Rchr

J-GLOBAL ID：200901082086072305 Update date: Nov. 07, 2024

Anzai Naohiko

アンザイナオヒコ | Anzai Naohiko

Affiliation and department：
Job title： Professor and Chairman
Other affiliations (6)：

Dokkyo Medical University School of Medicine
Kyorin University Faculty of Medicine
University of Fukui
Shimane University Faculty of Medicine
Kanazawa Medical University

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Homepage URL (1)： http://www.m.chiba-u.ac.jp/class/pharmacology/pharmacology/Anzai.html

Research field (4)： Nephrology , Pharmacology , Clinical pharmacy , Physiology

Research keywords (17)：タンパク質間相互作用 , PDZタンパク質 , 生活習慣病 , メタボリック症候群 , 痛風・高尿酸血症 , 遺伝子疾患 , 創薬 , トランスポーター , 上皮輸送 , protein-protein interaction , PDZ proteins , hereditary tubular disorder , metabolic syndrome , hyperuricemia , gout , membrane transporter , Epithelial transport

Research theme for competitive and other funds (50)：

2023 - 2026 Evaluation of the Effect of Neutron Capture Therapy Using a Novel Gadolinium Preparation on Metastatic Bone Tumors
2023 - 2026 消化器官における糖代謝の調節因子としてみた1,5-AG機能の解明:加齢随伴性を念頭に
2022 - 2025 高齢時の体液貯留かつ低栄養を惹起する鍵分子はバソプレシンなのか?
2022 - 2025 脳虚血耐性におけるアストロサイト由来乳酸の役割の解明
2021 - 2024 Transporter-targeted drug development against urological cancers by utilizing liquid biopsy and AI

2021 - 2023 Development of new BNCT sensitizer based on molecular chirality recognition of amino acid transporter LAT

2020 - 2023 ながはまコホートおよび佐渡コホートのゲノム情報解析による、尿酸値関連変異の探索

2020 - 2023 Establishment of aminoacid transporter directed prostate cancer therapy based on the liquid biopsy

2020 - 2023 抗酸化作用を介した膵内外分泌から紐解く食品含有1,5-AGの生理機能

2019 - 2022 The study of pulmonary arterial hypertension with lung and bone marrow transplantation by GFP expressing rats

2019 - 2022 Elucidation of abnormal metabolic profile of endometrial cancer

2018 - 2021 Development of research on SLC transporters important for sperm function: Toward drug discovery and elucidation of the mechanism of fertility acquisition

2018 - 2021 New drug development targeting novel renal tubular rate transporter MCT9 based on the structure-activity relationship

2018 - 2021 Development of precision medicine for pancreatic cancer combining near infrared imaging and biological information

2017 - 2021 Development of a New Dual Excretion Iodine-Based X-ray Contrast Agent with Hepatocyte Contrast Function

2017 - 2020 Improvement of BNCT therapeutic gain based on selective protection of normal cells by LAT 2 inhibitor

2017 - 2020 Development of the new diagnostic method and drug discovery based on metabolic loam analysis of the castration-resistant prostate cancer

2017 - 2018 Development of specific inhibitor against tumor-type amino acid transporter LAT3 and analysis for its pathophysiological role

2014 - 2017 トランスポーター科学に基づくホウ素中性子捕捉療法BNCT用新規増感化合物開発

2014 - 2016 Development of a new Iodine contrast agent excreted into bile and urine based on the transporter selectivity

2013 - 2016 Analysis of disease-onset by identifying the transport substrate for Arterial Tortuosity Syndrome (ATS) disease gene GLUT10

2014 - 2016 Evaluation of 3-factor model (3F) of renal urate transport that may avoid less side-effect of druf-induced hyperuricemia.

2015 - 2015 非侵襲近赤外線計測による新規体内脂肪代謝リアルタイムモニタの開発

2012 - 2015 Role of LAT1 in T cell activation

2011 - 2015 Molecular target of urate-lowering drugs: Identification and functional characterization of a novel renal urate transporter URAT2

2011 - 2013 Novel regulatory mechanism of renaltubular transporter function by SUMOylation-deSUMOylation

2010 - 2012 Elucidation of drug transporting route - association between transporters and gap junction -

2009 - 2011 New drug development for hyperuricemia targeting novel urate efflux transporter URATv1

2009 - 2010 Changing of intracellular trafficking in polarized cells and regulation of serum urate level by the splicing variants of urate transporter URATv1.

