. 2024. 63. 632-643
Hideki Kusunoki, Toshiyuki Tanaka, Chinatsu Ohshima, Taiichi Sakamoto, Kaori Wakamatsu, Isao Hamaguchi. The N93D mutation of the human T-cell leukemia virus type 1 envelope glycoprotein found in symptomatic patients enhances neuropilin-1 b1 domain binding. Biochimica et Biophysica Acta - Proteins and Proteomics. 2021. 1869. 11
Yuriko Atsumi, Natsuko Sakurai, Koichiro Nishimura, Katsuyoshi Yamazaki, Kaori Wakamatsu. Identification and characterization of a monoclonal antibody variant species with a clipping in the complementarity determining region isolated by size exclusion chromatography under native conditions. Journal of pharmaceutical sciences. 2021
葛貫絵梨奈, 毒島いぶき, 黒川優香, 浦野智子, 島崎安希子, 河野俊之, 細田和男, 寺脇慎一, 若松馨. Interaction of a novel fusion protein between the adrenergic receptor intracellular third loop and the GPCR modulator Spinophilin. Abstracts. Annual Meeting of the NMR Society of Japan. 2020. 59th
黒川優香, 葛貫絵梨奈, 日比健人, 河野俊之, 寺脇慎一, 若松馨. Prevention of aggregation of proteins and peptides with amyloid tendency. Abstracts. Annual Meeting of the NMR Society of Japan. 2020. 59th
黒川優香, 葛貫絵梨奈, 浦野智子, 島崎安希子, 河野俊之, 細田和男, 寺脇慎一, 若松馨. アドレナリン受容体細胞内第三ループとGPCRモジュレーターSpinophilinとの相互作用解析. Abstracts. Annual Meeting of the NMR Society of Japan. 2019. 58th (CD-ROM)
楠英樹, 田中俊之, 河野俊之, 細田和男, 若松馨, 浜口功. 受容体ニューロピリン1に結合する新規HTLV-1外被糖蛋白質配列の同定. Abstracts. Annual Meeting of the NMR Society of Japan. 2018. 57th
Interaction of BH3-like motif of hepatitis B virus X protein with anti-apoptotic protein Bcl-xL
(27th International Council on Magnetic Resonance in Biological Systems (ICMRBS) 2016)
Interaction of BH3-like motif of hepatitis B virus X protein with anti-apoptotic protein Bcl-xL
(27th International Council on Magnetic Resonance in Biological Systems (ICMRBS) 2016)
- 1986 The University of Tokyo Graduate School, Division of Science
- 1983 The University of Tokyo
- 1983 The University of Tokyo Graduate School, Division of Science
- 1981 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
- 1981 The University of Tokyo Faculty of Science
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Professional career (1)：
1H-NMR Analyses of the Interaction of Peptides with Phospholipid Bilayer: Relationships between Interaction and Physiological Activity (The University of Tokyo)
