Yokote Koutaro

2017 - 2020 Elucidation of molecular pathology of aging and diseases based on multi-dimensional analysis of progeroid syndromes

2017 - 2020 Discovery of novel progeroid syndrome loci and contribution to normative aging

2017 - 2019 Cell Therapy on Chronic Kidney Diseases by Inducible Podocytes from Somatic Cells

2016 - 2019 Pathological analysis and therapeutic development for Werner syndrome by disease-specific iPS cells.

2016 - 2019 Functional analysis of R3h domain containing-like, a novel skeletal satellite-cell-expressed gene, for investigating new treatment strategy of sarcopenia

2015 - 2019 The development of quality indicators and the building of a system pertaining to continuation and collaboration in the field of elderly care

2015 - 2019 Elucidation of the transformation mechanisms of a cognitive function and activity in brain reward prcessing after bariatric surgery in obesity

2014 - 2019 Understanding of stem cell aging as the onset basis of hematopoietic tumors in elderly patients

2014 - 2017 Pathological elucidation of age-related diseases by integrative analyses of senescence genes

2014 - 2017 Analysis of the mechanism of myelofibrosis with Smad3 knock out mice

2014 - 2016 The role of Semaphorin signaling in pathogenesis of obesity and fatty liver -possible implication of gastrointestinal biota.

2011 - 2015 Investigation of the mechanism of lifestyle-related diseases through the functional analysis of Semaphorin 3G, with the goal of developing a novel biomarker.

2012 - 2014 Establishment of disease iPS cells and molecular analysis of age-related changes in progeroid syndrome

2011 - 2014 The role of lymphatic system and its functional failure in development of metabolic disorders.

2008 - 2010 Functional analysis of a novel glomerular specific gene and its application in the treatment of diabetic nephropathy.

2008 - 2010 Functional analysis of CCN3, a novel growth inhibitor for vascular smooth muscle cells, and its application in the treatment of vascular diseases.

2006 - 2007 Anti-atherosclerotic factors induced by Smad signaling in vascular cells

2004 - 2005 Novel therapeutical approach against atherosclerosis through modification of TGF-β signal in vascular

2002 - 2003 VASCULAR REMODELING BY TARGETED DISRUPTION OF TGF-β SIGNAL.

2001 - 2001 ヘキソサミン経路を介し糖尿病合併症の発症に関わる遺伝子群の同定と調節機構の解明

2001 - 2001 がんを好発するSmad3欠損マウスを用いたTGF-β作用に関する血管生物学的解析

2000 - 2001 ヘキソサミン経路を介する遺伝子発現賦活機序の解明と糖尿病性大血管障害抑制への応用

1998 - 1998 血小板由来増殖因子受容体細胞内シグナル伝達機構の解析