2009 - 2010 ベンズブロマロン感受性を指標とした腎尿細管テトラヒドロビオプテリン輸送体の探索

2008 - 2010 Elucidation of mechanism for exercise-induced acute renal failure in urate transporter deficient mice

2005 - 2009 Organic solute transportsomes: their molecular assembly and functional significance

2006 - 2007 Role of a novel prostaglandin transporter OAT-PG in sodium transport regulation mechanism

2005 - 2006 Study on_the protein-protein interaction regulating the function of amino acid transporters

2004 - 2004 癌特異性アミノ酸トランスポーターLAT1発現を個性とする腫瘍の新規診断法の確立

2003 - 2004 Study of drug transport mechanism by renal organicion transporters and their clinical significance

2003 - 2004 Regulatory mechanism of urate transport function by urate transporter binding protein PDZK1

2002 - 2004 Development of novel anti-uricosuric agents based on the genomic strategy.

2001 - 2004 Genetic Abnormality of Renal Proximal Tubule-Specific Transporters as Causes of Sudden Death Syndrome in South-Eastern Asia

2003 - 2003 腫瘍関連抗原4F2重鎖(CD98)のmTORを介するシグナル機構の解明

2002 - 2003 Identification and functional characterization of all the genes of heterodimeric amino acid transporter family by means of whole genome information

2002 - 2002 がん特異中性アミノ酸トランスポーター(LAT1)の発現と制御機序

2000 - 2002 Identification of transporter genes regulating systemic kinetics of drugs and foreign compounds and their genetic polymorphism

2001 - Functional characterization of urate/organic anion/amino acid transporters

2001 - Identification of intracellular binding proteins for organic ion transporters

1999 - 2000 REGULATION OF BODY WATER AND ELECTROLYTES CONCENTRATIONS BY RENAL NA/K/2CL TRANSPORTER (NKCC2)

1998 - 1999 ラット腎髄質尿細管細胞における尿素輸送体の発現制御

1997 - 1998 EXPRESSION OF Na^+-DEPENDENT GLUCOSE TRANSPORTERS (SGLT1, SGLT2) IN RAT KIDNEY PROXIMAL TUBULES.

1997 - 1997 ATP感受性K+チャネル(Kir6.1)とNa+/K+ポンプの機能的連関

1996 - 1996 腎尿細管ATP感受性K^+チャネルのホンプ,輸送体との機能的連関

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Papers (224)：

Norie Hamaguchi-Suzuki, Naruhiko Adachi, Toshio Moriya, Satoshi Yasuda, Masato Kawasaki, Kano Suzuki, Satoshi Ogasawara, Naohiko Anzai, Toshiya Senda, Takeshi Murata. Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules. Biochemical and Biophysical Research Communications. 2024. 709. 149855-149855
Shinpei Saito, Keisuke Ando, Shinichi Sakamoto, Minhui Xu, Yasutaka Yamada, Junryo Rii, Sanji Kanaoka, Jiaxing Wei, Xue Zhao, Sangjon Pae, et al. The LAT1 inhibitor JPH203 suppresses the growth of castration-resistant prostate cancer through a CD24-mediated mechanism. Cancer science. 2024
Yuri Hirayama, Ha Pham Ngoc Le, Hirofumi Hashimoto, Itsuko Ishii, Schuichi Koizumi, Naohiko Anzai. Preconditioning-Induced Facilitation of Lactate Release from Astrocytes Is Essential for Brain Ischemic Tolerance. eNeuro. 2024. 11. 4
Shinichi Sakamoto, Keisuke Ando, Sangjon Pae, Xue Zhao, Kazuko Sakai, Kodai Sato, Shinpei Saito, Yasutaka Yamada, Junryo Rii, Yusuke Goto, et al. Copy Number Gain in Androgen Receptors Predicts the Poor Prognosis in Japanese Castration-resistant Prostate Cancer. Anticancer research. 2024. 44. 2. 639-647
Junryo Rii, Shinichi Sakamoto, Atsushi Mizokami, Minhui Xu, Ayumi Fujimoto, Shinpei Saito, Hidekazu Koike, Takaaki Tamura, Takayuki Arai, Yasutaka Yamada, et al. L-type amino acid transporter 1 inhibitor JPH203 prevents the growth of cabazitaxel-resistant prostate cancer by inhibiting cyclin-dependent kinase activity. Cancer science. 2024

