Rchr
J-GLOBAL ID：200901080801705172
Update date: Mar. 22, 2023
Takashiba Shogo
タカシバ ショウゴ | Takashiba Shogo
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.cc.okayama-u.ac.jp/~perio/bind2/
Research field (2)：
Conservative dentistry and endodontics
, Conservative dentistry and endodontics
Research keywords (4)：
Endodontology
, Periodontology
, Dentistry
, Periodontal Science (Periodontology & Endodontology)
Research theme for competitive and other funds (86)：
- 2021 - 2025 細胞外小胞の口腔トロピズムを基軸とする侵襲性歯周炎の病態解明と診断への応用展開
- 2021 - 2024 プロトンポンプ阻害剤服用時に歯周病原細菌が腸内細菌叢へ及ぼす影響
- 2020 - 2023 APPLICATION OF RvD2 AS A REGENERATIVE DIRECT PULP CAPPING MATERIAL
- 2020 - 2023 歯周病原細菌の感染とタンパク質シトルリン化を介する関節リウマチの病態解明
- 2019 - 2023 Development of periodontal tissue regeneration therapy for horizontal alveolar bone resorption with collagen-binding FGF-2
- 2019 - 2022 超高齢社会での応用を目指す低分子化合物terreinの標的分子の同定・機能解析
- 2019 - 2022 フッ素による歯周病態のメタボリックコントロールを目指す基礎研究
- 2018 - 2021 末梢血単核球のミトコンドリア活性化を用いた新しい運動トレーニング評価法の開発
- 2018 - 2021 Biological effect and preventive method for human serum albumin binding to transboundary air borne PM2.5.
- 2018 - 2021 幹細胞ニッチの制御を目指したインテグリンペプチド療法の開発
- 2018 - 2021 Inflamm-agingを中心とした歯周病,サルコペニア,糖尿病の病態解明
- 2018 - 2021 Rothia mucilaginosa感染症の病因解明と感染コントロール法の確立
- 2016 - 2019 Application of anti-inflammatory small molecule compound, terrein and its novel analogue, for the treatment of endodontic or periodontal diseases.
- 2016 - 2018 Functional analysis of HMGB1 as an inflammatory mediator in periodontitis
- 2015 - 2018 Growth inhibition of selected bacterial species by peptide nucleic acids for control of oral microflora
- 2014 - 2017 Establishment of the concept of "febrile neutropenia caused by odontogenic infection" as periapical periodontitis
- 2014 - 2017 Induction of Migration of Periodontal Ligament Cells by Selective Regulation of Integrin Expression
- 2013 - 2017 An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis
- 2012 - 2015 Application of antisense PNA as antibiotics against periodontal pathogens
- 2013 - 2014 唾液腺体性幹細胞とiPS細胞を用いた唾液腺機能再生に関する研究
- 2012 - 2014 Cohort Study on the Relation between Infection of Periodontopahic Bacteria and Safety of Dental Implants
- 2011 - 2013 Construction of the prevention system of a Bisphosphonate-Related Osteonecrosis of the Jaw judging from an intraoral infection degree
- 2011 - 2013 Cell cycle atlas of periodontium
- 2010 - 2012 Investigation on the automation and speeding up ofmeasurement of the plasma IgG antibody titers against periodontopathic bacteria
- 2010 - 2012 How periodontitis can affect prostate cancer metastasis?
- 2010 - 2011 The molecular biological analysis of the mechanism for cell adhesion mediated by growth factor in human gingival epithelial cells
- 2009 - 2011 Chronic infection and immune response in COPD patients
- 2009 - 2011 Cross reactivity of archaeal chaperonin with human CCT involved in the pathogenesis of periodontitis and autoimmune disease
- 2008 - 2010 Healing mechanism of rat experimental periapical lesions targeting laminin γ2 expression
- 2008 - 2010 Possible Mechanisms of Progression of Periodontits by MMP-3 in Diabetic Patients
- 2008 - 2010 Investigation of the mechanisms of osteogenic differentiation by RhoA in periodontal ligament cells for cell transplantation
- 2007 - 2008 New bactericide delivery system for oral care
- 2007 - 2008 Molecular cloning and functional analysis of non-coding RNA expressed in periodontal bacteria
- 2007 - 2008 付着歯肉の分化に関連した特異的遺伝子・蛋白の同定とその機能解析
- 2006 - 2008 The wound healing mechanisms and regenerative therapy in dental pulp and periapical tissues
- 2006 - 2008 Mail Medicine using Fingertip Plasma for Screening and Monitoring Periodontitis
- 2005 - 2008 Establishment of Information Basis for Tooth Regeneration
- 2006 - 2007 マイクロバブルを用いた口腔嫌気性菌除去方法の検討
- 2005 - 2007 New Approach to the Study on Oral Biofilm Infectious Diseases by Metagenomic Analysis
- 2004 - 2007 Integrate research of genomics and proteomics of novel molecular targets for development of periodontal diseases cure
- 2005 - 2006 The effect on dentin-pulp complex by FIP-2 isolated from rat wounded pulp
- 2005 - 2006 カテプシン-Lプロモーターの薬剤応答配列を標的とした歯肉増殖症の治療法開発
- 2004 - 2006 A study of the healing mechanisms of destructive periapical lesions and regenerative medicine for periapical bone defect
- 2004 - 2006 Diagnostic approaches by a susceptibility determination based on gene polymorphism in Japanese periodontitis patients.
