Rchr

J-GLOBAL ID：200901078866545712 Update date: Nov. 17, 2024

Ishihara Jun

イシハラジュン | Ishihara Jun

Affiliation and department：
Job title： Professor

Research field (3)： Pharmaceuticals - chemistry and drug development , Bioorganic chemistry , Structural/physical organic chemistry

Research keywords (6)：天然物合成 , 海洋天然物 , 天然物化学 , 有機合成化学 , synthetic chemistry , organic chemistry

Research theme for competitive and other funds (35)：

2021 - 2022 高効率的合成に基づく微少多環性マクロリド天然物の創薬展開
2018 - 2021 Efficient synthesis of mutifunctionalized cyclic compounds utilizing Lewis acid templates and its applications
2020 - 2021 自己会合型触媒を用いる複雑な多環性天然物の迅速合成
2018 - 2020 ルイス酸テンプレートを基軸とする多官能基化環状化合物の効率的合成とその応用展開
2016 - 2019 Total Synthesis of Nitrogen-containing Macrocyclic Natural Products Useful for Drug Discovery

2015 - 2018 Synthetic studies on portimine, a potent and selective inducer of apoptosis

2015 - 2017 アポトーシス誘導天然物ポルチミンの全合成研究

2013 - 2016 Efficient Synthesis of Natural Products Useful for Drug Discovery Based on Innovative Synthetic Methodologies

2012 - 2015 Synthesis of Biologically Active Bislactone Utilizing an Indium-mediated Reformatsky-Claisen Rearrangement and Development of Chiral Claisen Rearrangement

2012 - 2014 転位反応を駆使した生物活性ビスラクトンの合成および不斉クライゼン転位反応の開発

2010 - 2012 Efficient Synthesis of Biologically Active Natural Products Useful for Drug Discovery

2009 - 2011 Synthetic Studies on Spirolide, a Macrocyclic Alkaloid, having potential neurotoxicity

2009 - 2011 特異な神経毒性を有する大環状アルカロイド、スピロライドの合成

2007 - 2009 Efficient Synthesis of Natural Products Having Intriguing Biological Activities Useful for Drug Discovery

2004 - 2007 α-ケトエステルを基質とする効率的置換クエン酸不斉構築法の開発

2005 - 2006 Synthetic Studies of Natural Products Using By a Chelation Controlled Claisen Rearrangement

2005 - 2006 新規キレーション制御クライゼン転位反応を基軸とする天然物合成

2004 - 2005 アポトーシス誘導活性環状ペプチド、クロプトシンの全合成研究

2002 - 2003 海洋生物由来の多元素環状化合物の不斉全合成

2001 - 2002 Synthetic Studies on Insect Repellent Agent, Azadirachtin, and its Mechanistic Studies

2001 - 2002 昆虫忌避物質アザジラクチンの合成および作用機序に関する研究

2001 - 2001 含窒素スピロ環状海産毒の全合成研究

2001 - 含窒素スピロ環状海産毒の全合成研究

1999 - 2000 環状イミノ骨格を有する微量貝毒の全合成研究

1993 - 1999 環状ブロモエーテル化合物の生合成研究

1997 - 1998 昆虫摂食阻害物質アザジラクチンの不斉全合成

1996 - 1996 植物の防御に関わる化学物質の合成研究

1996 - ??A???̖h???Ɋւ??鉻?w?????̍???????

1995 - 海産由来環状ブロモエーテル化合物の生合成研究

1993 - 生理活性天然物の合成

1993 - 海産天然毒の合成研究

1993 - Synthetic Studies of biologically active compounds, derived from plants

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Papers (135)：

Jun Ishihara. Progress in Lewis-Acid-Templated Diels-Alder Reactions. Molecules. 2024
Jun Takouda, Moeka Nakamura, Akane Murasaki, Waka Shimosako, Aoi Hidaka, Shino Honda, Susumu Tanimura, Fumito Ishibashi, Norihiko Kawasaki, Jun Ishihara, et al. Identification of Azalamellarin N as a Pyroptosis Inhibitor. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 28-36
Keita KOMINE, Yuta YAMAZAKI, Taiga IWANAGA, Hikaru SAKAGUCHI, Hayato FUKUDA, Jun Ishihara. Visible-Light-Induced Three-Component Radical Coupling of Selenocarbamates, Enones, and Allylstannanes with Diphenyl(2,4,6-trimethylbenzoyl)phosphine Oxide. Synlett. 2023
Satoshi Mizuta, Masahiro Tabira, Naoki Shichiro, Tomoko Yamaguchi, Jun Ishihara, Takeshi Ishikawa. Reaction Mechanism and Origin of Stereoselectivity in the Fluorination and Trifluoromethylthiolation of 2-Bromoamides with AgF and AgSCF3. European Journal of Organic Chemistry. 2023
Jun Ishihara, Norihiko Kawasaki, Yu Kikuoka, Keita Komine, Hayato Fukuda. Concise Formal Synthesis on Solandelactone E Based on a Regioselective Cyclopropanation. HETEROCYCLES. 2023. 106. 2. 346-346