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MISC (267)：

齋藤心平, 齋藤心平, 坂本信一, 安藤敬佑, 梨井隼菱, 山田康隆, 佐塚智和, 今村有佑, 金井好克, 安西尚彦, et al. 去勢抵抗性前立腺癌におけるアミノ酸トランスポーターLAT1選択的阻害薬JPH203を用いた抗腫瘍効果の検討. 泌尿器科分子・細胞研究会プログラム・抄録集. 2024. 33rd
裴祥存, 裴祥存, 坂本信一, 趙雪, 齋藤心平, 齋藤心平, 平山友里, 橋本弘史, 佐塚智和, 今村有佑, et al. Investigation of the role of 4F2hc in renal cell carcinoma. 日本泌尿器科学会総会(Web). 2023. 110th
安西尚彦, 森尾花恵, 霊園良恵, 北村里衣, 平山友里, 橋本弘史. プロテインキナーゼCによるヒトL型アミノ酸トランスポーター2輸送機能活性化. 日本腎臓学会誌. 2021. 63. 4. 448-448
林啓太朗, 神沼修, 西村友枝, 佐伯真弓, 岩田洋平, 杉浦一充, 遠藤仁, 藤田朋恵, 安西尚彦. LAT1阻害薬によるアトピー性皮膚炎の抑制. 臨床薬理. 2019. 50. Suppl. S355-S355
坂本信一, 今村有佑, 内垣洋祐, 稲田千秋, 池原譲, 安西尚彦, 赤倉功一郎, 市川智彦. 泌尿器科領域の遺伝カウンセリングとロールプレイの実際シスチン尿症における遺伝子診断の課題と展望. 日本泌尿器科学会総会. 2019. 107回. PDSES-3

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Patents (1)：

腎臓尿酸トランスポーター

Books (5)：

カッツング薬理学 : エッセンシャル
丸善出版 2021 ISBN:9784621306369
イラストレイテッド生理学
丸善出版 2021 ISBN:9784621306079
エース薬理学
南山堂 2020 ISBN:9784525140717
コメディカルのための薬理学
朝倉書店 2018 ISBN:9784254330106
実践臨床薬理学
朝倉書店 2010 ISBN:9784254310924

Education (1)：

- 1990 Chiba University School of Medicine

Professional career (1)：

Ph.D. (Chiba University)

Work history (8)：

2016/01 - 現在 Chiba University Graduate School of Medicine Department of Pharmacology Professor and chairman
2011/04 - 2015/12 Dokkyo Medical University Department of Pharmacology and Toxicology, School of Medicine Professor and chairman
2008/10 - 2011/03 Kyorin University School of Medicine Department of Pharmacology and Toxicology Associate Professor
2006 - 2008 Kyorin University Faculty of Medicine
2004 - 2006 Kyorin University Faculty of Medicine

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Committee career (14)：

2023/07 - 現在日仏医学会会長
- 現在日本がん分子標的治療学会評議員
- 現在日本尿路結石症学会評議員
- 現在日本高血圧学会評議員
- 現在日本臨床薬理学会評議員、国際交流・リエゾン委員

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Awards (12)：

2012/12 - 日本痛風・核酸代謝学会平成24年度痛風と核酸代謝誌優秀論文賞
2012/02 - 日本痛風・核酸代謝学会第13回学会賞受賞
2011/12 - 獨協医科大学第12回関湊賞(研究助成)受賞
2011/11 - 日本動物実験代替法学会 2011リファインメント賞
2011/06 - 第54回日本腎臓学会学術年会優秀発表賞

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Association Membership(s) (18)：

日仏医学会 , 日本尿路結石症学会 , THE JAPANESE SOCIETY OF TOXICOLOGY , THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER , アメリカ生理学会(APS) , アメリカ腎臓学会(ASN) , THE JAPANESE SOCIETY OF HYPERTENSION , 日本臨床薬理学会 , 日本癌学会 , 日本内分泌学会 , 日本消化吸収学会 , 日本痛風核酸代謝学会 , 日本腎臓学会 , 日本生理学会 , 日本薬理学会 , トランスポーター研究会 , American Physiological Society , American Society of Nephrology

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