- 2004 - 2006 Preparation of self-organized nano-structured apatite and the protein adsorption property
- 2003 - 2006 X-ray Crystal Structural Analysis of Bacterial Iron Binding Protein and Development for New Antibiotics
- 2005 - 2005 歯周病細菌に対する血清抗体価測定法の標準化に関する調査研究
- 2004 - 2005 バイオフィルムにおける歯周病細菌病原因子発現様態のゲノム-プロテオミクス解析
- 2002 - 2005 Gene Therapy for Periodontal Diseases -Regulation of host response by local gene delivery-
- 2004 - 2004 歯周靭帯細胞における機械的ストレス応答性遺伝子のグルーピングと転写機構
- 2003 - 2004 Regulation of gene expression of periodontal virulence factors during biofilm formation
- 2003 - 2004 Gene profiling of periodontal pathogens in periodontal lesion
- 2003 - 2004 日本人の腎結石から分離した新種ナノバクテリアに関する多面的解析
- 2003 - 2004 口腔インプラントの骨結合獲得難易度を予測する生物学的診断法の開発
- 2002 - 2004 Establishment of a autologous cell transplantion method using mesenchymal stem cells for perio-dontal tissue and alveolus bone regeneration.
- 2002 - 2003 Development of the methods for application of the factors that biologically accelerate reparative dentin formation
- 2002 - 2003 Role of a novel transcription factor for TNF-α, LITAF, on the pathogenesis of periodontitis
- 2002 - 2003 歯周病原性細菌によって起こる誤嚥性肺炎の分子免疫学的病態の研究
- 2000 - 2003 Project study of tissue regeneration with tissue engineering
- 2001 - 2002 歯周組織の治癒に関わる遺伝子の研究
- 2000 - 2002 Study on the influence of periapical lesions on systemic health
- 2000 - 2001 Molecular cloning of the factors that biologically accelerate reparative dentin formation
- 2000 - 2001 Periodontal Treatment by Regulation of Novel TNF-α Transcription Factor in Monocytes
- 2000 - 2001 Microbiological examination for periodontal therapy
- 2000 - 2001 Factor for induction of root resorption
- 2000 - 2001 歯周病の発症と進行に関わる交叉免疫応答を誘導する抗原蛋白
- 1999 - 2001 Study for preservation of dentin using local gene deliveryof dentin-specific genes
- 2000 - 2000 早期発症型歯周炎の病態解析と診断基準確立に向けた共同研究の企画調査
- 1999 - 2000 上皮由来抗菌ペプチドの利用による歯周病原性細菌の感染予防にむけて
- 1998 - 1999 The diversified research on. the genes related periodontal disease
- 1998 - 1999 Study on the pathogenesis of periodontal disease in patients with Down's syndrome
- 1998 - 1999 Studies on bone regeneration by application of osteoblast differentiation marker, Cbfal, gene products
- 1997 - 1999 Study of Periodontal Tissue Reconstruction using Various Growth Factors
- 1997 - 1999 Differentiation from dental pulp cells to odontoblasts and calcification of the pulp.
- 1997 - 1998 Basic studies on adaptation the immune therapy to the patients with periodontal diseases by using synthetic peptides as an immunogen
- 1997 - 1998 Studies on differentiation and proliferation factors for induction of biological reparative dentin formation
- 1996 - 1998 Study on the control of periodontal ligament fibroblast functions by transforming growth factor
- 1997 - 1997 L-セレクチンを介したβ_2-インテグリンのシグナル伝達機構から捉える歯周病病態
- 1996 - 1997 Regulation of osteogenic function of periodontal ligament fibroblast by 1d, 25-dihydroxy vitamin D3 receptor inducing factor.
- 1996 - Molecular biological study on tissue regeneration
- 1994 - 1995 Analyzes of periodontitis status from changes in gingival fibroblasts subpopulation
- 1994 - 1995 Molecular biological study on the IL-8 production in inflamed gingiva
- 1991 - 1993 Molecular Basis of Leukocyte Adhesion Molecules in Early-onset Periodontitis Patients.
