Rchr
J-GLOBAL ID：200901078764083099
Update date: Feb. 10, 2024
Ayako Wakabayashi
ワカバヤシ アヤコ | Ayako Wakabayashi
Affiliation and department：
Job title：
Senior Assistant Professor
Research field (1)：
Immunology
Research keywords (5)：
Immunology
, Mucosal Immunology
, allergy
, gut microbiome
, Food Hygiene
Research theme for competitive and other funds (17)：
- 2022 - 2026 Analysis of intestinal bacterial invasion into intestinal epithelial cells and inflammation induction by an aluminum-containing food additive alum
- 2021 - 2024 イヌの肝細胞癌のオルガノイドバンクの構築および新規治療法の開発
- 2023 - 2023 A food additive containing aluminum causes cleavage of interleukin-33 and gasdermin D in intestinal epithelial cells under antibiotic treatment
- 2019 - 2023 好酸球性副鼻腔炎病態への腸内フローラ、カンジダ増殖関与についての予備的研究
- 2021 - 2023 抗生剤が促進する食品添加物ミョウバンによる腸管上皮の炎症性細胞死の解析
- 2019 - 2023 Release of damage-associated molecular patterns from intestinal epithelia by aluminum salt and involvement in the development of food allergy
- 2017 - 2023 Gut microbiotaの制御が脳虚血病巣進展および神経機能に及ぼす影響
- 2021 - 2022 食品添加物ミョウバン刺激後に腸上皮細胞に侵入して炎症性細胞死を誘導する腸内マイクロバイオームへ抗生剤が与える影響の16S rRNAメタゲノム解析
- 2020 - 2022 腸内細菌叢および腸管上皮細胞からのDAMPs制御による脳虚血病巣進展への影響
- 2019 - 2022 ミョウバンによる腸管上皮損傷に伴う炎症・アレルギー誘導性損傷関連分子の放出の解析と免疫学的安全性評価の検討
- 2020 - 2020 食品添加物ミョウバンによるマウス腸上皮細胞インフラマソーム活性化のトランスクリプトーム解析
- 2015 - 2019 Damage-associated molecular pattern released from intestinal epithelia damaged by bacterial exotoxin induces food allergy
- 2012 - 2015 Activation of dendritic cells and induction of ovalbumin-specific allergic responses by irradiation
- 2009 - 2011 Induction of ovalbumin-specific allergic reaction by ingestion of food additives including aluminum
- 2006 - 2008 Induction of ovalbumin ?specific immune responses by oral administration of residual chlorine : chlorine and food allergy
- 2008 - 経口ワクチンによる抗腫瘍免疫誘導法の研究
- 2002 - 2003 腸内の細菌外毒素が卵白アルブミン特異的免疫反応に与える影響:毒素と食物アレルギー
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Papers (15)：
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Ayako Wakabayashi, Masumi Shimizu, Eiji Shinya, Hidemi Takahashi. HMGB1 released from intestinal epithelia damaged by cholera toxin adjuvant contributes to activation of mucosal dendritic cells and induction of intestinal cytotoxic T lymphocytes and IgA. Cell death & disease. 2018. 9. 6. 631-631
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Ryosuke Murakami, Yohko Nakagawa, Masumi Shimizu, Ayako Wakabayashi, Yasuyuki Negishi, Takachika Hiroi, Kimihiro Okubo, Hidemi Takahashi. Effects of Dendritic Cell Subset Manipulation on Airway Allergy in a Mouse Model. International archives of allergy and immunology. 2015. 168. 4. 219-32
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Hirotomo Harimoto, Masumi Shimizu, Yohko Nakagawa, Katsuhisa Nakatsuka, Ayako Wakabayashi, Choitsu Sakamoto, Hidemi Takahashi. Inactivation of tumor-specific CD8+ CTLs by tumor-infiltrating tolerogenic dendritic cells. Immunology and cell biology. 2013. 91. 9. 545-55
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Yasuyuki Negishi, Ayako Wakabayashi, Masumi Shimizu, Tomoko Ichikawa, Yoshihiro Kumagai, Toshiyuki Takeshita, Hidemi Takahashi. Disruption of maternal immune balance maintained by innate DC subsets results in spontaneous pregnancy loss in mice. Immunobiology. 2012. 217. 10. 951-61
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Keiichi Moriya, Ayako Wakabayashi, Masumi Shimizu, Hideto Tamura, Kazuo Dan, Hidemi Takahashi. Induction of tumor-specific acquired immunity against already established tumors by selective stimulation of innate DEC-205(+) dendritic cells. Cancer immunology, immunotherapy : CII. 2010. 59. 7. 1083-95
