Rchr
J-GLOBAL ID：200901081803394944   Update date: Jul. 29, 2024

Kato Hiroaki

カトウ ヒロアキ | Kato Hiroaki
Affiliation and department：
Kyoto University Graduate School of Pharmaceutical Sciences, Division of Physical and Organic Chemistry, Structural Biology

About Kyoto University Graduate School of Pharmaceutical Sciences, Division of Physical and Organic Chemistry, Structural Biology


Job title： Professor
Homepage URL  (1)： http://www.pharm.kyoto-u.ac.jp/kato/index.html
Research field  (4)： Biophysics ,  Structural biochemistry ,  Pharmaceuticals - analytical and physicochemistry ,  Applied biochemistry
Research keywords  (4)： Basic medical sciences ,  Structural pharmacology ,  Structural Biology ,  Stractural Biology
Research theme for competitive and other funds  (55)：
  • 2024 - 2027 Structural basis of diversed and dynamic substrate recognition mechanism of multidrug transporter by chemical trapping
  • 2021 - 2023 Structural biology studies on the effect of phospholipid contents for multi-drug transporters
  • 2020 - 2023 Structural basis for alternating access mechanism of ABC multi-drug pump in lipid membrane
  • 2019 - 2021 Structural basis for discrimination between multi-drug exporters and lipid floppies
  • 2017 - 2020 Mechanism of contraction and backflow prevention by check valves in ABC transporter pump
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Papers (140)：
  • Sorachi Miwa, Hiroshi Takikawa, Rina Takeuchi, Ryo Mizunuma, Keita Matsuoka, Haruo Ogawa, Hiroaki Kato, Kiyosei Takasu. Structure-ATPase Activity Relationship of Rhodamine Derivatives as Potent Inhibitors of P-Glycoprotein CmABCB1. ACS medicinal chemistry letters. 2024. 15. 2. 287-293
  • Hiroaki Kato. [The First 5-year Integrated Doctoral Program Exploring the Frontiers of Pharmaceutical Sciences]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2023. 143. 10. 827-834
  • Yoshiki Inoue, Tomohiro Yamaguchi, Tetsuo Otsuka, Yuto Utsunomiya, Dongqing Pan, Haruo Ogawa, Hiroaki Kato. Structure-based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy. Protein Science. 2022. 31. 6. e4331
  • Dongqing Pan, Ryo Oyama, Tomomi Sato, Takanori Nakane, Ryo Mizunuma, Keita Matsuoka, Yasumasa Joti, Kensuke Tono, Eriko Nango, So Iwata, et al. Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX. IUCrJ. 2022. 9. 1. 134-145
  • Keita Matsuoka, Toru Nakatsu, Hiroaki Kato. The crystal structure of the CmABCB1 G132V mutant, which favors the outward-facing state, reveals the mechanism of the pivotal joint between TM1 and TM3. Protein Science. 2021. 30. 5. 1064-1071
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MISC (290)：
  • 加藤 博章. 物理系薬学部会:薬学の基礎から応用までを網羅する科学研究コミュニティ. ファルマシア. 2023. 59. 4. 282-284
  • 大鳥祐矢, 加藤博章, 加藤博章, 小川治夫. 心筋型リアノジン受容体の構造解析-カフェインによる活性化機構の解明に向けて. 次世代を担う若手のためのフィジカル・ファーマフォーラム講演要旨集. 2023. 20th
  • 中津亨, 田中義明, 加藤博章. X-ray Crystallographic Analysis of Luciferase:oxyakalumine:AMP Complex. SPring-8/SACLA利用研究成果集(Web). 2023. 11. 5
  • 近藤瞳, 児玉昌美, 加藤博章, 加藤博章, 小川治夫. クライオ電顕による一回膜貫通型受容体NPR-Bの機能構造解析. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2023. 44th
  • 相良優介, 水沼諒, 小川治夫, 加藤博章, 加藤博章. Drug-binding affinity of ABC transporter in phospholipid bilayer or detergent micelle. 日本薬学会年会要旨集(Web). 2023. 143rd
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Patents (1)：
Books (10)：
  • Peroxisomes: Biogenesis, function, and role in human disease
    Springer Nature Singapore 2019 ISBN:9789811511684
  • Works of researchers who invent medicines
    KAGAKUDOJIN 2017
  • 日本薬学会編物理系薬学III.機器分析・構造決定
    東京化学同人 2016
  • ナノバイオ技術と最新創薬応用研究 (橋田 充, 佐治英郎 編)
    遺伝子医学MOOK 2012
  • 現代生物科学入門3構造機能生物学「時計制御構造生物学」
    岩波書店 2011
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Lectures and oral presentations  (17)：
  • X-Ray Structures of CmABCB1 in outward- and inward-facing states reveal a conformational exchange allowing the efflux of multi drug
    (7th FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases 2018)
  • Recognition mechanism of the second peroxisomal targeting signal, PTS2 by its receptor complex Pex7p and Pex21p
    (Consortium of Biological Sciences 2017 (ConBio2017) 2017)
  • How ATP binding cassette (ABC) transporter harnesses the energy of ATP binding and hydrolysis to multi drug export
    (The 55th Annual Meeting of the Biophysical Society of Japan 2017)
  • P糖タンパク質のメカニズムから薬物動態の分子構造基盤をさぐる
    (フォーラム富山「創薬」第45回研究会 2017)
  • Recognition mechanism of the second peroxisomal targeting signal, PTS2 by its receptor complex Pex7p and Pex21p
    (2nd International Conference "Peroxisome Function, Function and Metabolism" 2016)
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Works (12)：
  • 第三世代シンクロトン放射光を用いた酵素の極限状態X線結晶構造解析
    2001 - 2003
  • 新たな膜輸送機構の分子基盤
    2003 -
  • 生理活性糖鎖の構造的基盤と高次生命機能の制御
    2003 -
  • 藍色細菌の生物時計装置の原子レベルでの解明
    2003 -
  • 超高分解能X線構造解析に基づくエンドポリガラツクロナーゼの反応機構の解明
    2003 -
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Education (3)：
  • 1985 - 1988 Kyoto University Graduate School of Agriculture
  • 1983 - 1985 Yamagata University Graduate School of Agricultual Sciences-Masters Program
  • 1979 - 1983 Yamagata University Faculty of Agriculture Department of Agricultural Chemistry
Professional career (2)：
  • Doctor of Agriculture (Kyoto University)
  • Master of Agriculture (Yamagata University)
Work history (6)：
  • 2002/04 - 現在 京都大学大学院薬学研究科、教授
  • 2002/04 - 2006/03 チームリーダーを兼任
  • 1999/10 - 2006/03 理化学研究所・速度論的結晶学研究チーム・チームリーダー
  • 1989 - 1999/09 同大学文部教官 助手
  • 1988/05 - 1989/02 Kyoto University Institute for Chemical Research
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Awards (1)：
  • 1994 - 日本農芸化学会奨励賞受賞
Association Membership(s) (3)：
日本薬学会 ,  日本生物物理学会会員 日本蛋白質科学会会員 ,  日本結晶学会会員 日本分子生物学会会員 日本農芸化学会会員
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