Rchr
J-GLOBAL ID：200901079918898178
Update date: Oct. 31, 2024
Iwabuchi Kazuhisa
イワブチ カズヒサ | Iwabuchi Kazuhisa
Affiliation and department：
Job title：
Specially Appointed Professor
Other affiliations (2)：
Homepage URL (2)：
http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/index.html
,
http://www.juntendo.ac.jp/graduate/nurs/research/profile_12.html
Research field (4)：
Immunology
, Medical biochemistry
, Cell biology
, Structural biochemistry
Research keywords (7)：
糖鎖生物学
, 細胞生物学
, 免疫学
, 生化学
, Cell Biology
, Immunology
, Biochemistry
Research theme for competitive and other funds (25)：
- 2023 - 2026 Crosstalk between purinergic signaling and the complement system in sepsis-induced immunosuppression.
- 2019 - 2022 Excessive complement activation in multiple organ dysfunciton
- 2016 - 2020 Mechanisms of liver regeneration mediated by sinusoidal microcirculation in the regulation of autotaxin and lysophospholipid
- 2015 - 2018 Palmitic acid elicits insulin resistance and oxidative cell injury through clusterization of lipid rafts in murine hepatocytes.
- 2015 - 2017 Development of glycosylated lipid metabolomics system for clarifying their neuronal function
- 2013 - 2017 Mechanism of liver regeneration in regulation of sinusoidal remodeling through vascular nich
- 2012 - 2015 Integrative genomic and proteomic analyses of low-dose ionizing radiation in EBV infected-B cells
- 2012 - 2014 Challenging study to clarify mechanisms of multiple organ failure
- 2012 - 2014 Effetct of Pseudomonas aeruginosa-derived neutral ceramidase on immunological responses of three-dimensionally cultured human primary keratinocytes
- 2011 - 2013 The development of anti-atherogenic exercise program by regulating skeletal muscle inflammation
- 2009 - 2011 Tyrosine kinase inhibitor induce CML migration to stromal microenvironment through Lyn/CXCR4 interactions in lipid rafts
- 2009 - 2011 Novel trial to control acute lung injury by regulating neutrophil function targeting for A3 adenosine receptor
- 2005 - 2009 The role of the extracellular matrix in focal localization of signal molecules
- 2004 - 2005 Quantitative proteomic and lipidomic analysis of detergent-resistant membrane microdomain involved in signal transduction
- 2004 - 2005 病原性抗酸菌の好中球食胞形成機構におけるリピッドラフトの役割の解明
- 2003 - 2003 好中球の貧食におけるリピッドラフトの役割の解明
- 2002 - 2002 好中球の貪食におけるリピッドラフトの役割の解明
- 2000 - 2002 Study about structure and function of neutrophil-glycosignaling domain
- 感染経路解析と院内感染対策法の開発
- 自然免疫応答に及ぼす内分泌攪乱物質・環境因子の影響解析
- 細胞内寄生細菌の貪食回避機構の解明
- 貪食細胞、特に好中球の接着・遊走および貪食に関与するスフィンゴ糖脂質マイクロドメイン(リピドラフト)の構造と、それを介した情報伝達機構に関する研究
- Evaluation of the effect of exogenous endocrine disrupting chemicals on innate immune system
- Molecular dynamics of escape mechanisms of mycobacterium from neutrophil killing
- Elucidation of structure and signal transduction mechanisms of glycosphingolipid-enriched membrane microdomains involved in adhesion, migration and phagocytosis of leukocytes
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Papers (130)：
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Irene van der Haar Àvila, Tao Zhang, Victor Lorrain, Florance de Bruin, Tianne Spreij, Hitoshi Nakayama, Kazuhisa Iwabuchi, Juan J García-Vallejo, Manfred Wuhrer, Yvette van Kooyk, et al. Limited impact of cancer-derived gangliosides on anti-tumor immunity in colorectal cancer. Glycobiology. 2024. 34. 7
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花房 慶, 中山 仁志, 小畑 謙太朗, 大嶋 恵理子, 山地 俊之, 平林 義雄, 岩渕 和久. マクロファージの抗酸菌殺菌機構における極長鎖脂肪酸鎖を持つスフィンゴ脂質とその合成酵素の役割について. 脂質生化学研究. 2024. 66. 223-224
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YAMANE YUI, LI XIAOJIA, HANAFUSA KEI, NAKAYAMA HITOSHI, WATANABE KOJI, IWABUCHI KAZUHISA, HAYASHIDA MASAKAZU. Dexmedetomidine Pretreatment of Neuronal Cells Has Protective Effect Against Cell Death During Oxygen-glucose Deprivation/Reoxygenation, Based on IGF-1 Production. Juntendo Medical Journal. 2024. advpub
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島井 亮輔, 花房 慶, 中山 仁志, 宮崎 哲朗, 戸叶 隆司, 平林 義雄, 岩渕 和久, 南野 徹. リゾホスファチジルグルコシド/GPR55受容体シグナルはM2cヒトマクロファージにおける脂質代謝を制御する. 日本心臓病学会学術集会抄録. 2023. 71回. O-5
