Takahashi Akiko

Takahashi Akiko | Takahashi Akiko

Affiliation and department：
Job title： Chief

Research field (3)： Tumor biology , Oral medicine (pathology) , Molecular biology

Research keywords (5)： Epigenetics , SASP , Exosome , 分子生物学 , Molecular Biology

Research theme for competitive and other funds (9)：

2022 - 2025 染色体構造異常によるがんの悪性化機構の解析
2021 - 2023 自己DNAを標的としたSASP制御への挑戦
2019 - 2022 Functional Analysis of Cytoplasmic Nucleic Acid Sensor in the Tumor Microenvironment
2019 - 2021 Challenge for elucidation of cross talk between cellular senescence and cell competition
2017 - 2019 老化細胞分泌因子による細胞競合制御機構の解明

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Papers (52)：

Masatomo Chiba, Kenichi Miyata, Hikaru Okawa, Yoko Tanaka, Koji Ueda, Hiroyuki Seimiya, Akiko Takahashi. YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype. International Journal of Molecular Sciences. 2023. 24. 22. 16399-16399
Kenichi Miyata, Xiangyu Zhou, Mika Nishio, Aki Hanyu, Masatomo Chiba, Hiroko Kawasaki, Tomo Osako, Kengo Takeuchi, Shinji Ohno, Takayuki Ueno, et al. Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 32. e2305046120
Tomoka Misawa, Kazuhiro Hitomi, Kenichi Miyata, Yoko Tanaka, Risa Fujii, Masatomo Chiba, Tze Mun Loo, Aki Hanyu, Hiroko Kawasaki, Hisaya Kato, et al. Identification of Novel Senescent Markers in Small Extracellular Vesicles. International Journal of Molecular Sciences. 2023. 24. 3. 2421-2421
Kenichi Miyata, Akiko Takahashi. Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression. Nucleus. 2022
Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, et al. RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. Communications Biology. 2022. 5. 1

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MISC (61)：

千葉正智, 三澤知香, 田中陽子, 高橋暁子. 【EVs 細胞外小胞の生物学エクソソームをはじめとする多様な小胞の生理・病理の理解と新しい解析法】(第1章)細胞外小胞の形成と伝播のメカニズム細胞老化と細胞外小胞. 実験医学. 2021. 39. 20. 3148-3153
高橋暁子, 原英二. いま知りたい!!cGAS-STING経路がいま熱い!明かされる多彩な生命現象への関与と高まる治療標的としての期待 cGAS-STING経路は細胞老化による炎症反応を誘発する. 実験医学. 2021. 39. 9. 1391-1394
荒谷紗絵, 田中陽子, 酒井直行, 高橋暁子. 老化細胞が分泌する細胞外小胞と腎臓における細胞外小胞の機能. 2020. 12. 233-239
菅原祥, 宮田憲一, 田中久道, 高橋暁子. 老化研究と細胞老化の基礎. バイオマテリアル学会誌. 2020. 38. 160-165
高橋暁子, 宮田憲一, 羅智文, 菅原祥. The Analysis of Epigenetic alteration in cellular senescence and cancer. 日本癌学会学術総会抄録集(Web). 2020. 79th

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Books (4)：

がん分子標的治療研究実践マニュアル
金芳堂 2009
Degradayion factors of Dental Polycarbonate
2001
Degradation Factors of Dental Polycarbonates
"Caries Preventive Restoration" Forum in Sapporo '99 2001
Long-term Durability of Resin-dentin Bonds
Modern Trands in Adhesive Dentistry Proceedings of the Adhesive Dentistry Forum'99 in tsurumi 1999

Education (3)：

Professional career (2)：

Work history (2)：

2022/10 - 現在 Japanese Foundation for Cancer Research Division of Cellular Senescence, Cancer Institute Chief
2017/04 - 2022/09 Japanese Foundation for Cancer Research Project for Cellular Senescence, Cancer Institute Project Leader

Awards (4)：

Association Membership(s) (7)：

日本生化学会 , International Society for Extracellular Vesicles , International Cellular Senescence Association , 歯科保存学会 , 日本病理学会 , 日本分子生物学会 , 日本癌学会

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