Rchr
J-GLOBAL ID:200901081913306897
Update date: Nov. 30, 2024
Hijiya Naoki
ヒジヤ ナオキ | Hijiya Naoki
Affiliation and department:
Job title:
Assistant Professor,Assistant Professor
Homepage URL (1):
http://www.med.oita-u.ac.jp/byori2/index.htm
Research field (2):
Experimental pathology
, Human pathology
Research keywords (4):
人体病理学
, 実験病理学
, Surgical Pathology
, Experimental Pathology
Research theme for competitive and other funds (34):
- 2024 - 2028 Development of new diagnostic and therapeutic strategies targeting the molecular basis contributing to invasion of pancreatic cancer
- 2024 - 2027 Development of a new therapeutic strategy targeting Clusterin, a molecule associated with treatment resistance in pancreatic cancer
- 2023 - 2026 大腸癌の新規がん遺伝子VSNL-1の機能解明と臨床応用
- 2023 - 2026 Elucidation of stromal changes in pancreatic cancer caused by neoadjuvant chemotherapy and establishment of new treatment
- 2023 - 2026 膵癌の浸潤に関与する新規がん抑制遺伝子PLEKHA2の機能解明と治療応用
- 2023 - 2026 胆汁由来オルガノイドを用いた胆道癌の病態解明と治療標的の同定
- 2024 - 2025 核タンパク質リン酸化プロテオミクスを用いた新規抗癌剤効果予測因子と治療標的の探索
- 2021 - 2025 Screening of biomarkers and targets for cancer therapy by nuclear phosphoproteomics
- 2021 - 2024 オルガノイド樹立による大腸粘液癌の病態解明と治療標的の同定
- 2021 - 2024 「がん遺伝子DUSP4」の新規基質同定と治療応用
- 2020 - 2023 Functional analysis and therapeutic application of clusterin, a candidate gene involved in resistance to anticancer agents in cholangiocarcinoma
- 2019 - 2022 Development and therapeutic application of model mice harboring genomic alterations in human pancreatic cancers
- 2018 - 2021 Prediction of drug efficacy by patients derived tumor organoids (PDOs) and early response markers (ERMs)
- 2017 - 2020 Clarification of the functional significance of DUSP4 and its therapeutic application in colorectal cancers.
- 2017 - 2020 The functional analyses and the therapeutic applications of a novel tumor suppressor gene ZNF395 involved in the progression of pancreatic cancers.
- 2016 - 2019 To identify intestinal flora composition involved in the development and progression of colorectal cancer
- 2016 - 2019 Functional analyses and therapeutic application of novel tumor suppressor gene DUSP4 involved in invasion of pancreatic cancer
- 2013 - 2016 Functional analysis and therapeutic application of cannabinoid receptor in esophageal carcinoma.
- 2010 - 2013 膵癌前駆病変の悪性化に関わる第8番染色体短腕上の責任遺伝子の同定
- 2010 - 2012 Identification of the responsible genes on 8p involved in themalignant transformation of the precancerous lesions in the pancreas .
