Shimoyama Atsushi

シモヤマアツシ | Shimoyama Atsushi

Affiliation and department：
Job title： Associate Professor

Research field (2)： Bioorganic chemistry , Molecular biochemistry

Research keywords (11)： Peptidoglycan , Vaccine Adjuvant , Symbiotic Bacteria , Sugar Mimic , Lipid A , Organic Synthetic Chemistry , Natural Product Chemistry , Chemical Ecology , Lipopolysaccharide , Innate Immunity , Chemical Biology

Research theme for competitive and other funds (17)：

2023 - 2027 金ナノ粒子を核としたアルファ線による新しい悪性腫瘍治療法の開発
2020 - 2025 Elucidation of glycan function by synthetic glycans and glycan remodeling systems and their application to new immunotherapies
2020 - 2023 高次機能化リピドAの創製と自然-獲得免疫制御分子への展開
2020 - 2022 Elucidation of host-bacterial chemical ecology mediated by lipopolysaccharide and development of vaccine adjuvants
2020 - 2020 Functional analysis of glycans and immunoregulation by using synthetic glycans and glycan remodeling

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Papers (77)：

Al Arofatus Naini, Tri Mayanti, Erina Hilmayanti, Xuhao Huang, Kazuya Kabayama, Atsushi Shimoyama, Yoshiyuki Manabe, Koichi Fukase, Unang Supratman. Immunomodulatory of sesquiterpenoids and sesquiterpenoid dimers-based toll-like receptor 4 (TLR4) from Dysoxylum parasiticum stem bark. Scientific Reports. 2024. 14. 15597
Haruki Yamaura, Atsushi Shimoyama, Koji Hosomi, Kazuya Kabayama, Jun Kunisawa, Koichi Fukase. Chemical synthesis of Acetobacter pasteurianus lipid A with a unique tetrasaccharide backbone and evaluation of its immunological functions. Angewandte Chemie (International ed. in English). 2024. e202402922
Al Arofatus Naini, Tri Mayanti, Rani Maharani, Desi Harneti, Nurlelasari, Kindi Farabi, Sofa Fajriah, Erina Hilmayanti, Kazuya Kabayama, Atsushi Shimoyama, et al. Paraxylines A-G: Highly oxygenated preurianin-type limonoids with immunomodulatory TLR4 and cytotoxic activities from the stem bark of Dysoxylum parasiticum. Phytochemistry. 2024. 114009-114009
Koichi Fukase, Yoshiyuki Manabe, Atsushi Shimoyama. Diacetyl strategy for synthesis of NHAc containing glycans: enhancing glycosylation reactivity via diacetyl imide protection. Frontiers in Chemistry. 2023. 11
Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Azusa Saika, Haruki Yamaura, Takahiro Nagatake, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue. International Immunology. 2023

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MISC (41)：

島本博彰, 加藤弘樹, 片山大輔, 角永悠一郎, 大江一弘, HUANG Xuhao, 下山敦史, 下山敦史, 樺山一哉, 樺山一哉, et al. Intratumoral administration of astatine-211-labeled gold nanoparticles for alpha-particle therapy: Antitumor effect for a mouse model of tongue cancer. 歯科放射線. 2024. 64
兼田加珠子, 兼田加珠子, 王谷英達, 王谷英達, 王谷英達, 渡部直史, 渡部直史, 渡部直史, 真鍋良幸, 真鍋良幸, et al. Development of short-lived alpha-emitting nuclear medicine aiming at rare cancer treatment. 日本癌学会学術総会抄録集(Web). 2023. 82nd
井ノ口仁一, 狩野裕考, 新田昂大, 稲森啓一郎, 石川潮, 樺山一哉, 黄栩昊, 下山敦史, 深瀬浩一. GM3分子種によるTLR4及びCaspase4/11の活性化制御. 日本生化学会大会(Web). 2023. 96th
加藤弘樹, 角永悠一郎, 大江一弘, 黄栩昊, HILMAYANTI Erina, 下山敦史, 樺山一哉, 殷小杰, 羽場宏光, 豊嶋厚史, et al. 悪性腫瘍腹腔内播種治療のためのアスタチン標識金ナノ粒子の最適化. 核医学(Web). 2023. 60. Supplement
加藤弘樹, 片山大輔, 大江一弘, 角永悠一郎, 黄栩昊, 下山敦史, 樺山一哉, 深瀬浩一, 畑澤順. アスタチン標識金ナノ粒子の腹腔内投与における動態と生体への影響. 核医学(Web). 2022. 59. Supplement

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Patents (4)：

At-211アスタチン標識金ナノ粒子の局所投与による悪性腫瘍増殖抑制
金ナノ粒子含有医薬
Pharmaceutical composition containing 211AT-labeled amino acid derivative, and method for producing the pharmaceutical composition
Composition comprising light-emitting compound exhibiting afterglow and its application

Books (12)：

化学 2024年10月号
2024
エンドトキシン・自然免疫研究 25
2024
エンドトキシン・自然免疫研究 24
2024
生体分子と疾患 : ヘルスサイエンスの切り札としての化学
化学同人 2021 ISBN:9784759813999
フローマイクロ合成の最新動向
シーエムシー出版 2021 ISBN:9784781316154

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Education (3)：

- 2010 Osaka University
- 2007 Osaka University
- 2005 Osaka University School of Science Department of Chemistry

Professional career (2)：

Master of Science (Osaka University)
Doctor of Science (Osaka University)

Work history (8)：

2024 - 現在 JST創発的研究支援事業創発研究者
2024 - 現在 Osaka University Graduate School of Science Associate Professor
2014 - 2024 Osaka University Graduate School of Science assistant professor
2011 - 2014 Tokyo Institute of Technology Assistant Professor
2010 - 2011 Osaka University Graduate School of Science

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Committee career (8)：

2024 - 現在内毒素・LPS研究会運営委員
2017 - 現在 NapOsaka meeting organizing committee
2019 - 2022 16th Meeting of the International Endotoxin and Innate Immunity Society Secretariat
2019/05 - 2021/05 大阪大学理学部化学系教室同窓会永契会会計幹事
2018/04 - 2020/03 有機合成化学協会有機合成化学協会誌編集協力委員

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Awards (14)：

2023/12 - 第28回日本エンドトキシン・自然免疫研究会奨励賞・最優秀賞
2023/03 - 日本化学会第37回若い世代の特別講演証
2022/12 - Incentive Award in Synthetic Organic Chemistry, Japan
2022/11 - 令和4年度大阪大学賞若手教員部門
2021 - Japanese Society of Carbohydrate Research Incentive Award

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Association Membership(s) (10)：

有機合成化学協会 , 日本ケミカルバイオロジー学会 , 日本糖質学会 , 日本化学会 , Japanease society for chemical biology , The Japanese Society of Carbohydrate Research , The Chemical Society of Japan , 日本癌学会 , 近畿化学協会 , 日本エンドトキシン・自然免疫研究会

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