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MISC (53)：

坂田淳, 佐藤晋平, 小嶺敬太, 福田隼, 渡邉瑞貴, 周東智, 石原淳. Synthetic Study of Ansamycin Natural Product Cytotrienin A. 複素環化学討論会講演要旨集. 2021. 50th
Jun Ishihara. Chiral Lewis Acid-template Diels-Alder Reaction and the Application of Natural Product Synthesis. Journal of Synthetic Organic Chemistry, Japan. 2020. 78. 3. 204-212
堤智寛, 松本萌, 岩崎瞳, 富澤慧, JACQUES Eustache, 小嶺敬太, 福田隼, 畑山範, 石原淳. Synthetic Studies of Thuggacin cmc-A. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
川崎則彦, 小嶺敬太, 福田隼, 石原淳. Synthetic Studies on Bisgersolanolide. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
小嶺敬太, 浦山泰洋, 保坂拓, 山下裕貴, 福田隼, 畑山範, 石原淳. Formal Synthesis of (-)-Haliclonin A. 複素環化学討論会講演要旨集. 2020. 49th

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Patents (1)：

新規キノリン誘導体およびこれを含有する有機触媒

Books (3)：

Marine natural products / Topics in Heterocyclic Chemistry 58
Springer 2021 ISBN:9789811646362
Total Syntheses of (+)-Eremantholide A and (-)-Verrucarol : Form D-Glucose to Biologically Intriguing Sesquiterpenes
Studies in Natural Products Chemistry 2000
Total Syntheses of (+)-Eremantholide A and (-)-Verrucarol : Form D-Glucose to Biologically Intriguing Sesquiterpenes
Studies in Natural Products Chemistry 2000

Lectures and oral presentations (41)：

タンデム反応に基づく多環性天然物の合成展開
(九州大学大学院理学附特別講演会 2023)
タンデム反応に基づく多環性天然物の合成展開
(九州大学先導物質化学研究所特別講演会 2023)
Recent Advances in the Total Synthesis of Macrocyclic Natural Products
(7th Gratama Workshop 2023)
ペリ環状反応を基軸とする天然物合成の展開
(API 講演会 2023)
Lewis Acid Template-Catalyzed Asymmetric Diels-Alder Reaction and Application to the Natural Products Synthesis
(The 15th International Symposium on Organic Reactions (ISOR-15) 2022)

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Works (7)：

特異な神経毒性を有する大環状アルカロイド、スピロライドの合成
2009 - 2012
A New Variant of Reformatsky-Claisen Rearrangement Mediated by Indium Chloride
2011 -
特異な細胞機能制御活性を有する創薬リード天然物の高効率合成
2008 - 2010
αーケトエステルを基質とする効率的置換クエン酸不斉構築法の開発
2006 - 2008
新規キレーション制御クライゼン転位反応を基軸とする天然物合成
2005 - 2007

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Education (6)：

- 1993 Keio University
- 1993 Keio University Graduate School, Division of Engineering
- 1990 Keio University
- 1990 Keio University Graduate School, Division of Engineering
- 1984 Keio University Faculty of Science and Technology Department of Applied Chemistry

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Professional career (1)：

PhD (Keio University)

Work history (12)：

2017/04/01 - Professor,Pharmaceutical Sciences,Pharmaceutical Sciences,Graduate School of Biomedical Sciences,Nagasaki University
2008 - 2017/03/31 Associate Professor,Pharmaceutical Sciences,Pharmaceutical Sciences,Graduate School of Biomedical Sciences,Nagasaki University
2008 - 2017 Nagasaki University Graduate School of Biomedical Sciences
2010 - Chair, Universite de Haut-Alsace, ENSCMu
2003 - 2008 Nagasaki University Graduate School of Biomedical Sciences

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Committee career (14)：

2018 - 現在複素環化学討論会世話人
2018 - 現在天然有機化合物討論会世話人
2023/04 - 日本化学会代表正会員
2014 - 2018 有機合成化学協会九州山口支部幹事
2015 - 2016 日本薬学会代議員

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Awards (3)：

2020 - Nagase Science and Technology Foundation Nagase Science and Technology Award Synthesis of Functionalized Cyclic Natural Products by Self-Assembling Catalysts
2005 - The Society of Synthetic Organic Chemistry, Japan Research Planning Award Synthetic Studies of Natural Products Using By a Chelation Controlled Claisen Rearrangement
1999 - The Chemical Society of Japan Presentation Awards for young chemists Progress towards the Total Synthesis of Azadirachtin

Association Membership(s) (6)：

International Society of Heterocyclic Chemistry , 日本コンピューター化学会 , 有機合成化学協会 , 日本薬学会 , American Chemical Society , 日本化学会

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