- 2007 - 2009 リン酸化EGFR抗体を用いた肺癌のGefitinib感受性診断法の確立
- 2006 - 2008 骨格筋特異的アンキリン蛋白質ARPPによる脂肪酸の細胞内取り込み制御機構の解析
- 2007 - 2008 Establishment of the diagnostic method using antibody against phosphorylated EGFR for responsiveness to gefitinib therapy of lung cancer patients
- 2005 - 2007 萎縮骨格筋で発現誘導する筋特異的蛋白質ARPPの機能解析
- 2006 - 2007 Fumctional analysis of AEPP in skeletal muscle
- 2004 - 2006 インスリンによるグルコースの細胞内取り込みを制御する新規蛋白質ARPPの機能解析
- 2005 - 2006 Functional analysis of muscle-specific protein, ARPP, expressed in the atrophic skeletal muscles
- 2004 - 2005 Functional analysis of ARPP protein in the regulation of insulin-dependent glucose uptake
- 1999 - 2004 ADAMファミリーメンバーのクローニングと機能解析
- 1999 - 2003 ADAMファミリーメンバーのクローニングと機能解析
- 1999 - 2001 細菌感染におけるCD14の意義と初期シグナル伝達分子の検索および制御
- 1999 - 2000 Role of CD14 in bacterial infection, and search and regulation of molecules in early signal transduction
- Establishment of useful method for predicting the responsiveness of pulmonary adenocarcinomas to gefitinib
- Identification and functional analysis of genes involved in pancreatic carcinogenesis
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Papers (94):
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平下 有香, 塚本 善之, 泥谷 直樹, 小坂 聡太郎, 高橋 晴彦, 福田 健介, 岡本 和久, 小川 竜, 水上 一弘, 兒玉 雅明, et al. 胆汁酸はERKシグナル伝達経路を介し化生変化を誘導する. 日本胃癌学会総会記事. 2024. 96回. 377-377
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Yu Wang, Shunsuke Shimosaki, Emi Ikebe, Hidekatsu Iha, Jun-ichi Yamamoto, Nichole Fife, Tomonaga Ichikawa, Mitsuo Hori, Masao Ogata, Yoshiyuki Tsukamoto, et al. IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors. Frontiers in Oncology. 2024. 13
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Takafumi Fuchino, Shusaku Kurogi, Yoshiyuki Tsukamoto (corresponding author, Tomotaka Shibata, Shoichi Fumoto, Hajime Fujishima, Keisuke Kinoshita, Yuka Hirashita, Masahide Fukuda, Chisato Nakada, et al. Characterization of residual cancer by comparison of a pair of organoids established from a patient with esophageal squamous cell carcinoma before and after neoadjuvant chemotherapy. Human Cell. 2024
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Takayuki Aiba, Naoki Hijiya, Tomonori Akagi, Yoshiyuki Tsukamoto, Yuka Hirashita, Keisuke Kinoshita, Tomohisa Uchida, Chisato Nakada, Shusaku Kurogi, Yoshitake Ueda, et al. Overexpression of VSNL1 enhances cell proliferation in colorectal carcinogenesis. Pathobiology : journal of immunopathology, molecular and cellular biology. 2023
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Yoshiyuki Tsukamoto, Shusaku Kurogi, Hajime Fujishima, Tomotaka Shibata, Shoichi Fumoto, Kohei Nishiki, Kosuke Suzuki, Tsuyoshi Etoh, Norio Shiraishi, Takafumi Fuchino, et al. Association of immune-related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma. Cancer science. 2023
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MISC (34):
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中田知里, 白石裕士, 池内真代, 池内真代, 清水誠之, 浜松典子, 塚本善之, 泥谷直樹, 安藤忠助, 花田俊勝, et al. 腎淡明細胞癌で異常発現するmiR-210の生物学的機能の解析. 泌尿器科分子・細胞研究会プログラム・抄録集. 2024. 33rd
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泥谷直樹, 塚本善之, 黒木秀作, 中田知里, 守山正胤. Clusterin is involved in the refractory response of pancreatic cancer cells to a MAP kinase inhibitor. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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黒木秀作, 泥谷直樹, 塚本善之, 中田知里, 猪股雅史, 小林隆志, 守山正胤. ANXA8 is involved in the resistance to MAPK inhibitor in pancreatic cancer. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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塚本善之, 渕野貴文, 黒木秀作, 柴田智隆, 藤島紀, 板井勇介, 麓祥一, 猪股雅史, 村上和成, 泥谷直樹. 術前化学療法の効果が低かった食道癌1例の化学療法前・後から樹立した癌オルガノイドの解析. 日本ヒト細胞学会学術集会. 2023. 41st
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Shusaku Kurogi, Naoki Hijiya, Yoshiyuki Tsukamoto, Chisato Nakada, Masafumi Inomata, Takashi Kobayashi, Masatsugu Moriyama. Downregulation of ZNF395 enhances cell proliferation in pancreatic ductal adenocarcinoma through inactivation of JNK. CANCER SCIENCE. 2022. 113. 567-567
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Books (1):
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Role of CD14 in infection : studies in CD14-deficient mice Endotoxin and sepsis molecular mechanisms of pathagenesis, host resistance and therapy
Wiley-Liss 1998
Professional career (1):
Association Membership(s) (3):
日本癌学会
, 日本病理学会
, 日本分子生物学会
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