- 1992 - Study on molecular pathogenesis of inflammation
- 1991 - 1991 歯周病患者に検出されたHLA遺伝子変異の解析
- Study on genetics of periodontal diseases
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Papers (216)：
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Hidefumi Sako, Kazuhiro Omori, Masaaki Nakayama, Hiroki Mandai, Hidetaka Ideguchi, Saki Yoshimura-Nakagawa, Kyosuke Sakaida, Chiaki Nagata-Kamei, Hiroya Kobayashi, Satoki Ishii, et al. The Fungal Metabolite (+)-Terrein Abrogates Inflammatory Bone Resorption via the Suppression of TNF-α Production in a Ligature-Induced Periodontitis Mouse Model. Journal of Fungi. 2023. 9. 3. 314-314
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Xiaoting Chen, Zulema Arias, Kazuhiro Omori, Tadashi Yamamoto, Yuki Shinoda-Ito, Shogo Takashiba. Autophagy as a potential mechanism underlying the biological effect of 1,25-Dihydroxyvitamin D3 on periodontitis: a narrative review. BMC oral health. 2023. 23. 1. 90-90
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Kazuhiro Omori, Norihisa Toh, Hidetaka Ideguchi, Kentaro Okamoto, Hidefumi Sako, Kanako Kodam, Tadashi Yamamoto, Teiji Akagi, Shingo Kasahara, Hiroshi Ito, et al. A case report of bacteremia caused by dental endodontic treatment in a patient with single ventricle. 2023. 12. 2. 1-8
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Zulema Arias, Heber Falú Hinojosa Ledezma, Claudia Patricia Osorio Terán, Kazuhiro Omori, Tadashi Yamamoto, Mohammed Zahedul Islam Nizami, Shogo Takashiba. Reattachment of Fractured Tooth Fragment by Multidisciplinary Treatment Approach. The Bulletin of Tokyo Dental College. 2023
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Mohammed Zahedul Islam Nizami, Melahat Gorduysus, Yuki Shinoda-Ito, Tadashi Yamamoto, Yuta Nishina, Shogo Takashiba, Zulema Arias. Graphene Oxide-based Endodontic Sealer: An in Vitro Study. Acta medica Okayama. 2022. 76. 6. 715-721
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MISC (754)：
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高柴 正悟. 歯科から未病化への展望 未病化への歯科貢献を考える. 日本未病学会学術総会抄録集. 2022. 29回. 61-61
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釜田 英幸, 畑中 加珠, 小山 芳伸, 山本 直史, 高柴 正悟. 関節リウマチ患者の治療反応性に対する歯周病感染の影響と新たな医科歯科連携の提案. 日本未病学会学術総会抄録集. 2022. 29回. 74-74
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久保田 萌可, 大森 一弘, 杜 徳尚, 佐光 秀文, 井手口 英隆, 岡本 憲太郎, 山本 直史, 赤木 禎治, 笠原 真悟, 伊藤 浩, et al. 歯科治療に起因する感染性心内膜炎の発症予防を目指す岡山大学病院成人先天性心疾患センターの取り組み. 日本未病学会学術総会抄録集. 2022. 29回. 75-75
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高柴 正悟. 【歯周病が及ぼす全身疾患への影響】歯周病の要因および全身疾患との関連 歯周病と肺炎. 診断と治療. 2022. 110. 9. 1159-1163
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松田 真司, 菅谷 勉, 加藤 幸紀, 根本 英二, 竹内 康雄, 喜田 大智, 沼部 幸博, 西田 哲也, 小方 頼昌, 申 基哲, et al. 全身性疾患への影響を考慮した新たな歯周病重症度検査項目の策定 学会主導型多施設臨床研究. 日本歯周病学会会誌. 2022. 64. 秋季特別. 112-112
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Patents (15)：
Books (37)：
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歯周病患者における抗菌薬適正使用のガイドライン2020
日本歯周病学会 2020
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歯周病と全身の健康
(NPO) 日本歯周病学会 2016
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腸内細菌・口腔細菌と全身疾患
シーエムシー出版 2015
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最新歯科衛生士教本 歯周病学 第2版
医歯薬出版 2015
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感染していることがわかった患者への対応(第2部歯科医院に勧める効果的な「院内感染」対策),患者が求める「医療安全」「院内感染」対策
ヒョーロン・パブリッシャーズ 2014
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Lectures and oral presentations (303)：
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Personalized Pre-Clinical Dental Education to Address Covid-19 Pandemic Impact
(2022 IADR/APR General Session (Virtual) 2022)
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Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects Against Streptococcus Mutans
(2022 IADR/APR General Session (Virtual) 2022)
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HMGB1 Accelerates Acute Phase Periodontitis by Regulating Macrophage Polarization
(2022 IADR/APR General Session (Virtual) 2022)
