Yamagata Yoko

ヤマガタヨウコ | Yamagata Yoko

Affiliation and department：
Job title： Assistant Professor
Other affiliations (1)：

SOKENDAI (The Graduate University for Advanced Studies) Assistant Professor

Homepage URL (2)： https://www.nips.ac.jp/research/group/post-59/ , https://www.nips.ac.jp/eng/research/group/post-59/

Research field (3)： Clinical pharmacy , Physiology , Neuroscience - general

Research keywords (17)：包括脳ネットワーク , 生理学 , 生体分子 , カルモジュリンキナーゼII , シナプス可塑性 , キンドリング , シナプシンI , 脳・神経 , 神経科学 , 遺伝子変異動物 , 蛋白質リン酸化 , 学習・記憶 , 急性神経活動 , シグナル伝達 , 海馬 , タンパク質リン酸化 , Ca^<2+>

Research theme for competitive and other funds (10)：

2019 - 2022 A mechanism for the decline of memory with aging.
2016 - 2019 Exploration of substrate proteins of calmodulin kinase II by using the kinase-dead knock-in mouse.
2010 - 2012 The role of calmodulin-kinase II in the mechanism of amygdala-dependent learning and memory.
2005 - 2006 Regulation of brain functions by Ca^<2+>/calmodulin-dependent protein kinase II activity
1998 - 2000 Functional analysis of Ca^<2+>/calmodulin-dependent protein kinase II using genetically engineered animals.

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Papers (13)：

Yamagata Y, Yanagawa Y, Imoto K. Differential Involvement of Kinase Activity of Ca²⁺/Calmodulin-Dependent Protein Kinase IIα in Hippocampus- and Amygdala-Dependent Memory Revealed by Kinase-Dead Knock-In Mouse. eNeuro. 2018. 5. 4
Solveigh Cornelia Koeberle, Shinji Tanaka, Toshihiko Kuriu, Hirohide Iwasaki, Andreas Koeberle, Alexander Schulz, Dario-Lucas Helbing, Yoko Yamagata, Helen Morrison, Shigeo Okabe. Developmental stage-dependent regulation of spine formation by calcium-calmodulin-dependent protein kinase II alpha and Rap1. SCIENTIFIC REPORTS. 2017. 7. 1. 13409
Yoko Yamagata, Angus C. Nairn. Contrasting features of ERK1/2 activity and synapsin I phosphorylation at the ERK1/2-dependent site in the rat brain in status epilepticus induced by kainic acid in vivo. BRAIN RESEARCH. 2015. 1625. 314-323
Naohiro Kon, Tomoko Yoshikawa, Sato Honma, Yoko Yamagata, Hikari Yoshitane, Kimiko Shimizu, Yasunori Sugiyama, Chihiro Hara, Isamu Kameshita, Ken-ichi Honma, et al. CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms. GENES & DEVELOPMENT. 2014. 28. 10. 1101-1110
Yoko Yamagata, Koichi Kaneko, Daisuke Kase, Hiromi Ishihara, Angus C. Nairn, Kunihiko Obata, Keiji Imoto. Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices. BRAIN RESEARCH. 2013. 1507. 1-10

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MISC (20)：

金尚宏, 吉川朋子, 本間さと, 山肩葉子, 吉種光, 清水貴美子, 杉山康憲, 原千尋, 亀下勇, 本間研一, et al. 行動・睡眠リズムを支配する体内時計の分子機構とその創薬標的としての可能性概日時計システムにおけるCaMKIIの役割. 日本生化学会大会プログラム・講演要旨集. 2014. 87回. [4S08a-4]
山肩葉子. シナプシン. 脳科学辞典. 2014
金尚宏, 吉川朋子, 本間さと, 山肩葉子, 吉種光, 清水貴美子, 杉山康憲, 原千尋, 亀下勇, 本間研一, et al. 概日時計システムにおけるCaMKIIの役割. 日本生化学会大会(Web). 2014. 87th. 4S08A-4 (WEB ONLY)
山肩葉子, 井本敬二. 大脳・小脳での可塑性の意義長期記憶の分子機構. Clin Neurosci. 2011. 29. 7. 777-781
Yoko Yamagata, Yuchio Yanagawa, Keiji Imoto. Contribution of kinase activity of Ca2+/calmodulin-dependent protein kinase II alpha to hippocampus- and amygdala-dependent memory formation. NEUROSCIENCE RESEARCH. 2011. 71. E181-E181

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Patents (1)：

不活性型Ca2+/カルモジュリン依存性プロテインキナーゼIIαノックイン動物および同ノックイン細胞

Books (1)：

Ca┣D12+┫D1/calmodulin-dependent protein kinase II. In : Human Protein Data (A. Haeborli, ed), 2nd Installment.
Human Protein Data (A. Haeborli, ed), 2nd Installment. (VCH Weinheim) 1993

Professional career (2)：

MD (Kyoto University Faculty of Medicine)
PhD (Kyoto University Faculty of Medicine)

Association Membership(s) (6)：

THE JAPANESE SOCIETY OF INTERNAL MEDICINE , Society for Neuroscience , THE JAPANESE BIOCHEMICAL SOCIETY , PHYSIOLOGICAL SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE JAPAN NEUROSCIENCE SOCIETY

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