- 2022 - 2025 ネクロプトーシス実行因子MLKLを標的とした心不全治療の開発
- 2021 - 2024 AMPデアミナーゼ活性制御機構の解明と糖尿病性心筋症治療への応用
- 2021 - 2024 Intracellular signal transduction regulating necroptosis of cardiomyocytes
- 2021 - 2024 Role of non-classical renin-angiotensin system in contrast induced nephropathy
- 2019 - 2022 Necroptosis-tartgeted therapy for heart failure
- 2018 - 2021 Cross-talk of cardiomyocyte necroptosis and autophagy in heart failure
- 2017 - 2020 Development of novel therapeutic approach for diabetic cardiomyopathy by modification of AMP deaminase activity.
- 2016 - 2019 The role of aberrant mTOR activation in heart failure
- 2014 - 2017 Role of mitochondrial permeability transition in necroptosis of the cardiomyocyte
- 2014 - 2017 Novel therapeutic approach for heart failure by suppression of mitochondrial translocation of GSK-3beta
- 2011 - 2013 Protein kinases regulating the mitochondrial permeability transition pore
- 2011 - 2013 Novel therapeutic approach for heart failure by promoting nuclear translocation of SIRT1, a protein deacetylase
- 2008 - 2010 Role of connexin-43 in protective signaling incardiomyocyte
- 2008 - 2010 Clarification of mechanisms to regulate the activity of protein deacetylase SIRT1 and its therapeutic application in heart failure
- 2006 - 2007 ヒストン脱アセチル化酵素SIRT1の細胞内局在の調節と心不全治療への応用
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