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Collagen-Binding Basic Fibroblast Growth Factor Promotes Horizontal Periodontal Regeneration
(2021 IADR/AADR/CADR General Session (Virtual) 2021)
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Resolvin D2 Promotes the Formation of Calcified Tissue on Pulp
(2021 IADR/AADR/CADR General Session (Virtual) 2021)
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Works (2)：
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BioJapan 2019
高柴正悟 2019 - 2019
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アカデミック フォーラム(第7回 化粧品開発展)
2017 -
Education (2)：
- 1986 - 1990 Okayama University Graduate School of Dentistry
- 1980 - 1986 Okayama University Dental School School of Dentistry
Professional career (2)：
- Ph.D. (Okayama University)
- D.D.S. (Okayama University)
Work history (9)：
- 2021/04 - 現在 Okayama University Professor
- 2005/04 - 2021/03 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Periodontal Science Professor
- 2002/04 - 2005/03 Okayama University Graduate School of Medicine and Dentistry, Periodontal Science Professor
- 2001/04 - 2002/03 Okayama University Graduate School of Medicine and Dentistry, Periodontal Science Associate Professor
- 1995/11 - 2001/03 Okayama University Dental School Associate Professor
- 1996/02 - 1996/04 文部科学省在外研究員(University of Southern California & National Institute of Dental and Craniofacial Research, USA)
- 1994/12 - 1995/11 Okayama University Dental School Assistant Professor
- 1992/04 - 1994/11 Eastman Dental Center (Rochester, NY, USA) Periodontology (Prof. Van Dyke Lab) Visiting Scientist
- 1990/04 - 1992/03 Okayama University University Hospital of Dentistry Assistant Professor
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Committee career (22)：
- 2021/07 - 現在 International Association for Dental Research President of Periodontal Research Group
- 2020 - 現在 日本未病学会 理事
- 2017/01 - 現在 International Academy of Periodontology Board Menber
- 2017 - 現在 日本予防医学会 理事
- 2011 - 現在 日本口腔検査学会 理事
- 2002/04 - 現在 日本歯周病学会 理事
- 2002/04 - 現在 岡山歯学会 理事
- 2002/04 - 現在 日本歯科保存学会 理事
- 2019/01 - 2021/12 International Association for Dental Research Editorial Board Member
- 2020/03 - 2021/07 International Association for Dental Research President Elect of Periodontal Research Group
- 2019/04 - 2021/03 日本歯周病学会 常任理事,学会あり方委員会委員長
- 2017/04 - 2021/03 日本歯科保存学会 常任理事,医療合理化委員会委員長
- 2019/03 - 2020/03 International Association for Dental Research Vice President of Periodontal Research Group
- 2017/04 - 2019/03 日本歯周病学会 常任理事,専門医委員会医員長
- 2019 - 日本未病システム学会 理事
- 2006 - 2018 日本未病システム学会 評議員
- 2011/04 - 2015/03 日本歯周病学会 常任理事,研究委員会医員長
- 2009/04 - 2011/03 日本歯周病学会 常任理事,用語委員会委員長
- 2007/04 - 2010/03 日本歯科保存学会 常任理事,編集委員会委員長
- 2009 - 日本歯周病学会 2009年(第52回)春季日本歯周病学会 学術大会大会長
- 2001/01 - 2004/12 International Association for Dental Research Editorial Board Member
- 2000/01 - 2004/12 International Association for Dental Research Abstract Reviewer (Periodontal Research Group)
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Awards (9)：
- 2021/07 - International Association for Dental Research 2021 IADR/AADR William J. Gies Award in Biomaterials and Bioengineering Research "Functionalized Graphene Oxide Shields Tooth Dentin from Decalcification" in Journal of Dental Research, 2020 Feb;99(2):182-188.
- 2010 - 第17回日本未病システム学会学術総会研究奨励賞
- 2009 - 米国歯周病学会(AAP)R. Earl Robinson Periodontal Regeneration Award
- 2001 - 第一回 日本歯周病学会学術賞
- 1997 - Hatton Awards Nominee Division Travel Award
- 1997 - 第19回両備園記念財団研究助成
- 1997 - 第75回国際歯科研究学会トラベル賞 (1997 IADR Unilever Travel Award)
- 1995 - 第3回小林孫兵衛記念医学振興財団研究助成
- 1995 - 第5回国際歯周病学会研究部門賞(グループ受賞)(The first place of AWARD in research section of 5th meeting of International Academy of Periodontology)
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Association Membership(s) (14)：
日本予防医学会
, 日本医療情報学会
, 日本歯内療法学会
, 日本未病学会
, 日本口腔検査学会
, American Society for Microbiology
, International Academy of Periodontology
, 日本炎症・再生医学会
, Japanese Association for Dental Research
, 日本免疫学会
, International Association for Dental Research
, 岡山歯学会
, 日本歯周病学会
, 日本歯科保存学会
