Tamura Osamu

タムラオサム | Tamura Osamu

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.shoyaku.ac.jp/labosite/yakka/index.html

Research field (4)： Pharmaceuticals - chemistry and drug development , Synthetic organic chemistry , Bioorganic chemistry , Structural/physical organic chemistry

Research keywords (2)：有機化学医薬品化学有機合成化学 , Organic Chemistry Medicinal Chemistry

Research theme for competitive and other funds (26)：

2020 - 2023 Cope型ヒドロアミノ化に基礎をおくケミカルバイオロジー・創薬基盤技術の開発
2017 - 2020 Development of reactions by means of novel activation of oximes
2013 - 2016 Sophisticated utilization of oximes in construction of nitrogen-containing carbon-frameworks
2010 - 2012 DEVELOPMENT OF NOVEL NITROGEN-CONTAINING 1,3-DIPOLARS
2007 - 2009 CONSTRUCTION OF POLYCYCLIC SYSTEMS USING OXIDATION OF AROMATIC COMPOUNDS

2006 - 2007 機能性ニトロンを用いる含窒素生理活性物質の合成研究

2004 - 2006 Deve I opment of Practical Radical Reaction and its Applicat i on to the Synthesis of Physiologically Active Compounds

2005 - 2005 機能性ニトロンを用いる含窒素生理活性物質の合成細胞

2003 - 2004 Synthetk Studies on Multi Sorts of Biologically Active Cormpounds Using Nitrones Related to Amino Acids and Sugars

2002 - 2004 パーフルオロアルキル置換オレフィン類の新合成法の開発とその応用

2001 - 2003 Synthesis of Biologically Active Compounds Using Radical Cyclization Based on New Methodologies

1999 - 2001 Synthetic study on nikkomycins using addition reactions of nitrones

1999 - 2000 Synthesis of Biologically Active Compounds Based on the Regio- and Stereo-Controlled Radical Cyclizations

1995 - 1995 双極子付加反応を用いる光学活性γ-ヒドロキシ-α-アミノ酸関連化合物の合成研究

1994 - 1994 α-アルコキシカルボニルニトロンの幾何構造を制御または固定した双極子付加反応

1993 - 1993 不斉1,3-双極子付加を用いる光学活性をインドリチジン、キノリチジン類の合成研究

機能性有機分子の製造研究

医薬に重要な化合物の製造研究

含フッ素化合物の新合成法

新しい環化付加反応の開発

立体選択的な骨格構築法の開発とその天然物合成等への応用

Process Research of Functional Organic Molecules

Process Research of Medicinally Important Compounds

New Synthetic Method of Fluorine-containing Compounds

Development of a Novel Cycloaddition Reaction

Stereoselective Construction of Nitrogen Containing Carbonframeworks and Its Application

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Papers (79)：

Yosuke Ide, Naoto Matsuda, Mei Osada, Ayaka Yamamoto, Kosaku Tanaka, Yoshimitsu Hashimoto, Nobuyoshi Morita, Osamu Tamura. Hetero Cope-Type Hydroamination of Hetero-Allenes with Oximes Having Olefin Moieties Leading to Nitrones, Causing Intramolecular Cycloaddition. The Journal of Organic Chemistry. 2024. 89. 18. 12973-12981
Ayaka Yamamoto, Kosaku Tanaka, III, Yoshimitsu Hashimoto, Nobuyoshi Morita, Osamu Tamura. Intermolecular 1,3-Dipolar Cycloaddition Reaction of N-Carbamoyl Nitrones Generated by N-Selective Carbamoylation of Oximes with Isocyanates. Chemistry - A European Journal. 2024
Nobuyoshi Morita, Shingo Uchida, Hitomi Chiaki, Naho Ishii, Kentaro Tanikawa, Kosaku Tanaka, Yoshimitsu Hashimoto, Osamu Tamura. Gold(III)-Catalyzed Propargylic Substitution Reaction Followed by Cycloisomerization for Synthesis of Poly-Substituted Furans from N-Tosylpropargyl Amines with 1,3-Dicarbonyl Compounds. Molecules. 2024. 29. 2. 378-378
Hiroto Sagara, Yoshio Suzuki, Nobuyoshi Morita, Shintaro Ban, Kosaku Tanaka, Ayaka Yamamoto, Yoshimitsu Hashimoto, Osamu Tamura. Direct Generation of <i>N</i>-Alkoxycarbonyl Nitrones from Oximes: Intramolecular Cycloaddition of Oximes Having Alkene Moieties. Advanced Synthesis & Catalysis. 2023
Kosaku Tanaka, Mayumi Yoshida, Ayaka Yamamoto, Yoshimitsu Hashimoto, Nobuyoshi Morita, Osamu Tamura. Synthesis of N-Aryl Isoxazolidines by Photo-Promoted N-Selective Arylation of Oximes and Cyclization Using Hypervalent Iodine Reagents and Copper Catalyst. Advanced Synthesis and Catalysis. 2023. 365. 9. 1419-1424

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MISC (145)：

千秋妃美, 石井奈穂, 森田延嘉, 橋本善光, 田村修. Gold-Catalyzed Synthesis of Cyclobutanes. 日本薬学会年会要旨集(Web). 2024. 144th
本田侑基, 単智博, 山本彩可, 橋本善光, 田中耕作三世, 森田延嘉, 田村修. Kharasch addition to α,β-unsaturated oximes. 日本薬学会年会要旨集(Web). 2024. 144th
梅沢孝仁, 森田延嘉, 千秋妃美, 橋本善光, 田村修. Gold-catalyzed Synthesis of Poly-Substituted Pyrroles. 日本薬学会年会要旨集(Web). 2024. 144th
山本彩可, 胡内達也, 齊藤陸, 田中耕作三世, 橋本善光, 森田延嘉, 田村修. Three-component coupling reaction by direct generation of nitrones and its application. 日本薬学会年会要旨集(Web). 2024. 144th
橋本善光, 吉田究, 古郡美優, 吉野徹, 田中耕作三世, 森田延嘉, 田村修. Electrophilic epoxidation of α,β-unsaturated oximes and following ring-opening. 日本薬学会年会要旨集(Web). 2024. 144th

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Works (2)：

DNAと相互作用する環状ペプチドの合成研究
1997 - 1999
Synthetic Studies of Peptides interactive with DNA
1997 - 1999

Education (4)：

- 1988 Osaka University
- 1988 Meiji Pharmaceutical University Faculty of Pharmaceutical Sciences
- 1988 Osaka University
- 1982 Meiji Pharmaceutical University Faculty of Pharmacy Department of Medicinal Chemistry

Professional career (1)：

(BLANK)

Committee career (1)：

2008/04 - 2011/03 日本薬学会ファルマシア委員

Awards (1)：

1996 - 有機合成化学奨励賞

Association Membership(s) (3)：

有機合成化学協会 , 日本化学会 , 日本薬学会

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