Tsutsui Masato

ツツイマサト | Tsutsui Masato

Affiliation and department：
Homepage URL (1)： https://pharmaco.skr.u-ryukyu.ac.jp/

Research field (5)： Internal medicine - General , Respiratory medicine , Cardiology , Physiology , Pharmacology

Research keywords (10)：薬理学 , 創薬 , 医学 , 活性硫黄 , 遺伝子改変マウス , 呼吸器内科学 , 循環器内科学 , ガスバイオロジー , gene therapy , nitric oxide

Research theme for competitive and other funds (22)：

2024 - 2028 Integrated understanding of the mechanisms of maintenance and breakdown of epigenomic resilience for health
2022 - 2025 肺高血圧症に対するCARS2遺伝子治療法の確立
2018 - 2023 男性ホルモン補充に起因する虚血性心血管疾患に対する生体内NO量制御の有用性の検証
2019 - 2022 Elucidation of the role of the nitric oxide synthase system in the pathogenesis of respiratory diseases
2017 - 2019 Molecular mechanism of addiction to animal fat and therapeutic potential of brown rice-specific bioactive substance, gamma-oryzanol for animal fat preference

2015 - 2019 Elucidation of the exacerbation mechanisms of ischemic cardiovascular disease induced by testosterone.

2015 - 2018 An attempt to apply to new therapy the phenomenon that complete disruption of all nitric oxide synthase genes reduces cerebral infarct volume.

2015 - 2018 Role of dihydrofolate reductase in the regulation of endothelial function

2012 - 2015 Evaluation of the role of dihydrobiopterin in the regulation of endothelial function in the normal and pathological states

2011 - 2015 Increased motility of cancer cells through surface trafficking of GluR1 AMPA receptors by nitric oxide in response to ionizing radiation

2011 - 2014 Basic research on the role of the nitric oxide synthase system in organ connection

2008 - 2011 Elucidation of the significance of the nitric oxide synthase system in vivo by the use of mice lacking all nitric oxide synthases

2008 - 2010 Elucidation of pathophysiological significance of the nitric oxide synthase system in mice lacking all nitric oxide synthase isoforms

2008 - 2010 膀胱知覚および組織障害に対する一酸化窒素の役割

2006 - 2009 Gene Transfer of Human Extracellular Superoxide Dismutase Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats

2005 - 2008 Elucidation of roles of the nitric oxide synthase system on the basis of the development of mice lacing all nitric oxide synthase isoforms

2006 - 2007 Elucidation of the new role of nitric oxide in the cortical collecting duct that regulates and acid base balance

2004 - 2006 一酸化窒素合成酵素完全欠損マウスの開発

2004 - 2005 Asymmetricdimethylarginineの新規血管作用の解明

2004 - 2005 Genetic Possibility of neuronal nitric oxide synthase for kidney disease

2002 - 2003 Clarification of the mechanisms for vascular neuronal nitric oxide synthase expression

一酸化窒素合成酵素系(NOSs)の生物学的多様性の解明

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Papers (129)：

Mariana Gonçalves de Oliveira, José Britto-Junior, Douglas Rafael Martins Dias, Luise Gabriela Santos Pereira, Silvana Chiavegatto, Idam Hermawan, Hiroaki Shimokawa, Masato Tsutsui, Edson Antunes, Gilberto De Nucci. Neurogenic-derived 6-Nitrodopamine is the Most Potent Endogenous Modulator of the Mouse Urinary Bladder Relaxation. Nitric Oxide. 2024
Ogoshi T, Yatera K, Mukae H, Tsutsui M. Role of nitric oxide synthases in respiratory health and disease: insight from triple nitric oxide synthases knockout mice. Int J Mol Sci. 2024
Tsutsui M, Yatera K. Significance of nitric oxide derived from the nitric oxide synthases system in cardiovascular inter-organ cross-talk. J Pharmacol Exp Ther. 2024
Haruaki Kubota, Masato Tsutsui, Kanako Kuniyoshi, Hirotaka Yamashita, Hiroaki Shimokawa, Kazuhiro Sugahara, Manabu Kakinohana. Alleviated cerebral infarction in male mice lacking all nitric oxide synthase isoforms after middle cerebral artery occlusion. Journal of Anesthesia. 2023. 38. 1. 44-56
Hirotaka Yamashita, Hiroki Matsuhara, Hiroyuki Tanaka, Naoki Inagaki, Masato Tsutsui. Oral allergy induction through skin exposure to previously tolerated food antigens in murine models. Journal of Pharmacological Sciences. 2023. 152. 2. 76-85

