Research theme for competitive and other funds (4):
2017 - 2020 Comprehensive identification of amino acid residues that participate in increasing activity of carbapenemase and anapysis of structural transition of those enzymes
2017 - 2020 酸化ストレスに対する防御機能を有する人工赤血球製剤の創製と体内評価
2013 - 2017 臨床解析と分子細菌学的手法による敗血症発症因子の解明と予測法の確立
2013 - 2016 Analysis of enlargement mechanism of substrate specificity of CTX-type beta-lactamase using structural data
Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai. Quantification of hybrid a2b2 tetramer formed by spontaneous exchange of dimer ab subunits between PEGylated and native hemoglobins using intra-molecular cross-linking. XVII-ISBS-2019. 2019. 147-147
Magohei Yamada, Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai. A hidden cooperative function of NAD(P)H and HbO2 for suppressing metHb formation and elucidation of its pseudo-enzymatic mechanism. XVII-ISBS-2019. 2019. 139-139
Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai. Supramolecular ring-opening polymerization of hemoglobin and subsequent fixation using site-specific cross-linking within a2b2 tetramers. XVII-ISBS-2019. 2019. 105-105
Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai. Covalent fixing of supramolecular hemoglobin polymer using site-selective intra-molecular subunit crosslinking. 15th International Symposium on Applied Bioinorganic Chemistry. 2019