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J-GLOBAL ID：200901080152924358   Update date: Mar. 20, 2024

Ikuta Koichi

イクタ コウイチ | Ikuta Koichi
Affiliation and department：
Kyoto University Institute for Frontier Life and Medical Sciences

About Kyoto University Institute for Frontier Life and Medical Sciences


Job title： Professor
Homepage URL  (1)： https://www2.infront.kyoto-u.ac.jp/Ikuta-Lab/
Research field  (3)： Immunology ,  Pathobiochemistry ,  Medical biochemistry
Research keywords  (10)： innate lymphoid cell ,  innate-like lymphocyte ,  glucocorticoid ,  sex hormone ,  circadian rhythm ,  lymphocyte ,  microenvironment ,  IL-7 receptor ,  cytokine receptor ,  cytokine
Research theme for competitive and other funds  (42)：
  • 2020 - 2023 IL-15-producing microenvironment supporting innate lymphoid cells and its role in diseases
  • 2020 - 2022 Induction of autoimmune diseases by glucocorticoids
  • 2017 - 2019 Regulation of immune microenvironment by IL-15-expressing cells in vivo
  • 2016 - 2019 Control of innate immune cells, chronic inflammation and infection by cytokine-producing immune microenvironment
  • 2016 - 2018 Control of dynamics and function of T cells by glucocorticoids via IL-7 receptor expression
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Papers (167)：
  • Koichi Ikuta, Takuma Asahi, Guangwei Cui, Shinya Abe, Daichi Takami. Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment. Advances in experimental medicine and biology. 2024. 1444. 111-127
  • Guangwei Cui, Shinya Abe, Ryoma Kato, Koichi Ikuta. Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues. Frontiers in immunology. 2024. 15. 1349184-1349184
  • Shinya Abe, Takuma Asahi, Takahiro Hara, Guangwei Cui, Akihiro Shimba, Shizue Tani-Ichi, Kohei Yamada, Kazuko Miyazaki, Hitoshi Miyachi, Satsuki Kitano, et al. Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell reports. 2023. 113127-113127
  • Guangwei Cui, Akihiro Shimba, Jianshi Jin, Nozomi Hojo, Takuma Asahi, Shinya Abe, Aki Ejima, Shinri Okada, Keizo Ohira, Ryoma Kato, et al. CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 36. e2215941120
  • Daichi Takami, Shinya Abe, Akihiro Shimba, Takuma Asahi, Guangwei Cui, Shizue Tani-Ichi, Takahiro Hara, Keishi Miyata, Masashi Ikutani, Kiyoshi Takatsu, et al. Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation. International immunology. 2023
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MISC (70)：
  • CUI Guangwei, 生田宏一. Circulating iNKT cells mediate antiviral and antitumor immunity. 医学のあゆみ. 2023. 286. 3
  • 榛葉 旭恒, 生田 宏一. 【免疫系の概日リズム】グルココルチコイドによる免疫応答能の概日制御. 医学のあゆみ. 2022. 281. 2. 159-163
  • 谷一 靖江, 生田 宏一. 【γδT細胞による生体制御】γδT細胞の恒常性維持機構. 炎症と免疫. 2022. 30. 3. 212-214
  • 谷一靖江, 生田宏一. 〈Basic Science〉γδT細胞による生体制御 γδT細胞の恒常性維持機構. 炎症と免疫. 2022. 30. 3
  • 山本れいこ, JIN Jianshi, CUI Guangwei, 竹内直志, 宮内栄治, 北條望, 大野博司, 大野博司, 生田宏一, 城口克之. Influence of vitamin A deficiency on the mouse gut microbiota revealed by our newly developed method,“BarBIQ”. 腸内細菌学雑誌. 2022. 36. 2
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Books (2)：
  • Role of the IL-7 receptor in γδ T-cell development from hematopoietic stem cells
    In “Hematopoietic Stem Cell Biology”. Kondo, M., ed. Humana Press Inc. pp143-159 2009
  • Developmental potential of fetal hematopoietic stem cells.
    In " Hematopoietic stem cells: Biology and therapeutic applications". Levitt, D. J., and Mertelsmann, R. eds. pp69-83. 1995
Lectures and oral presentations  (124)：
  • ストレスはグルココルチコイドを介してTh17細胞の分化を促進し腸炎を増悪させる
    (Kyoto T Cell Conference 第30回学術集会 2021)
  • ステロイドホルモンによる免疫機能とアレルギーの制御
    (日本アレルギー学会学術集会、JSA-JSI Joint Session 2021)
  • 胎児肝臓に由来する1型自然リンパ球の同定
    (Kyoto T Cell Conference 第30回学術集会 2021)
  • Circadian control of immunity by glucocorticoid
    (2020)
  • 免疫学の視点からコロナ時代を見る
    (東京大学医学部 医学序論連続講座シリーズXX「医の原点」 2020)
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Education (4)：
  • 1984 - 1987 Kyoto University Graduate School of Medicine
  • 1983 - 1984 Osaka University Graduate School of Medicine
  • 1979 - 1983 The University of Tokyo Faculty of Medicine School of Medicine
  • 1977 - 1979 The University of Tokyo College of Arts and Sciences
Professional career (1)：
  • Doctor of Medicine (Kyoto University)
Work history (9)：
  • 2022/04 - 現在 Kyoto University Institute for Life and Medical Institute Professor
  • 2016/10 - 2022/03 Kyoto University Institute for Frontier Life and Medical Sciences Professor
  • 2002/04 - 2016/09 Kyoto University Institute for Virus Research Professor
  • 1996/07 - 2002/03 Kyoto University Graduate School of Medicine Associate Professor
  • 1992/03 - 1997/03 The University of Tokyo Faculty of Medicine Visiting Associate Professor
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Committee career (4)：
  • 2003 - 現在 日本生化学会 評議員
  • 1997 - 現在 日本免疫学会 評議員
  • 2005 - 2010 日本免疫学会 学会のあり方検討委員会委員
  • 2000 - 2005 日本免疫学会 教育推進委員会委員
Awards (1)：
  • 2002 - 日本免疫学会賞
Association Membership(s) (3)：
日本生化学会 ,  日本分子生物学会 ,  日本免疫学会
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