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MISC (172)：

筒井正人, 喜多美香, 喜多美香, 坂梨まゆ子, 松崎俊博, 仲宗根淳子, 佐藤公雄, 下川宏明, 新崎章. 硝酸塩/亜硝酸塩の不足は代謝症候群,血管不全,心臓突然死を惹起する. 血管. 2018. 41. 1
筒井正人, 喜名美香, 喜名美香, 坂梨まゆ子, 松崎俊博, 仲宗根淳子, 佐藤公雄, 下川宏明, 新崎章. 硝酸塩/亜硝酸塩の不足は代謝症候群,血管不全,心臓突然死を惹起する. 日本酸化ストレス学会学術集会プログラム・抄録集. 2018. 71st
筒井正人, 下川宏明, 谷本昭英, 柳原延章, 尾辻豊. NOと代謝・循環器・腎臓疾患 NOSs完全欠損マウスの解析から. 腎臓内科・泌尿器科. 2017. 5. 2. 177-184
Yohei Satake, Kimio Satoh, Masamichi Nogi, Junichi Omura, Shigeo Godo, Satoshi Miyata, Hiroki Saito, Shuhei Tanaka, Yosuke Ikumi, Shinichi Yamashita, et al. Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice. American journal of physiology. Renal physiology. 2017. 312. 1. F33-F42
喜名美香, 坂梨まゆ子, 谷本昭英, 松崎俊博, 野口克彦, 仲宗根淳子, 下川宏明, 喜名振一郎, 砂川元, 大屋祐輔, et al. 食事中のnitriteおよびnitrateの不足は代謝症候群、内皮機能不全、および心血管死を惹起する. 血管. 2017. 40. 1. 60-60

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Education (2)：

1991 - 1995 University of Occupational and Environmental Health, Japan
1982 - 1988 University of Occupational and Environmental Health, Japan

Professional career (1)：

Doctor of Medical Sciences (University of Occupational and Environmental Health, Japan)

Work history (16)：

2021/04 - 現在琉球大学医学部長、琉球大学大学院医学研究科長(兼任)
2010/04 - 現在琉球大学大学院医学研究科薬理学教授
2018/04 - 2021/03 琉球大学医学部医学科長(兼任)
2017/04 - 2021/03 琉球大学医学部先端医学研究センター共通機器・RI研究支援分野長(兼任)
2015/04 - 2021/03 琉球大学医学部附属実験実習機器センター長(兼任)

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Committee career (16)：

2024/05 - 現在日本薬理学会財務委員会委員
2024/04 - 現在日本循環器学会九州支部代議員
2022/10 - 現在日本心脈管作動物質学会学会誌「血管」副編集長
2019/11 - 現在黒潮カンファレンス副理事長
2018/11 - 現在 Asian Society for Vascular Biology, Council Member

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Awards (14)：

2020/11 - Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award 2020
2019/11 - Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award 2019
2018/11 - Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award 2018
2017/11 - Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award 2017
2017/03 - Journal of Pharmacological Sciences, Excellent Reviewer Award

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Association Membership(s) (11)：

Asian Society for Vascular Biology , 黒潮カンファレンス , 日本臨床薬理学会 , 日本心脈管作動物質学会 , 日本NO学会 , American Physiological Society , American Heart Association , Japanese Association of Cardiovascular Pharmacology , 日本薬理学会 , 日本循環器学会 , 日本内科学会

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