Research field (3)：
Molecular biology
, Medical biochemistry
, Cell biology
Research keywords (5)：
epigenetics
, breast cancer
, chromatin
, non-coding RMA
, cell nucleus
Research theme for competitive and other funds (15)：
2020 - 2024 エレノアの液滴形成による転写活性化と乳がん再発における役割解明
2018 - 2023 核内RNAボディによるクロマチン制御機構の解明
2018 - 2021 Investigation of a mechanism for chromatin domain transition in differentiation and tumorigenesis
2016 - 2019 The active chromatin domain that is regulated by the non-coding RNAs in recurrent breast cancer
2015 - 2018 International research network for chromatin structure, dynamics, and function
2013 - 2018 Regulation of chromatin structure and dynamics by interplay between nuclear sub-structures and chromatin
2013 - 2018 Chromatin structure, dynamics, and function
2012 - 2017 Elucidation of mechanisms of transcription cycle using multi-color, single-molecule, quantitative fluorescence imaging of living cell nuclei.
2013 - 2016 Mechanism of nucleolar formation and its nutritional stress response
2013 - 2014 核スペックルとESR1遺伝子座の協調による転写調節
2011 - 2013 画像解析を用いた染色体間ドメイン構築ネットワークの解析
2009 - 2010 染色体間ドメインの制御と核形態の定量的解析
2007 - 2008 細胞の増殖・分化における核内構造体の形成機構と機能の解析
2006 - 2007 Functional analysis of SUMO modification in nuclear architecture and transcription regulation
2005 - 2006 細胞の増殖分化に関わる遺伝子発現と核内構造の時空間的解析
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Papers (52)：
Kenji Watanabe, Tatsuro Yamamoto, Tomoko Fujita, Shinjiro Hino, Yuko Hino, Kanami Yamazaki, Yoshimi Ohashi, Shun Sakuraba, Hidetoshi Kono, Mitsuyoshi Nakao, et al. Metabolically inducing defects in DNA repair sensitizes BRCA -wild-type cancer cells to replication stress. Science Signaling. 2024. 17. 862
Hidefumi Suzuki, Ryota Abe, Miho Shimada, Tomonori Hirose, Hiroko Hirose, Keisuke Noguchi, Yoko Ike, Nanami Yasui, Kazuki Furugori, Yuki Yamaguchi, et al. The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies. Nature Communications. 2022. 13. 1. 2905
Megumi Fukuoka, Yuichi Ichikawa, Tomo Osako, Tomoko Fujita, Satoko Baba, Kengo Takeuchi, Nobuyuki Tsunoda, Tomoki Ebata, Takayuki Ueno, Shinji Ohno, et al. The ELEANOR non-coding RNA expression contributes to cancer dormancy and predicts late recurrence of ER-positive breast cancer. Cancer Science. 2022. 113. 7. 2336-2351
Haruka Matsumori, Kenji Watanabe, Hiroaki Tachiwana, Tomoko Fujita, Yuma Ito, Makio Tokunaga, Kumiko Sakata-Sogawa, Hiroko Osakada, Tokuko Haraguchi, Akinori Awazu, et al. Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly. Life science alliance. 2022. 5. 7. e202101045
Kazumitsu Maehara, Kosuke Tomimatsu, Akihito Harada, Kaori Tanaka, Shoko Sato, Megumi Fukuoka, Seiji Okada, Tetsuya Handa, Hitoshi Kurumizaka, Noriko Saitoh, et al. Modeling population size independent tissue epigenomes by ChIL-seq with single thin sections. Molecular Systems Biology. 2021. 17. 11. e10323
Non-coding RNAs regulate the 3D genome architecture in breast cancer.
(6th International Anatomical Sciences and Cell Biology Conference 2022)
ELEANOR non-coding RNAs associate with chromatin and regulate the 3D genome structure in breast cancer.
(The 30th Hot Spring Harbor International Symposium Chromatin Potential in Development and Differentiation, The 6th Symposium of the Inter-University Research Network for Trans-Omics Medicine 2022)
