keizo yamamoto

ヤマモトケイゾウ | keizo yamamoto

Affiliation and department：
Job title： Associate Professor

Research field (1)： Structural biochemistry

Research keywords (4)：蛋白質進化 , βーラクタマーゼ , 糖質関連酵素 , X-ray crystallography

Research theme for competitive and other funds (6)：

2021 - 2024 Resuscitation from hemorrhagic shock by carbon monoxide- and oxygen-carrying capacities of artificial red cells.
2021 - 2024 Structural analysis of IMP-type metallo-beta-lactamase in complex with its substrate
2017 - 2020 Comprehensive identification of amino acid residues that participate in increasing activity of carbapenemase and anapysis of structural transition of those enzymes
2017 - 2020 酸化ストレスに対する防御機能を有する人工赤血球製剤の創製と体内評価
2013 - 2017 臨床解析と分子細菌学的手法による敗血症発症因子の解明と予測法の確立

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Papers (50)：

Keizo Yamamoto, Hideaki Tanaka, Genji Kurisu, Ryuichi Nakano, Hisakazu Yano, Hiromi Sakai. Structural insights into the substrate specificity of IMP-6 and IMP-1 metallo-β-lactamases. Journal of biochemistry. 2023. 173. 1. 21-30
松平崇, 山本惠三, 酒井宏水. 超分子重合を利用した人工酸素運搬体の構築. 人工血液. 2021. 29. 1. 50-56
山田孫平, 松平崇, 山本惠三, 酒井宏水. NADHとヘモグロビンの共存による抗酸化的な擬似酵素活性と人工赤血球への応用. 人工血液. 2020. 28. 1. 49-56
Matsuhira T, Yamamoto K, Sakai H. Ring-Opening Polymerization of Hemoglobin. Biomacromolecules. 2019. 20. 4. 1592-1602
Yamada M, Matsuhira T, Yamamoto K, Sakai H. Antioxidative Pseudoenzymatic Mechanism of NAD(P)H Coexisting with Oxyhemoglobin for Suppressed Methemoglobin Formation. Biochemistry. 2019. 58. 10. 1400-1410

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MISC (32)：

Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai. Quantification of hybrid a2b2 tetramer formed by spontaneous exchange of dimer ab subunits between PEGylated and native hemoglobins using intra-molecular cross-linking. XVII-ISBS-2019. 2019. 147-147
Magohei Yamada, Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai. A hidden cooperative function of NAD(P)H and HbO2 for suppressing metHb formation and elucidation of its pseudo-enzymatic mechanism. XVII-ISBS-2019. 2019. 139-139
Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai. Supramolecular ring-opening polymerization of hemoglobin and subsequent fixation using site-specific cross-linking within a2b2 tetramers. XVII-ISBS-2019. 2019. 105-105
Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai. Covalent fixing of supramolecular hemoglobin polymer using site-selective intra-molecular subunit crosslinking. 15th International Symposium on Applied Bioinorganic Chemistry. 2019
大﨑茂芳, 山本惠三, 山戸一弘. ミノムシの命綱の力学強度は重い蓑に影響されるのか?. 高分子学会予稿集. 2019. 68. 1

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Patents (2)：

Books (1)：

Nanobiotherapeutic based blood substitutes
World Scientific Pub. 2022 ISBN:9789811228681

Education (2)：

Professional career (2)：

Work history (6)：

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Committee career (2)：

Association Membership(s) (6)：

高分子学会 , 日本臨床微生物学会 , 日本応用糖質科学会 , 日本農芸化学会 , 日本結晶学会 , 日本生物工学会

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