J-GLOBAL ID:200901079918898178   Update date: Oct. 15, 2018


イワブチ カズヒサ | IWABUCHI Kazuhisa
Affiliation and department:
Job title: Professor
Homepage URL  (2): http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/index.htmlhttp://www.juntendo.ac.jp/graduate/nurs/research/profile_12.html
Research field  (4): Structural biochemistry ,  Cell biology ,  General medical chemistry ,  Immunology
Research keywords  (3): Biochemistry ,  Immunology ,  Cell Biology
Research theme for competitive and other funds  (3):
  • Elucidation of structure and signal transduction mechanisms of glycosphingolipid-enriched membrane microdomains involved in adhesion, migration and phagocytosis of leukocytes
  • Molecular dynamics of escape mechanisms of mycobacterium from neutrophil killing
  • Evaluation of the effect of exogenous endocrine disrupting chemicals on innate immune system
Papers (47):
  • Iwabuchi K. Gangliosides in the Immune System: Role of Glycosphingolipids and Glycosphingolipid-Enriched Lipid Rafts in Immunological Functions. Methods in molecular biology (Clifton, N.J.). 2018. 1804. 83-95
  • Iwabuchi K. [Lactosylceramide-enriched Lipid Raft-mediated Infection Immunity]. Medical mycology journal. 2018. 59. 3. J51-J61
  • Kakayama H, Iwabuchi K. [Organization and function of glycosphingolipid-enriched lipid raft: Lactosylceramide-enriched lipid raft-mediated innate immune responses]. Seikagaku. The Journal of Japanese Biochemical Society. 2017. 89. 1. 62-72
  • Sueyoshi K, Sumi Y, Inoue Y, Kuroda Y, Ishii K, Nakayama H, Iwabuchi K, Kurishita Y, Shigemitsu H, Hamachi I, Tanaka H. Fluorescence imaging of ATP in neutrophils from patients with sepsis using organelle-localizable fluorescent chemosensors. Annals of intensive care. 2016. 6. 1. 64
  • Nakayama H, Kurihara H, Morita YS, Kinoshita T, Mauri L, Prinetti A, Sonnino S, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K. Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils. Science signaling. 2016. 9. 449. ra101
MISC (350):
Books (2):
  • Separation of glycosphingolipid-enriched microdomains from caveolar membrane characterized by presence of caveolin.(共著)
    Sphingolipid metabolism and cell signaling, Part B In : Methods in Enzymology. 2000
  • Assays of sphingosine-dependent kinase for 14-3-3 protein.(共著)
    Sphingolipid metabolism and cell signaling, Part B In : Methods in Enzymology. 2000
Works (1):
  • Study on platelet-derived neutrophil-adherent inhibiting factor
    1902 - 1996
Education (2):
  • - 1984 Tokyo University of Science Faculty of Pharmaceutical Science
  • - 1986 Osaka University Graduate School, Division of Pharmaceutical Sciences
Professional career (2):
  • Ph.D. (Juntendo University)
  • Master degree (Osaka University)
Work history (3):
  • 1986 - 2002 Research associate, Department of Biochemistry, Juntendo University School of Medicine
  • 2002 - Lecurer, Department of Biochemistry, Juntendo University School of Medicine
  • 2002 - visiting scientist, Riken Frontier System
Association Membership(s) (3):
Japanese Biochemical Sciety ,  Japanese Inflammatory Sciety ,  Japanese Glycobiology Scitetly
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