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MISC (77)：
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若林あや子. ミョウバンによる腸管上皮損傷に伴う炎症・アレルギー誘導性損傷関連分子の放出の解析と免疫学的安全性評価の検討. 日本食品化学研究振興財団 第28回(令和3年度)研究成果報告書. 2022. 28. 57-62
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若林あや子, 森田林平, 岩槻健, 隈本宗一郎. 食品添加物ミョウバン刺激後に腸上皮細胞に侵入して炎症性細胞死を誘導する腸内マイクロバイオームへ抗生剤が与える影響の16S rRNAメタゲノム解析. 東京農業大学生物資源ゲノム解析拠点ニュースレター. 2022. 9. 33
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若林あや子. Analysis of release of damage-associated molecular patterns involved in inflammation and allergy after intestinal epithelial damage by potassium aluminum sulphate and immunological safety evaluation. 日本食品化学研究振興財団研究成果報告書. 2021. 27. 110-120
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Increased inflammatory cell death in intestinal epithelial cells by oral administration of aluminum salt as a food additive. 2021. 70. 6-7. 742
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若林 あや子, 大脇 敦子, 岩槻 健, 田中 啓介, 長田 康孝, 西山 康裕, 松根 彰志, 森田 林平. アルミニウム含有食品添加物で誘導されるアレルギーと腸管上皮細胞死の解析. 日本栄養・食糧学会大会講演要旨集. 2021. 75回. 124-124
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Lectures and oral presentations (87)：
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An aluminum-containing food additive causes cleavage of IL-18, IL-33 and gasdermin D in intestinal epithelial cells under antibiotic treatment
(The 52nd Annual Meeting of The Japanese Society for Immunology 2024)
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An aluminum-containing food additive causes cleavage of IL-33 and gasdermin D in intestinal epithelial cells under antibiotic-treatment
(The World Allergy Congress (WAC) 2023 2023)
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An aluminum-containing food additive causes pyroptosis and IL-18 production in intestinal epithelial cells under antibiotic treatment
(2023)
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抗生剤が促進する食品添加物ミョウバンによる腸管上皮の炎症性細胞死の解析
(文部科学省科学技術人材育成費補助事業「ダイバーシティ研究環境実現イニシアティブ(牽引型)」 2022年度共同研究・研究支援員配置 研究成果発表会 2023)
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アルミニウム含有食品添加物は腸上皮細胞において細胞死に関わるカスパーゼを活性化する
(第 91 回日本医科大学医学会学術集会 2023)
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Professional career (1)：
- Ph.D (Tokyo Medical and Dental University)
Work history (7)：
- 2016 - 現在 Nippon Medial School Department of Microbiology and Immunology Senior Assistant Professor
- 2001 - 現在 Japan Women’s University Adjunct Asistant Professor
- 2007 - 2016 Nippon Medical School Department of Microbiology and Immunology Assistant Professor
- 1999 - 2007 Nippon Medical School Department of Microbiology and Immunology Research Associate
- 1997 - 1999 Japan Foundation for Aging and Health Research Resident
- Nippon Medical School
- Nippon Medical School Department of Microbiology and Immunology Senior Assistant Professor
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Committee career (2)：
- 2019/04 - 現在 学校法人日本医科大学しあわせキャリア支援センター 委員
- 2015/04 - 2019/03 日本医科大学法人本部女性医師・研究者支援室 室員
Awards (2)：
- 2019/04 - 公益財団法人日本食品化学研究振興財団助成金 ミョウバンによる腸管上皮損傷に伴う炎症・アレルギー誘導性損傷関連分子の放出の解析と免疫学的安全性評価の検討
- 2008 - Nippon Medical School The Award in Maruyama's memory
Association Membership(s) (3)：
JAPANESE SOCIETY OF ALLERGOLOGY
, JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE
, THE JAPANESE SOCIETY FOR IMMUNOLOGY
