Rchr
J-GLOBAL ID：200901077835231225   Update date: Feb. 22, 2024

Takai Toshiyuki

タカイ トシユキ | Takai Toshiyuki
Affiliation and department：
Tohoku University Institute of Development, Aging and Cancer Division of Gene Research Experimental Immunology

About Tohoku University Institute of Development, Aging and Cancer Division of Gene Research Experimental Immunology


Job title： Specially Appointed Professor (Research)
Research field  (2)： Immunology ,  Medical biochemistry
Research keywords  (11)： Immune checkpoint ,  Inhibitory receptor ,  Immunotherapy ,  Immunoregulation ,  Fc receptor ,  LILRB ,  Fc受容体 ,  免疫療法 ,  免疫制御 ,  抑制受容体 ,  immunoglobulin-like receptor
Research theme for competitive and other funds  (31)：
  • 2019 - 2022 Mechanism of LILRB4-mediated immune checkpoint
  • 2017 - 2020 Modulating immunological memory of antibody-producing cells
  • 2016 - 2019 Identification of molecular characteristics of pathogenic autoantibody-producing cells
  • 2014 - 2017 The role of immunosuppressive receptor LILRB in the pathogenesis of Kawasaki disease, and its application to the therapy.
  • 2014 - 2016 Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcg receptors.
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Papers (273)：
  • Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, et al. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. Journal of Experimental Medicine. 2023. 220. 9
  • Sakiko Kumata, Hirotsugu Notsuda, Mei-Tzu Su, Ryoko Saito-Koyama, Ryota Tanaka, Yuyo Suzuki, Junichi Funahashi, Shota Endo, Isao Yokota, Toshiyuki Takai, et al. Prognostic impact of LILRB4 expression on tumor-infiltrating cells in resected non-small cell lung cancer. Thoracic Cancer. 2023
  • Fumika Itagaki, Keita Nakatsuka, Haruka Sakai, Shota Endo, Mei-Tzu Su, Toshiyuki Takai. Fibronectin on target cells attenuates natural cytotoxicity of NK cells via myeloid immune checkpoint ILT3/LILRB4/gp49B. International Immunology. 2023. 35. 7. 339-348
  • Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, et al. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. 2023. 26. 4. 106375-106375
  • Shotaro Miyamoto, Takumi Chiba, So Itoi, Mei-Tzu Su, Toshiyuki Takai. LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells. The Tohoku Journal of Experimental Medicine. 2023. 259. 4. 273-284
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MISC (127)：
  • NISHIMURA Hiroyuki, IIDA Noriko, OHTSUJI Mareki, KODERA Yo, TAKAI Toshiyuki, SUDO Katsuko, VERBEEK Sjef, HIROSE Sachiko. Roles of inhibitory Fc receptor FcgammaRIIB on the peripheral B cell tolerance. 日本免疫学会総会・学術集会記録(CD-ROM). 2021. 50
  • 遠藤 章太, 蘇 美慈, 高井 俊行. Fcγレセプター,抑制性レセプター. 臨床免疫・アレルギー科. 2020. 73. 1. 43-50
  • Endo S, Su MT, Takai T. Immune regulation by PirB/LILRB2 and gp49B/LILRB4. Seitai no Kagaku. 2019. 70. 3. 223-229
  • NISHIMURA Hiroyuki, IIDA Noriko, OHTSUJI Mareki, KODERA Yo, TAKAI Toshiyuki, SUDO Katsuko, VERBEEK Sjef J, HIROSE Sachiko. Epistatic interaction between Fcgr2b and Slam family genes in susceptibility to the defective peripheral immune tolerance and autoimmunity. 日本免疫学会総会・学術集会記録(CD-ROM). 2019. 48
  • NISHIMURA Hiroyuki, OBATA Masaomi, OHTSUJI Mareki, KODERA Yo, TAKAI Toshiyuki, SUDO Katsuko, VERBEEK J. Sjef, HIROSE Sachiko. Epistatic interaction between fcgr2b and Slam family genes in susceptibility to defective foreign protein-induced tolerance. 日本免疫学会総会・学術集会記録(CD-ROM). 2018. 47
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Patents (19)：
  • IMMUNE CHECKPOINT INHIBITOR
  • 炎症性疾患のマーカー
  • リウマチ関節炎高発症モデルマウス
  • 大理石骨病モデル非ヒト動物
  • 移植片対宿主病モデル動物
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Lectures and oral presentations  (141)：
  • Immunoreceptors Regulating Autoantibody Production in Aging.
    (Tohoku Forum for Creativity Thematic Program 2017 Aging Science: from Molecules to Society 2017)
  • 免疫制御と疾患におけるIgGとFcレセプター.
    (第3回FcR研究フォーラム2017 2017)
  • Regulatory receptor LILRB4 characterizes pathogenic plasma cells in SLE.
    (11th International Symposium of The Institute Network “Frontiers in Biomedical Sciences” 2017)
  • 免疫制御と疾患におけるIgGとFcレセプター.
    (Fc Summit 2016)
  • 川崎病患者に対する免疫グロブリン大量療法前後における抑制性受容体LILRB発現の変化について.
    (日本川崎病学会 2016)
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Education (2)：
  • - 1986 Kyoto University Graduate School, Division of Medicine 生理系
  • - 1980 Okayama University Faculty of Pharmaceutical Science 製薬化学
Professional career (1)：
  • 医学博士 (Kyoto University)
Work history (1)：
  • 2023/04 - 現在 Tohoku University Institute of Development, Aging and Cancer Division of Gene Research Experimental Immunology Specially Appointed Professor (Research)
Committee career (8)：
  • 2008/10 - 現在 日本免疫学会 評議員
  • 2002/04 - 現在 International Immunology 編集委員
  • 2002/04 - 現在 International Immunology 編集委員
  • 1998/04 - 2021/03 日本生化学会 評議員
  • 2016/10 - 2018/09 日本免疫学会 理事
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Awards (3)：
  • 2012/04 - 文部科学省 科学技術分野の文部科学大臣表彰 科学技術賞 研究部門 「免疫制御Fc受容体の研究」
  • 2004/12 - 日本免疫学会 平成16年度免疫学会賞 「イムノグロブリン様受容体による免疫制御と免疫疾患に関する研究」
  • 1994/07 - 岡山工学振興会 岡山工学振興会科学技術賞 「遺伝子ノックアウトを用いたマウス局所免疫系におけるFc受容体の機能解析」
Association Membership(s) (14)：
日本生化学会(1998/04- 評議員) ,  日本免疫学会(2008/10- 評議員) ,  日本学術振興会(2005/04-2007/03 専門委員) ,  Europeal Journal Immunology(2001/04- 編集委員) ,  International Immunology(2002/04- 編集委員) ,  Springer Seminars in Immunopathology(2007/04- 顧問) ,  東北医学会(1998/04-1999/03 評議員) ,  免疫と疾患研究会(1998/04- 世話人) ,  東北免疫研究会(1999/04- 顧問) ,  American Association of Immunologists(1993/04-) ,  日本再生医学会(1995/04-) ,  日本アレルギー学会(1995/04-) ,  日本分子生物学会(1993/04-) ,  日本免疫学会(1993/04-)
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