Hiroaki Hidekazu

ヒロアキヒデカズ | Hiroaki Hidekazu

Affiliation and department：
Job title：教授
Homepage URL (1)： http://presat-vector.org/hiroaki-lab/

Research field (3)： Pharmaceuticals - analytical and physicochemistry , Pharmaceuticals - chemistry and drug development , Biophysics

Research theme for competitive and other funds (19)：

2024 - 2027 PDZ足場タンパク質の機能に介入する阻害剤ライブラリの構築と創薬応用
2017 - 2020 Propagation of Alzheimer's disease neuronal cell death by intracellular formation and secretion of abnormal aggregates
2015 - 2018 Development of NMR drug discovery pipeline using database
2014 - 2017 Elucidation of a neurodegenerative mechanism induced by a new Alzheimer's disease drug target and its inhibition
2016 - 2017 Application of molecular shielding effect of intrinsically disordered proteins towards development of protein stabilizers

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Papers (104)：

Koya Miura, Youichi Suzuki, Kotaro Ishida, Masashi Arakawa, Hong Wu, Yoshihiko Fujioka, Akino Emi, Koki Maeda, Ryusei Hamajima, Takashi Nakano, et al. Distinct motifs in the E protein are required for SARS-CoV-2 virus particle formation and lysosomal deacidification in host cells. Journal of virology. 2023. 97. 10. e0042623
Yuri Emoto, Ryoya Katayama, Emi Hibino, Sho Ishihara, Natsuko Goda, Takeshi Tenno, Yoshihiro Kobashigawa, Hiroshi Morioka, Hidekazu Hiroaki. A Cost-Effective Immobilization Method for MBP Fusion Proteins on Microtiter Plates Using a Gelatinized Starch-Agarose Mixture and Its Application for Convenient Protein-Protein Interaction Analysis. Methods and Protocols. 2023. 6. 3. 44-44
Mio Nakashima, Natsuko Goda, Takeshi Tenno, Ayaka Kotake, Yuko Inotsume, Minako Amaya, Hidekazu Hiroaki. Pharmacologic Comparison of High-Dose Hesperetin and Quercetin on MDCK II Cell Viability, Tight Junction Integrity, and Cell Shape. Antioxidants (Basel, Switzerland). 2023. 12. 4
Takamasa Mizoguchi, Shohei Mikami, Mari Yatou, Yui Kondo, Shuhei Omaru, Shuhei Kuwabara, Wataru Okura, Syouta Noda, Takeshi Tenno, Hidekazu Hiroaki, et al. Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage. International journal of molecular sciences. 2023. 24. 5
Hidekazu Hiroaki. Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges. Biophysics and physicobiology. 2023. 20. 1. e200007

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MISC (65)：

Hidekazu Hiroaki. Drug Discovery by Targeting Intrinsically Disordered Proteins - Potential and Challenges. MedChem News. 2022. 32. 3. 136-139
Hidekazu Hiroaki. Perspective for epitherial barrier enhancement by modulating homeostasis of tight junction. FRAGRANCE JOURNAL. 2022. 50. 5. 34-41
Hidekazu HIROAKI. Insights into the Mechanisms of Oligomerization/Fibrilization of Amyloid β Peptide from Nuclear Magnetic Resonance. Seibutsu Butsuri. 2022. 62. 1. 39-42
廣明秀一. 【構造生命科学による創薬への挑戦】計算機から創薬へ天然変性タンパク質と創薬. 医学のあゆみ. 2021. 278. 6. 653-662
廣明秀一, 天野剛志. Rational Drug Discovery for Inhibiting Ubiquitination of Magnesium Channels. ソルト・サイエンス研究財団助成研究報告集 2 医学食品科学編. 2021. 2019

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Patents (19)：

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Books (3)：

Lectures and oral presentations (151)：

Development of drugs targeting the interaction between the SARS-CoV-2 envelope and host PDZ-containing proteins
(日本ウイルス学会学術集会プログラム・予稿集(Web) 2021)
Usefulness and cautionary points of post-synthetic modification of oligonucleotides by click
(日本核酸医薬学会年会講演要旨集(CD-ROM) 2021)
Analysis of Pharmacological Effects of Dvl Inhibitors on Triple Negative Breast Cancer Cells
(日本分子生物学会年会プログラム・要旨集(Web) 2021)
A construction of useful binding assay for interactions PDZ domain and carboxy-terminal tail by using microtiter plates
(日本分子生物学会年会プログラム・要旨集(Web) 2021)
The role of E protein on the formation of SARS-CoV-2 Virus-Like Particle
(日本分子生物学会年会プログラム・要旨集(Web) 2021)

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Education (3)：

1989 - 1992 Osaka University Graduate School, Division of Pharmaceutical Sciences
1987 - 1989 Osaka University Graduate School, Division of Pharmaceutical Sciences
1984 - 1987 Osaka University Faculty of Pharmaceutical Science

Professional career (3)：

Work history (11)：

2021/04 - 現在 Nagoya University Graduare School of Pharmaceutical Sciences Dean
2012/04 - 現在 Nagoya University Graduare School of Pharmaceutical Sciences Proffesor
2013/04 - 2023/03 Nagoya University Cellular and Structural Physiology Institute Director in General
2015/04 - 2021/03 Nagoya University AIP Depuity of Director in General
2015/04 - 2019/03 Nagoya University Division of Human Resource Development Business Capacity Development Center Director in General

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Association Membership(s) (7)：

American Association for the Advancement of Science , 日本分子生物学会 , 日本ケミカルバイオロジー学会 , 日本生物物理学会 , 日本蛋白質科学会 , 日本核磁気共鳴学会 , 日本薬学会

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