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Ryosuke Shimai, Kei Hanafusa, Hitoshi Nakayama, Eriko Oshima, Masaki Kato, Koki Kano, Ichiro Matsuo, Tetsuro Miyazaki, Takashi Tokano, Yoshio Hirabayashi, et al. Lysophosphatidylglucoside/GPR55 signaling promotes foam cell formation in human M2c macrophages. Scientific reports. 2023. 13. 1. 12740-12740
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MISC (408)：
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大野 瑛明, 山下 智大, 狩野 航輝, 岩渕 和久, 平林 義雄, 松尾 一郎, 上口 裕之, 中島 康晴, 津田 誠. GPR55は脊柱管狭窄に伴う好中球の浸潤と慢性疼痛の発症に寄与する. 日本整形外科学会雑誌. 2022. 96. 8. S1852-S1852
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村上和哉, 渡邊真衣, 花房慶, 中山仁志, 岩渕和久, 田中浩士. Synthesis and Functional Evalution of α(1,2) mannoside (Mannancap) to Bactericidal Evasion of Mycobacterium tuberculosis. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
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岩渕 和久. 感染症と免疫応答-糖脂質を介した自然免疫応答-. 化学と教育. 2021. 69. 11. 468-471
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王 迪, 工藤 綾子, 川上 和美, 岩渕 和久. 特別養護老人ホームに勤める看護師・介護職員のノロウイルス感染症対策を実施する際に遭遇した課題-Challenges Encountered with Norovirus Infection Control Among Nurses and Nursing Care Staff in Nursing Homes. 医療看護研究 = Journal of health care and nursing. 2021. 17. 2. 34-41
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花房慶, LI Xiaoja, 堀田知美, 大嶋恵理子, 中山仁志, 中山仁志, 狩野航輝, 松尾一郎, 伊藤拓夢, 上口裕之, et al. PhosphatidylGlueoside is involved in neutrophil homeostasis. 日本糖質学会年会要旨集. 2021. 40th
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Books (3)：
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臨床看護学用語辞典
医学芸術社 2002
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Assays of sphingosine-dependent kinase for 14-3-3 protein.(共著)
Sphingolipid metabolism and cell signaling, Part B In : Methods in Enzymology. 2000
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Separation of glycosphingolipid-enriched microdomains from caveolar membrane characterized by presence of caveolin.(共著)
Sphingolipid metabolism and cell signaling, Part B In : Methods in Enzymology. 2000
Works (2)：
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血小板由来好中球接着能阻害因子(AIF)に関する研究
1902 - 1996
-
Study on platelet-derived neutrophil-adherent inhibiting factor
1902 - 1996
Education (4)：
- - 1986 Osaka University
- - 1986 Osaka University Graduate School, Division of Pharmaceutical Sciences
- - 1984 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy
- - 1984 Tokyo University of Science Faculty of Pharmaceutical Science
Professional career (2)：
- Ph.D. (Juntendo University)
- Master degree (Osaka University)
Work history (17)：
- 2024/04 - 現在 Juntendo University Faculty of Pharmacy, Specially appointed Professor
- 2023/04 - 現在 Juntendo University Graduate School of Medicine Special appointed professor
- 2023/04 - 現在 Juntendo University GraduateSchool OFFHealthcare andNursing Special appointed professor
- 2010/04 - 現在 理化学研究所 脳科学研究センター 客員研究員
- 2023/04 - 2024/03 Juntendo University Preparation office for establishment of the Faculty of Pharmacy Specially Appointed Professor
- 2022/02 - 2023/03 Juntendo University Graduate School of Medicine Professor
- 2007/04 - 2023/03 Juntendo University
- 2007/04 - 2023/03 Juntendo University Faculty of Health Care and Nursing
- 2004/04 - 2022/01 Juntendo University Graduate School of Medicine
- 2010/05 - 2018/03 理化学研究所 基幹研究所 客員研究員
- 2004/04 - 2006/03 - 順天堂大学医療看護学部助教授
- 2002/04 - 2005/03 -理化学研究所 フロンティアシステム 客員研究員
- 2002 - 2004/03 Juntendo University Faculty of Medicine
- 1986 - 2002 Juntendo University Faculty of Medicine
- 1986 - 2002 Research associate, Department of Biochemistry, Juntendo University School of Medicine
- 2002 - - visiting scientist, Riken Frontier System
- 2002 - - Lecurer, Department of Biochemistry, Juntendo University School of Medicine
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Committee career (6)：
- 2012/10 - 現在 セラミド研究会 顧問
- 2010/07 - 現在 日本脂質生化学会 幹事
- 2008/09 - 現在 日本糖質学会 評議員
- 2006/10 - 現在 日本生化学会 評議員
- 2006/07 - 現在 日本炎症・再生医学会 評議員
- 2004/12 - FCCA 幹事
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Association Membership(s) (6)：
アメリカSciety for Leukocyte Biology
, FCCA
, アメリカ生化学・分子生物学会
, 日本糖質学会
, 日本炎症学会
, 日本生化学会
