Kakita Akiyoshi

2021 - 2025 Chemo-sensitization of brain tumors by manipulation of SLFN11

2021 - 2024 Visualization of microenvironments of malignant glioma utilizing 7T-MRI and 3D tissue clearing technology

2020 - 2023 自己免疫性グリア病における時空間的免疫制御によるneural repairの研究

2020 - 2022 Digital 3D Neuropathology: Methodological Platform Creation

2019 - 2022 Microglia-astrocyte crosstalk in leukoencephalopathies

2019 - 2022 Comprehensive epileptic network analysis in human brain by neuron and glia

2019 - 2022 Ex vivo optical imaging of human brain tissues for visualization of epileptogenic networks.

2019 - 2022 Mechanism of inactivation of neuropathogenic protein toxicity by aggresomes

2019 - 2022 Pathomechanisms and Control of Epileptogenic Foci: Imaging Practices for Surgical Specimens

2019 - 2022 Mechanisms of lesion formation in Parkinson's disease: an analysis using tissue clearing and 3D observation

2017 - 2022 Visualization of epileptogenic foci of MRI non-lesional neocortical epilepsy patients by 7T-MRI

2016 - 2019 Microglial involvement in the pathomechanisms of white matter degeneration

2016 - 2019 Stages of glial inclusion pathology in multiple system pathology

2015 - 2019 On the transneuronal propagation in neurodegenerative diseases

2016 - 2018 A feasibility study for 3D neuropathology

2015 - 2018 Development of a preoperative highly accurate evaluation method to detect epileptic foci -Analyzing high frequency oscillations with dense array EEG-

2015 - 2018 Epileptogenesis in Mesial Temporal Lobe Epilepsy

2014 - 2017 Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning

2013 - 2017 Pathomechanisms underlying human temporal lobe epilepsy

2012 - 2017 Cytokine-Induced Neuropathologic Endophenotypes of Psychiatric Diseases

2013 - 2016 Regulation of neuronal cell size control in normal and disease condition

2013 - 2016 Autoreguation of TDP-43 in ALS

2013 - 2015 Pathogenesis of focal cortical dysplasia: possible mechanistic implification of somatic mutations

2010 - 2015 Personal genome analysis on Alzheimer's disease

2011 - 2014 A study on the molecular mechanisms of neurodegeneration induced by high-mass amyloid-beta assembly, amylospheroids (ASPD)

2011 - 2014 ALS and TDP-43: Dose the splicing failure underlie the pathogenesis of ALS?

2009 - 2014 Magnetic Resonance Molecular Microimaging

2010 - 2012 Molecular pathogenesis of ALS: approach from TDP-43 function.

2010 - 2011 Clarification of epileptogenicity using human brain slices in vitro

2009 - 2011 Spatiotemopral dynamics of epiletiform propagations in surgical specimens taken from patients with intractable epilepsy

2008 - 2010 Amyotrophic lateral sclerosis and TDP-43 : elucidation of the entire neuropathological picture and molecular pathomechanism

2005 - 2009 Comparative Transcriptome Study of Brain

2007 - 2008 Epileptogenic mechanisms underlying cortical lesions in patients with intractable seizures

2004 - 2006 Tracing of regenerating nerve along its length using adenovirus vector

2004 - 2005 内在性相補鎖RNAによる遺伝子発現調節機構に注目したシヌクレイン関連蛋白の解析

2004 - 2005 Molecular mechanisms underlying progenitor migration following methylmercury exposure in the developing brain

2001 - 2005 脳内サイトカインによる中枢神経機能の制御メカニズム:分子から精神活動へ

2003 - 2004 難治てんかん原性病巣としての「皮質形成異常」の分子病理学的診断基準の確立

2002 - 2003 Migration pathways and fate determination of progenitors in the subventricular zone

2000 - 2002 A study on the molecular pathomechanisms underflying intractable epilepsy

2000 - 2001 Investigation on migration mechanisms of glial progenitors: observations of living cells labeled by dual fluorescent molecules

1996 - 1996 ニューロブラストの産生および移動の障害に基づく脳奇形の形成機序に関する研究